ChemicalBook > CAS DataBase List > Danirixin

Danirixin

Product Name
Danirixin
CAS No.
954126-98-8
Chemical Name
Danirixin
Synonyms
CS-1940;CS-2750;Danirixin;GSK1325756;Danirixin HCl;Danirixin (GSK1325756);Solabegron Hydrochloride;Danirixin, 10 mM in DMSO;Danirixin (GSK1325756) ，S6620;CXCR,GSK 1325756,Inhibitor,inhibit,Danirixin,CXC chemokine receptors,GSK-1325756
CBNumber
CB73121091
Molecular Formula
C19H21ClFN3O4S
Formula Weight
441.9
MOL File
954126-98-8.mol
More
Less

Danirixin Property

Melting point:
>153°C (dec.)
Boiling point:
533.1±50.0 °C(Predicted)
Density 
1.467±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Methanol (Slightly)
pka
4.95±0.10(Predicted)
form 
Solid
color 
White to Light Brown
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3839
Product name
Danirixin
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$145.35
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3839
Product name
Danirixin
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$616
Updated
2025/07/31
Cayman Chemical
Product number
20980
Product name
Danirixin
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
20980
Product name
Danirixin
Purity
≥98%
Packaging
5mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
20980
Product name
Danirixin
Purity
≥98%
Packaging
10mg
Price
$274
Updated
2024/03/01
More
Less

Danirixin Chemical Properties,Usage,Production

Uses

Antidiabetic (β3 adrenoreceptor agonist).

Biological Activity

Danirixin (GSK1325756) is an orally active, selective CXC chemokine receptor 2 (CXCR2) antagonist with 78-fold lower affinity toward CXCR1 (CXCR2/CXCR1 IC50 = 12.5/977 nM by competitive binding against 0.225 nM [125I] CXCL8). Danirixin blocks agonist-induced neutrophil CD11b expression in vitro (IC50 = 420/890 nM against induction by 10 nM human CXCL1/r at CXCL2 using rat/human whole blood) and prevents lung neutrophils influx in rats in vivo following aerosol lipopolysaccharide or ozone challenge (ED50 = 1.4 and 16 mg/kg, respectively).

IC 50

CXCL8-CXCR2: 12.5 nM (IC50)

Danirixin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Danirixin Suppliers

China 69 United States 9 Global 78
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
More
Less

View Lastest Price from Danirixin manufacturers

Career Henan Chemical Co
Product
Danirixin 954126-98-8
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

954126-98-8, DanirixinRelated Search:

daprodustat N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2126458 ABT 702 Dihydrochloride GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

  • Danirixin
  • GSK1325756
  • Danirixin (GSK1325756)
  • Solabegron Hydrochloride
  • Danirixin HCl
  • 1-[4-Chloro-2-hydroxy-3-(piperidine-3-sulfonyl)-phenyl]-3-(3-fluoro-2-methyl-phenyl)-urea
  • CS-2750
  • CS-1940
  • N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea
  • Urea, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-
  • CXCR,GSK 1325756,Inhibitor,inhibit,Danirixin,CXC chemokine receptors,GSK-1325756
  • Danirixin, 10 mM in DMSO
  • Danirixin (GSK1325756) ，S6620
  • (s)-1-(4-chloro-2-hydroxy-3-(piperidin-3-ylsulfonyl)phenyl)-3-(3-fluoro-2-methylphenyl)urea hydrochloride
  • 954126-98-8