ChemicalBook > CAS DataBase List > 2'-BROMO-5'-FLUOROACETOPHENONE

2'-BROMO-5'-FLUOROACETOPHENONE

Product Name: 2'-BROMO-5'-FLUOROACETOPHENONE
CAS No.: 1006-33-3
Chemical Name: 2'-BROMO-5'-FLUOROACETOPHENONE
Synonyms: 2'-Bromo-5'-fluoroacetophenone;2'-Bromo-5'-fluoroacetophenone;13C7]-2',4'-Dichloroacetophenone;Acetophenone, 2'-bromo-5'-fluoro-;2'-Bromo-5'-fluoroacetophenone,98%;1-(2-bromo-5-fluorophenyl)ethanone;2'-Bromo-5'-fluoroacetophenone, 99%;Ethanone,1-(2-bromo-5-fluorophenyl)-;1-(2-Bromo-5-fluorophenyl)ethan-1-one;"2-Bromo-5-fluoroacetophenone 13C2, D3"
CBNumber: CB7318797
Molecular Formula: C8H6BrFO
Formula Weight: 217.04
MOL File: 1006-33-3.mol

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2'-BROMO-5'-FLUOROACETOPHENONE Property

Boiling point:: 144℃/18mm
Density: 1.535±0.06 g/cm3(Predicted)
refractive index: 1.5525
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in methanol.
form: liquid
color: Clear, pale lemon/lime

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Safety

HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B684870
Product name: 2''-Bromo-5''-fluoroacetophenone
Packaging: 25g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB44577
Product name: 2'-Bromo-5'-fluoroacetophenone
Packaging: 2g
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2617-B-37
Product name: 2'-Bromo-5'-fluoroacetophenone
Packaging: 5G
Price: $199
Updated: 2021/12/16

Apolloscientific

Product number: PC32800
Product name: 2'-Bromo-5'-fluoroacetophenone
Packaging: 10g
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB44577
Product name: 2'-Bromo-5'-fluoroacetophenone
Packaging: 10g
Price: $165
Updated: 2021/12/16

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2'-BROMO-5'-FLUOROACETOPHENONE Chemical Properties,Usage,Production

Uses

2'-Bromo-5'-fluoroacetophenone is used in the synthesis of oxabicyclic compounds. It is also used in the enantioselective synthesis of chiral 3-aryl-1-indanone molecules.

Synthesis

906673-56-1

1006-33-3

General procedure for the synthesis of 2-bromo-5-fluoroacetophenone from 1-(2-bromo-5-fluorophenyl)ethanol: 1. Preparation of 1-(2-bromo-5-fluorophenyl)ethanone Trichloroisocyanuric acid (59.5 g, 0.256 mol, 1.05 eq.) was added to a solution of 1-(2-bromo-5-fluorophenyl)ethanol (53.4 g, 0.2438 mol) in dichloromethane (500 mL) at 0-20 °C. To the resulting suspension was added TEMPO (2,2,6,6-tetramethylpiperidine 1-yloxy; 188 mg, 1.20 mmol, 0.5 mol%). The reaction mixture was stirred at ice bath temperature until the oxidation was complete (HPLC monitoring, about 4.5 hours). The reaction mixture was diluted with methyl tert-butyl ether (MTBE, ca. 1300 mL), sequentially with 1N NaOH (2 × 250 mL), 1N HCl containing potassium iodide (for the removal of TEMPO; 8 g of KI in 1000 mL of 1N HCl; 2 × 250 mL), 1N NaHCO3 containing sodium thiosulfate (for the removal of I2; 15 g Na2S2O3 in 1000 mL of 1N NaHCO3), 1N HCl containing potassium iodide (1 × 200 mL), 1N NaHCO3 containing sodium thiosulfate (2 × 200 mL), and brine (150 mL) washed. After drying (anhydrous MgSO4), the solvent was removed under reduced pressure to give 1-(2-bromo-5-fluorophenyl)ethanone as a light amber liquid (52.96 g, about 97% yield) with 98% purity by HPLC, which can be used in the next reaction without further purification. 1H-NMR (300MHz, CDCl3) δ 7.59 (dd, J=8.7,4.9Hz, 1H), 7.19 (dd, J=8.5,3.0Hz, 1H), 7.04 (ddd, J=9.1,7.8,3.0Hz, 1H), 2.64 (s, 3H).

References

[1] Patent: WO2010/111418, 2010, A2. Location in patent: Page/Page column 99
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 22, p. 7836 - 7848
[3] Journal of Organic Chemistry, 2017, vol. 82, # 21, p. 11585 - 11593
[4] Organic Letters, 2012, vol. 14, # 12, p. 3230 - 3232
[5] Journal of the American Chemical Society, 2014, vol. 136, # 48, p. 16748 - 16751

2'-BROMO-5'-FLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2'-BROMO-5'-FLUOROACETOPHENONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2'-BROMO-5'-FLUOROACETOPHENONE 1006-33-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-07-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2"-BROMO-5"-FLUOROACETOPHENONE 1006-33-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2"-BROMO-5"-FLUOROACETOPHENONE 1006-33-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1006-33-3, 2'-BROMO-5'-FLUOROACETOPHENONERelated Search:

3'-Bromo-4'-fluoroacetophenone97%,3'-BROMO-4'-FLUOROACETOPHENONE,3-BROMO-4-FLUOROACETOPHENONE,3- BROMO-4-FLUOROACETOPHENONE 98+% 2-Bromo-2',4'-difluoroacetophenone 4'-BROMO-3'-NITROACETOPHENONE 3,5-DIFLUOROPHENACYL BROMIDE 4'-Fluoro-3'-nitroacetophenone 3'-Bromo-2'-Fluoroacetophenone 2'-Bromo-4'-fluoroacetophenone97%,2'-Bromo-4'-fluoroacetophenone 97% 2-Bromo-4'-fluoroacetophenone 2-BROMO-2'-FLUOROACETOPHENONE 2-BROMO-3'-FLUOROACETOPHENONE,ALPHA-BROMO-3-FLUOROACETOPHENONE ALPHA,ALPHA-DIBROMO-4-FLUOROACETOPHENONE 1-(4-Bromo-2-fluorophenyl)ethanone 2'-BROMO-5'-FLUOROACETOPHENONE 2-Bromo-5-fluorobenzaldehyde 3-(2'-BROMO-5'-FLUOROPHENYL)-3-OXOPROPANENITRILE

1-(2-bromo-5-fluorophenyl)ethanone

1-(2-Bromo-5-fluorophenyl)ethan-1-one

Ethanone,1-(2-bromo-5-fluorophenyl)-

Acetophenone, 2'-bromo-5'-fluoro-

2'-Bromo-5'-fluoroacetophenone,98%

"2-Bromo-5-fluoroacetophenone 13C2, D3"

2'-Bromo-5'-fluoroacetophenone

13C7]-2',4'-Dichloroacetophenone

2'-Bromo-5'-fluoroacetophenone, 99%

2'-Bromo-5'-fluoroacetophenone

1006-33-3

Adehydes, Acetals & Ketones

Bromine Compounds

Fluorine Compounds