4'-Fluoro-3'-nitroacetophenone
- Product Name
- 4'-Fluoro-3'-nitroacetophenone
- CAS No.
- 400-93-1
- Chemical Name
- 4'-Fluoro-3'-nitroacetophenone
- Synonyms
- 4′-Fluor-3′-nitroacetophenon;4-Fluoro-3-nitroacetophneone;4-FLUORO-3-NITROACETOPHENONE;4-FLUORO-3'-NITROACETOPHENONE;4'-Fuoro-3'-nitroacetophenone;4'-Fluoro-3'-notroacetophenone;4'-Fluoro-3'-nitroacetophenone;4'-Fluoro-3'-nitroacetophenone>4'-Fluoro-3'-nitroacetophenone,98%;1-(4-FLUORO-3-NITRO-PHENYL)-ETHANONE
- CBNumber
- CB0154158
- Molecular Formula
- C8H6FNO3
- Formula Weight
- 183.14
- MOL File
- 400-93-1.mol
4'-Fluoro-3'-nitroacetophenone Property
- Melting point:
- 47-51 °C
- Boiling point:
- 118-120°C 0,8mm
- Density
- 1.336±0.06 g/cm3(Predicted)
- Flash point:
- 118-120°C/0.8mm
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- color
- Light yellow
- BRN
- 2211976
- InChIKey
- PTCNZDJJIOLIKQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 400-93-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 676357
- Product name
- 4′-Fluoro-3′-nitroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $44.8
- Updated
- 2023/01/07
- Product number
- 676357
- Product name
- 4′-Fluoro-3′-nitroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $204
- Updated
- 2023/01/07
- Product number
- F0777
- Product name
- 4'-Fluoro-3'-nitroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- F0777
- Product name
- 4'-Fluoro-3'-nitroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $276
- Updated
- 2025/07/31
- Product number
- F489640
- Product name
- 4''-Fluoro-3''-nitroacetophenone
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
4'-Fluoro-3'-nitroacetophenone Chemical Properties,Usage,Production
Chemical Properties
light yellow crystalline powder
Uses
4''-?Fluoro-?3''-?nitroacetophenone is used as reactant/reagent in preparation of substituted furans via copper-catalyzed radical addition of acetophenones to alkynes.
Synthesis
403-42-9
400-93-1
General procedure for the synthesis of 4-fluoro-3-nitroacetophenone from 4-fluoroacetophenone: 1-(4-fluorophenyl)ethanone (1.10 g, 7.97 mmol) was dissolved in concentrated H2SO4 (5 mL) under stirring conditions. Subsequently, a mixed acid consisting of concentrated HCl and concentrated H2SO4 (2 mL) was slowly added. HNO3 (1.50 mL) was added slowly and dropwise at -15°C. The reaction mixture was continued to be stirred at -15 °C for 80 min, after which it was poured into ice-cold H2O (120 mL) and extracted with EtOAc (2 × 100 mL). The organic layers were combined and washed sequentially with H2O (100 mL) and brine (100 mL), and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 100-200 mesh, 40% EtOAc in hexane solution) to afford 4-fluoro-3-nitroacetophenone (0.80 g, 55%) as an off-white solid.1H NMR (400 MHz, CDCl3) δ 2.64 (s, 3H), 7.39 (t, J=9.30 Hz, 1H), 8.20- 8.26 (m, 1H), 8.57-8.66 (m, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1725 - 1728
[2] Patent: WO2017/89453, 2017, A1. Location in patent: Page/Page column 55
[3] Patent: WO2007/103260, 2007, A1. Location in patent: Page/Page column 63-64
[4] Archiv der Pharmazie (Weinheim, Germany), 1957, vol. 290, p. 587,595
[5] Archiv der Pharmazie, 1963, vol. 296, p. 324 - 336
4'-Fluoro-3'-nitroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-Fluoro-3'-nitroacetophenone manufacturers
- Product
- 4'-Fluoro-3'-nitroacetophenone 400-93-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2025-08-14
- Product
- 4'-Fluoro-3'-nitroacetophenone 400-93-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2025-03-14
- Product
- 4'-Fluoro-3'-nitroacetophenone 400-93-1
- Price
- US $1.00-12.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2024-07-26