ChemicalBook > CAS DataBase List > 2,5-Dibromopyridine

2,5-Dibromopyridine

Product Name
2,5-Dibromopyridine
CAS No.
624-28-2
Chemical Name
2,5-Dibromopyridine
Synonyms
Dibromopyridine;NSC 76597;5-DibroMopyridine;2,5-Dibrompyridin;2,5-dibromopyridin;2,5 dibromopyrdine;2,5-DIBROMOPYRIDINE;3,6-DibroMopyridine;2,5 Di bromo pyridne;Perampanel Impurity 9
CBNumber
CB7283491
Molecular Formula
C5H3Br2N
Formula Weight
236.89
MOL File
624-28-2.mol
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2,5-Dibromopyridine Property

Melting point:
92-95 °C (lit.)
Boiling point:
235 °C / 772mmHg
Density 
2.0383 (rough estimate)
refractive index 
1.5800 (estimate)
Flash point:
62℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
-1.57±0.10(Predicted)
form 
Crystalline Powder
color 
Almost white or light beige to brown
Water Solubility 
insoluble
BRN 
109099
InChI
InChI=1S/C5H3Br2N/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey
ZHXUWDPHUQHFOV-UHFFFAOYSA-N
SMILES
C1(Br)=NC=C(Br)C=C1
CAS DataBase Reference
624-28-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-37/39-36/37/39-36
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D43107
Product name
2,5-Dibromopyridine
Purity
98%
Packaging
10g
Price
$96.9
Updated
2024/03/01
TCI Chemical
Product number
D1217
Product name
2,5-Dibromopyridine
Purity
>99.0%(GC)
Packaging
5g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
D1217
Product name
2,5-Dibromopyridine
Purity
>99.0%(GC)
Packaging
25g
Price
$66
Updated
2024/03/01
Alfa Aesar
Product number
A10937
Product name
2,5-Dibromopyridine, 97%
Packaging
10g
Price
$70.65
Updated
2024/03/01
Alfa Aesar
Product number
A10937
Product name
2,5-Dibromopyridine, 97%
Packaging
50g
Price
$257.65
Updated
2024/03/01
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2,5-Dibromopyridine Chemical Properties,Usage,Production

Description

Pyridine and its derivatives are distributed widely by nature. Many plant constituents are as contain pyridine ring compounds in the structure of alkaloids, etc.; they are the bases producing many vital compounds and are indispensable raw materials during medicine, agricultural chemicals, dyestuff, tension-active agents, rubber ingredients, fodder additives, foodstuff additives, tackiness agents, etc. are produced.2,5-dibromo pyridine is an important intermediate of organic synthesis and is mainly used in medicine intermediate, organic synthesis, and organic solvent, can also be applicable to aspects such as DYE PRODUCTION, pesticide production and spices. Selective monolithiation of 2,5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence the selectivity. Coordinating solvents and higher concentration favour the 5-position, while non-coordinating solvents and lower concentration favour the 2-position[1].

Chemical Properties

2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.

Uses

2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis.

Preparation

To synthesize 2,5-dibromopyridine, follow these steps:
Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C.
Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture.
Introduce liquid bromine (11 L) into the mixture.
Maintain the reaction temperature below 10 °C.
Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C.
Stir the reaction mixture for 30 minutes.
Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C.
Extract the reaction mixture with diethyl ether (3 × 40 L).
Dry the organic layer with anhydrous Na2SO4.
Remove the desiccant by filtration.
Evaporate the resulting filtrate under reduced pressure to dryness.
Suspend the residue in heptane (10 L).
Collect the target product molecule, 2,5-dibromopyridine, by filtration.
Synthesis method of 2,5-dibromopyridine

References

[1] Xin Wang. “Selective monolithiation of 2,5-dibromopyridine with butyllithium.” Tetrahedron Letters 41 1 (2000): 4335–4338.

2,5-Dibromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Bromo-5-iodopyridine 5-Bromo-2-pyridinecarboxylic Acid 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE 6-Methoxynicotinaldehyde 2-(5-BROMO-2-PYRIDYLAZO)-5-(DIETHYLAMINO)PHENOL 2-Bromopyridine-5-boronic acid 5-(Trifluoromethyl)pyridine-2-carboxylic acid 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIDINE 6-(1-PYRROLIDINYL)NICOTINALDEHYDE 5-Bromo-3-pyridinecarboxaldehyde 2-Trifluoromethyl-5-bromopyridine
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View Lastest Price from 2,5-Dibromopyridine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
2,5-Dibromopyridine 624-28-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-12
Watson Biotechnology Co.,Ltd
Product
2,5-Dibromopyridine 624-28-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-08-02
Shanghai UCHEM Inc.
Product
2,5-Dibromopyridine 624-28-2
Price
US $136.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100kg
Release date
2023-11-17

624-28-2, 2,5-DibromopyridineRelated Search:

3,5-DIBROMOPYRIDINE 1,2-DIBROMOETHYLENE 1,3-Bis(bromomethyl)benzene 2,2-Bis(bromomethyl)propane-1,3-diol DBDCB 1,3-Dibromo-5,5-dimethylhydantoin meso-2,3-Dibromosuccinic acid 2,4-DIBROMOPENTANE 2-Chloro-3-cyanopyridine 1,2-Dibromopropane 2-PHENYL-1,3,2-DIOXABORINANE PeraMpanel PeraMpanel 6'-Methoxy-2,3'-bipyridine PeraMpanel PeraMpanel PeraMpanel 2-Cyanophenylboronic acid

  • 2,5-DIBROMOPYRIDINE
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  • 2,5-Dibromopyridine, 97+%
  • 2,5-dibromopyridin
  • 2,5-DIBROMOPYRIDINE 2,5-DIBROMOPYRIDINE
  • 2,5-Dibromo pyridine ,98%
  • 2,5-DibroMopyridine, 97% 10GR
  • 3,6-DibroMopyridine
  • NSC 76597
  • 5-DibroMopyridine
  • 2, 5-2 broMide pyridine
  • 2,5 Di bromo pyridne
  • 2,5-Dibromopyridine &gt
  • Perampanel Impurity 9
  • 2,5-Dibromopyridine ISO 9001：2015 REACH
  • 2,5-Dibrompyridin
  • 2,5 dibromopyrdine
  • Hot Sale?2, 5-Dibromopyridine CAS?624-28-2?with Best Price
  • Pyronoprene Impurity 17
  • Nicotinic Acid Impurity 13
  • 624-28-2
  • 324-28-2
  • Building Blocks
  • Pyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Bromopyridines
  • Halopyridines
  • alkyl bromide
  • Building Blocks
  • C5
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Brominated heterocyclic series
  • Aromatics
  • Bases & Related Reagents
  • Nucleotides
  • Aromatics Compounds
  • Bromopyridines
  • Halopyridines
  • Pyridine series
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Nitrogen cyclic compounds
  • blocks
  • Bromides
  • Pyridines
  • pyridine derivative
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Pyridine
  • Pyridines derivates
  • bc0001
  • 624-28-2