ChemicalBook > CAS DataBase List > Propargyl-PEG5-t-butyl ester

Propargyl-PEG5-t-butyl ester

Product Name
Propargyl-PEG5-t-butyl ester
CAS No.
1245823-50-0
Chemical Name
Propargyl-PEG5-t-butyl ester
Synonyms
Propargyl-PEG5-COOtBu;PropargylPEG5-tBu ester;Propargyl-PEG4-C2-COOtBu;Alkyne-PEG5-CH2CH2COOtBu;Propargyl-PEG4-CH2CH2-Boc;PROPARGYL-PEG5-CH2CH2COOTBU;Propargyl-PEG5-t-butyl ester;1-Boc-3,6,9,12,15-pentaoxaoctadec-17-yne;tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate;4,7,10,13,16-Pentaoxanonadec-18-ynoic acid, 1,1-dimethylethyl ester
CBNumber
CB73048734
Molecular Formula
C18H32O7
Formula Weight
360.44
MOL File
1245823-50-0.mol
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Propargyl-PEG5-t-butyl ester Property

Boiling point:
420.6±40.0 °C(Predicted)
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
P839468
Product name
Propargyl-PEG5-t-butylEster
Packaging
100mg
Price
$330
Updated
2021/12/16
Apolloscientific
Product number
BIPG1746
Product name
Propargyl-PEG5-t-butylester
Packaging
250mg
Price
$482
Updated
2021/12/16
BroadPharm
Product number
BP-20651
Product name
Propargyl-PEG5-t-butylester
Purity
98%
Packaging
250mg
Price
$230
Updated
2021/12/16
Activate Scientific
Product number
AS107878
Product name
Propargyl-PEG5-CH2CH2COOtBu
Purity
97%
Packaging
250mg
Price
$310
Updated
2021/12/16
Acrotein
Product number
B-1477
Product name
Propargyl-PEG4-CH2CH2COOtBu
Purity
97%
Packaging
0.5g
Price
$256.67
Updated
2021/12/16
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Propargyl-PEG5-t-butyl ester Chemical Properties,Usage,Production

Description

Propargyl-PEG5-t-butyl ester has one of the functional groups protected by t-butyl group. The protection can be removed under acidic conditions. The propargyl group forms triazole linkages with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The PEG units help improving the water-solubility of the molecule in aqueous media.

Uses

Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2CH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Non-cleavable Linker; Alkyl/ether

References

[1] Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275. DOI:10.1021/acs.bioconjchem.8b00047

Propargyl-PEG5-t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Propargyl-PEG5-t-butyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG5-COOtBu 1245823-50-0
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-26

1245823-50-0, Propargyl-PEG5-t-butyl esterRelated Search:


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