Chloramine-T Property

Melting point:

167-170 °C(lit.)

Density 

1.401[at 20℃]

vapor pressure 

0Pa at 25℃

storage temp. 

Sealed in dry,2-8°C

solubility 

H₂O: >100 mg/mL

pka

0.39[at 20 ℃]

form 

Solid

color 

White to off-white

Water Solubility 

150g/L at 25℃

Stability:

Stable. Incompatible with strong oxidizing agents. May decompose violently if heated above 130 C. May decompose on exposure to air.

InChI

InChI=1S/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1

InChIKey

VDQQXEISLMTGAB-UHFFFAOYSA-N

SMILES

S(=O)(=O)(N(Cl)[Na])C1C=CC(C)=CC=1

LogP

-1.3 at 20℃

CAS DataBase Reference

127-65-1(CAS DataBase Reference)

EPA Substance Registry System

Chloramine T (127-65-1)

Safety

Hazard Codes 

C,Xn

Risk Statements 

22-31-34-42

Safety Statements 

22-26-36/37/39-45-7-1/2

RIDADR 

UN 3263 8/PG 3

WGK Germany 

2

HazardClass 

8

PackingGroup 

III

HS Code 

29242990

Hazardous Substances Data

127-65-1(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Chloramine-T Chemical Properties,Usage,Production

Description

The sodium salt of p-toluenesulfochloramide, commonly known as chloramine-T, exerts strong oxidizing action in both acidic and alkaline media and thus has been widely used for the oxidimetric determination of a large number of inorganic and organic substances. Oxidation of some aldehydes by chloramine-T has been reported to occur quantitatively in an alkaline solution, giving the corresponding acid as the end product. Both direct and indirect methods have been carried out to estimate aldehydes by chloramine-T. Chloramine-T (CAT) is also commonly used in radiolabeling bioactive molecules by halogenation. CAT is used to release radioactive elemental iodine by oxidation of its salts. Unfortunately, CAT is a strong oxidizing agent and can cause significant damage to peptides and proteins. This may lower the yield of the iodination reaction and may produce undesirable side products[1-2]. 

Chemical Properties

white or yellow powder with a chlorine-like odour

Uses

antiseptic, disinfestant, antiproliferative

Uses

This disinfectant is for external use only, it can exterminate bacteria, viruses, fungi, spore. The action principle is that chlorine can sterilize slowly and lastingly, and also can dissolve necrotic tissue, chlorine come from hypochlorous acid which is produced by Chloramine-T solution. Apply to disinfect drinking water container,food,all kind of tableware, fruits and vegetables,and cleaning wound, mucous membrane.

Uses

sterilizer, antiseptic, disinfectant, and chemical reagent in the medical and pharmaceutical fields.

Definition

ChEBI: An organic sodium salt derivative of toluene-4-sulfonamide with a chloro substituent in place of an amino hydrogen.

Flammability and Explosibility

Not classified

Safety Profile

Poison by parenteral and intravenous routes. Human mutagenic data reported. When heated to decomposition it emits toxic fumes of Cl-, SOx, Na2O, and NOx. See also SULFONATES and CHLORIDES.

Synthesis

Chloramine-T is prepared in 75 – 95 % yield by passing chlorine into a sodium hydroxide solution of p-toluenesulfonamide. It is a strong electrolyte in acid solution and a good oxidizing agent in base. It is fairly soluble in water, and practically insoluble in benzene, chloroform, and ether. The compound reacts readily with mustard gas to yield a harmless crystalline sulfimide; chloramine-T derivatives are being studied as protective agents against poison gas.

References

[1] M. C. Agrawal, S. P. Mushran. "Mechanism of Oxidation of some Aliphatic Aldehydes by Chloramine-T." Zeitschrift für Naturforschung B 20 1 (1972): 401–404.
[2] B M Tashtoush. "Chloramine-T in radiolabeling techniques. IV. Penta-O-acetyl-N-chloro-N-methylglucamine as an oxidizing agent in radiolabelling techniques." Analytical biochemistry 288 1 (2001): 16–21.