2-Bromo-4'-fluoroacetophenone
- Product Name
- 2-Bromo-4'-fluoroacetophenone
- CAS No.
- 403-29-2
- Chemical Name
- 2-Bromo-4'-fluoroacetophenone
- Synonyms
- 2-bromo-1-(4-fluorophenyl)ethan-1-one;4-FLUOROPHENACYL BROMIDE;2-BROMO-1-(4-FLUOROPHENYL)ETHANONE;2-Bromo-4'-fL;Vonoprazan-032;AKOS BBS-00003857;BUTTPARK 41\03-58;TIMTEC-BB SBB006561;TAK438 Impurity 101;TAK438 Impurity 102
- CBNumber
- CB7169175
- Molecular Formula
- C8H6BrFO
- Formula Weight
- 217.04
- MOL File
- 403-29-2.mol
2-Bromo-4'-fluoroacetophenone Property
- Melting point:
- 47-49 °C(lit.)
- Boiling point:
- 150 °C12 mm Hg(lit.)
- Density
- 1.5728 (rough estimate)
- refractive index
- 1.5450 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in methanol.
- form
- Powder
- color
- White to brownish-yellow to light grey
- Sensitive
- Lachrymatory
- BRN
- 637863
- CAS DataBase Reference
- 403-29-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetophenone, 2-bromo-4'-fluoro-(403-29-2)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive/Lachrymatory/Keep Cold
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 389390
- Product name
- 2-Bromo-4′-fluoroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $31.4
- Updated
- 2025/07/31
- Product number
- 389390
- Product name
- 2-Bromo-4′-fluoroacetophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $96.6
- Updated
- 2025/07/31
- Product number
- B2382
- Product name
- 2-Bromo-4'-fluoroacetophenone
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- B2382
- Product name
- 2-Bromo-4'-fluoroacetophenone
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- B684615
- Product name
- 2-Bromo-4’-fluoroacetophenone
- Packaging
- 25g
- Price
- $210
- Updated
- 2021/12/16
2-Bromo-4'-fluoroacetophenone Chemical Properties,Usage,Production
Chemical Properties
beige to light grey-green cryst. powder or flakes
Uses
2-Bromo-4'-fluoroacetophenone is used as an organic chemical synthesis intermediate.
Uses
2-Bromo-4’fluoroacetophenone is a intermediate in the synthetic preparation of competitive inhibitors of aromatase.
Synthesis
403-42-9
403-29-2
General procedure for the synthesis of 2-bromo-4'-fluoroacetophenone using 4-fluoroacetophenone as starting material: general method: oxone (1.352 g, 2.2 mmol) was added to a well-stirred methanol (10 ml) solution of 4-fluoroacetophenone (2 mmol) and NH4Br (0.215 g, 2.2 mmol), and the reaction mixture was stirred at room temperature (or refluxed at temperature reaction). The reaction progress was monitored by TLC. Upon completion of the reaction, the reaction mixture was quenched with aqueous sodium thiosulfate, followed by extraction with ethyl acetate (3 x 25 ml). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to remove the solvent to give the crude product. The crude product was further purified by silica gel column chromatography (200-300 mesh) to give pure 2-bromo-4'-fluoroacetophenone. All products were structurally confirmed by 1H NMR and mass spectrometry data.
References
[1] Farmaco, 1993, vol. 48, # 6, p. 857 - 869
[2] Synthesis, 2008, # 2, p. 253 - 266
[3] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[4] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[5] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 6, p. 1327 - 1334
2-Bromo-4'-fluoroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4'-fluoroacetophenone Suppliers
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View Lastest Price from 2-Bromo-4'-fluoroacetophenone manufacturers
- Product
- p-Fluorophenacyl bromide 403-29-2
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Bromo-4'-fluoroacetophenone 403-29-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20