2-Bromo-2'-fluoroacetophenone

Product Name: 2-Bromo-2'-fluoroacetophenone
CAS No.: 655-15-2
Chemical Name: 2-Bromo-2'-fluoroacetophenone
Synonyms: ω-BroMo-2;Vonoprazan-030;BUTTPARK 35\01-51;TAK438 Impurity 83;Vonoprazan Impurity 83;2-FLUOROPHENACYL BROMIDE;o-Fluorophenacyl BroMide;2-Fluorophenacylbromide98%;Vonolazan fumarate impurity;α-BroMo-2-fluoroacetophenone
CBNumber: CB8182528
Molecular Formula: C8H6BrFO
Formula Weight: 217.04
MOL File: 655-15-2.mol

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2-Bromo-2'-fluoroacetophenone Property

Melting point:: 25-27
Boiling point:: 83-85
Density: 1.574 g/mL at 25 °C
refractive index: n20/D1.563
Flash point:: >110 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Sensitive: Lachrymatory
Stability:: Unstable in DMSO
CAS DataBase Reference: 655-15-2(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 36/37/38-34
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3261 8 / PGIII
WGK Germany: 3
Hazard Note: Corrosive/Lachrymatory/Keep Cold
HazardClass: LACHRYMATOR, CORROSIVE
HazardClass: 8
PackingGroup: III
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 759384
Product name: 2-Bromo-2′-fluoroacetophenone
Purity: 97%
Packaging: 5g
Price: $69.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 759384
Product name: 2-Bromo-2′-fluoroacetophenone
Purity: 97%
Packaging: 25g
Price: $162.45
Updated: 2025/07/31

TCI Chemical

Product number: B5104
Product name: 2-Bromo-2'-fluoroacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $123
Updated: 2025/07/31

TCI Chemical

Product number: B5104
Product name: 2-Bromo-2'-fluoroacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $492
Updated: 2025/07/31

TRC

Product number: B684355
Product name: 2-Bromo-2’-fluoroacetophenone
Packaging: 25g
Price: $205
Updated: 2021/12/16

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2-Bromo-2'-fluoroacetophenone Chemical Properties,Usage,Production

Chemical Properties

Liquid

Uses

A new class of acetophenone-based cinchona alkaloid-derived quaternary ammonium salts were prepared and evaluated as phase-transfer catalysts in the enantioselective alkylation of glycine imine ester.

Synthesis

445-27-2

655-15-2

General procedure for the synthesis of 2-bromo-2'-fluoroacetophenone from o-fluoroacetophenone: bromine (5.8 mL) was added slowly and dropwise to a solution of 1-(2-fluorophenyl)ethanone (15.1 g) in acetic acid (150 mL). The reaction mixture was stirred at room temperature for 2 h. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate, water and saturated brine and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford 2-bromo-2'-fluoroacetophenone (22.91 g, 97% yield) as a light yellow oil. The product was characterized by 1H-NMR (CDCl3): δ 4.53 (2H, d, J = 2.4 Hz), 7.13-7.20 (1H, m), 7.27-7.30 (1H, m), 7.54-7.61 (1H, m), 7.91-7.96 (1H, m).

References

[1] Patent: US2009/156642, 2009, A1. Location in patent: Page/Page column 40
[2] Patent: EP2196459, 2010, A1. Location in patent: Page/Page column 78
[3] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 20, p. 3763 - 3772
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582

2-Bromo-2'-fluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

3-(2-FLUORO-PHENYL)-ISOXAZOL-5-YLAMINE

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2-Bromo-2'-fluoroacetophenone Suppliers

Americas 1 Austria 1 Canada 1 China 201 Europe 3 France 1 Germany 2 India 7 Italy 1 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 11 United States 21 Global 253

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Alfa Aesar

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Energy Chemical

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Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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View Lastest Price from 2-Bromo-2'-fluoroacetophenone manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-2'-fluoroacetophenone 655-15-2
Price: US $8.00-3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

Honest Joy Holdings Limited

Product: 2-Bromo-1-(2-fluorophenyl)ethanone 655-15-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: 2-Bromo-2'-fluoroacetophenone 655-15-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 515
Release date: 2019-09-01

655-15-2, 2-Bromo-2'-fluoroacetophenoneRelated Search:

3-Nitroacetophenone Calcium bromide Ethidium bromide 4'-(Trifluoromethyl)acetophenone 4-Nitroacetophenone 1-(2,6-Difluorophenyl)ethan-1-one 2',4'-Difluoroacetophenone Trifluoroacetophenone Acetophenone 2',4'-Dichloroacetophenone 2-Fluorobenzyl cyanide 2'-Fluoroacetophenone Sodium bromate 4-Fluoroacetophenone 3'-Fluoroacetophenone 2-Bromoacetophenone 2-Bromo-2'-nitroacetophenone 4'-Bromoacetophenone

BUTTPARK 35\01-51

2-BROMO-2'-DIFLUOROACETOPHENONE

Ethanone, 2-bromo-1-(2-fluorophenyl)- (9CI)

2-Fluorophenacylbromide98%

2-FLUOROPHENACYL BROMIDE

2-Bromo-1-(2-fluoro-phenyl)-ethanone

2-Fluorophenacyl bromide&nbsp

Vonoprazan Fumarate Impurity 88

TAK438 Impurity 83

2-Bromo-2'-fluoroacetophenone, 2-Bromo-1-(2-fluorophenyl)ethan-1-one

1-BroMo-2'-fluoroacetophenone

o-Fluorophenacyl BroMide

α-BroMo-2-fluoroacetophenone

ω-BroMo-2

Ethanone,2-bromo-1-(2-fluorophenyl)-

2-Bromo-2'-fluoroacetophentone

2-Bromo-2'-Fluoroacetophenone,>98%

Vonolazan fumarate impurity

Vonoprazan-030

Vonoprazan Impurity 83

2-Bromo-2'-fluoroacetophenone ISO 9001：2015 REACH

2-bromo-1-(2-fluorophenyl)ethan-1-one

2-Bromo-2'-fluoroacetophenone

2-BROMO-2'-FLUOROACETOPHENONE 98%

2-Bromo-2'-fluoroacetophenone

655-15-2

Aromatics

ACETYLHALIDE

Ketone