ChemicalBook > CAS DataBase List > 4'-Fluoro-3'-nitroacetophenone

4'-Fluoro-3'-nitroacetophenone

Product Name
4'-Fluoro-3'-nitroacetophenone
CAS No.
400-93-1
Chemical Name
4'-Fluoro-3'-nitroacetophenone
Synonyms
4′-Fluor-3′-nitroacetophenon;4-Fluoro-3-nitroacetophneone;4-FLUORO-3-NITROACETOPHENONE;4-FLUORO-3'-NITROACETOPHENONE;4'-Fuoro-3'-nitroacetophenone;4'-Fluoro-3'-notroacetophenone;4'-Fluoro-3'-nitroacetophenone;4'-Fluoro-3'-nitroacetophenone>4'-Fluoro-3'-nitroacetophenone,98%;1-(4-FLUORO-3-NITRO-PHENYL)-ETHANONE
CBNumber
CB0154158
Molecular Formula
C8H6FNO3
Formula Weight
183.14
MOL File
400-93-1.mol
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4'-Fluoro-3'-nitroacetophenone Property

Melting point:
47-51 °C
Boiling point:
118-120°C 0,8mm
Density 
1.336±0.06 g/cm3(Predicted)
Flash point:
118-120°C/0.8mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
Crystalline Powder
color 
Light yellow
BRN 
2211976
InChIKey
PTCNZDJJIOLIKQ-UHFFFAOYSA-N
CAS DataBase Reference
400-93-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29143990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
676357
Product name
4′-Fluoro-3′-nitroacetophenone
Purity
97%
Packaging
1g
Price
$44.8
Updated
2023/01/07
Sigma-Aldrich
Product number
676357
Product name
4′-Fluoro-3′-nitroacetophenone
Purity
97%
Packaging
5g
Price
$204
Updated
2023/01/07
TCI Chemical
Product number
F0777
Product name
4'-Fluoro-3'-nitroacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$70
Updated
2025/07/31
TCI Chemical
Product number
F0777
Product name
4'-Fluoro-3'-nitroacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$276
Updated
2025/07/31
TRC
Product number
F489640
Product name
4''-​Fluoro-​3''-​nitroacetophenone
Packaging
5g
Price
$85
Updated
2021/12/16
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4'-Fluoro-3'-nitroacetophenone Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline powder

Uses

4''-?Fluoro-?3''-?nitroacetophenone is used as reactant/reagent in preparation of substituted furans via copper-catalyzed radical addition of acetophenones to alkynes.

Synthesis

403-42-9

400-93-1

General procedure for the synthesis of 4-fluoro-3-nitroacetophenone from 4-fluoroacetophenone: 1-(4-fluorophenyl)ethanone (1.10 g, 7.97 mmol) was dissolved in concentrated H2SO4 (5 mL) under stirring conditions. Subsequently, a mixed acid consisting of concentrated HCl and concentrated H2SO4 (2 mL) was slowly added. HNO3 (1.50 mL) was added slowly and dropwise at -15°C. The reaction mixture was continued to be stirred at -15 °C for 80 min, after which it was poured into ice-cold H2O (120 mL) and extracted with EtOAc (2 × 100 mL). The organic layers were combined and washed sequentially with H2O (100 mL) and brine (100 mL), and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 100-200 mesh, 40% EtOAc in hexane solution) to afford 4-fluoro-3-nitroacetophenone (0.80 g, 55%) as an off-white solid.1H NMR (400 MHz, CDCl3) δ 2.64 (s, 3H), 7.39 (t, J=9.30 Hz, 1H), 8.20- 8.26 (m, 1H), 8.57-8.66 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1725 - 1728
[2] Patent: WO2017/89453, 2017, A1. Location in patent: Page/Page column 55
[3] Patent: WO2007/103260, 2007, A1. Location in patent: Page/Page column 63-64
[4] Archiv der Pharmazie (Weinheim, Germany), 1957, vol. 290, p. 587,595
[5] Archiv der Pharmazie, 1963, vol. 296, p. 324 - 336

4'-Fluoro-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Fluoro-3'-nitroacetophenone Suppliers

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View Lastest Price from 4'-Fluoro-3'-nitroacetophenone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4'-Fluoro-3'-nitroacetophenone 400-93-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2025-03-14
Shaanxi Dideu Medichem Co. Ltd
Product
4'-Fluoro-3'-nitroacetophenone 400-93-1
Price
US $1.00-12.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2024-07-26
Honest Joy Holdings Limited
Product
4'-Fluoro-3'-nitroacetophenone 400-93-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.1%
Supply Ability
100 tons
Release date
2022-02-20

400-93-1, 4'-Fluoro-3'-nitroacetophenoneRelated Search:

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  • 400-93-1
  • C8H6FNO3
  • Ketones
  • Organic Building Blocks
  • C7 to C8
  • Carbonyl Compounds
  • Building Blocks
  • C7 to C8
  • Miscellaneous
  • ketone
  • Carbonyl Compounds
  • Ketones
  • Acetophenone series