4-Nitrophenyl chloroformate
- Product Name
- 4-Nitrophenyl chloroformate
- CAS No.
- 7693-46-1
- Chemical Name
- 4-Nitrophenyl chloroformate
- Synonyms
- 4-NITROPHENYL CARBONOCHLORIDATE;P-NITROPHENYL CHLOROFORMATE;PNPCF;Nitrophenyl chloroforMate;4-Nitrophenyl chloridocarbonate;4-NITROPHENYL CHLOROCARBONATE;PARA-NITROPHENYL CHLOROFORMATE;CHLOROFORMIC ACID P-NITROPHENYL ESTER;CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER;p-Nitrophenyl c
- CBNumber
- CB7348509
- Molecular Formula
- C7H4ClNO4
- Formula Weight
- 201.56
- MOL File
- 7693-46-1.mol
4-Nitrophenyl chloroformate Property
- Melting point:
- 77-79 °C(lit.)
- Boiling point:
- 159-162 °C19 mm Hg(lit.)
- Density
- 1.5719 (rough estimate)
- refractive index
- 1.6000 (estimate)
- Flash point:
- >110°C
- storage temp.
- 2-8°C
- solubility
- Soluble in acetone, chloroform, acetone, toluene and benzene.
- form
- isopropanol suspension
- color
- White to yellow-beige
- Water Solubility
- decomposes
- Sensitive
- Lachrymatory
- BRN
- 518127
- Stability:
- Stable. Incompatible with strong bases, acids. Combustible.
- CAS DataBase Reference
- 7693-46-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
- EPA Substance Registry System
- Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)
Safety
- Hazard Codes
- C,T,Xi,F
- Risk Statements
- 34-36/37-23/24/25-41-36/37/38-11-67-36
- Safety Statements
- 26-36/37/39-45-38-28A-36-16-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 19-21
- Hazard Note
- Toxic/Corrosive/Lachrymator
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29159020
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 160210
- Product name
- 4-Nitrophenyl chloroformate
- Purity
- 96%
- Packaging
- 5g
- Price
- $75.4
- Updated
- 2024/03/01
- Product number
- 160210
- Product name
- 4-Nitrophenyl chloroformate
- Purity
- 96%
- Packaging
- 25g
- Price
- $227
- Updated
- 2024/03/01
- Product number
- C1400
- Product name
- 4-Nitrophenyl Chloroformate
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $104
- Updated
- 2024/03/01
- Product number
- C1400
- Product name
- 4-Nitrophenyl Chloroformate
- Purity
- >98.0%(T)
- Packaging
- 250g
- Price
- $646
- Updated
- 2024/03/01
- Product number
- A18742
- Product name
- 4-Nitrophenyl chloroformate, 97%
- Packaging
- 5g
- Price
- $44.9
- Updated
- 2024/03/01
4-Nitrophenyl chloroformate Chemical Properties,Usage,Production
Chemical Properties
Cream solid
Uses
4-Nitrophenyl chloroformate can be used:
- As a reagent for the activation of amines, alcohols and thiols.
- In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
- In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
- In the preparation of poly(oxyethylene) modified dextrans.
- To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.
Uses
4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane. It is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.
Application
4-Nitrophenyl chloroformate is used as:A coupling agent to link the drug molecule with the polyrotaxane carrier molecule.As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF).
Description
4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.
4-Nitrophenyl chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Nitrophenyl chloroformate manufacturers
- Product
- 4-Nitrophenyl chloroformate 7693-46-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 4-Nitrophenyl chloroformate 7693-46-1
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 4-Nitrophenyl chloroformate 7693-46-1
- Price
- US $25.00-15.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2023-10-25