Chondroitin 4-sulfate

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Chondroitin 4-sulfate

Product Name: Chondroitin 4-sulfate
CAS No.: 24967-93-9
Chemical Name: Chondroitin 4-sulfate
Synonyms: turkadon;Chodroitin Sulfate;chondroitinasulfate;ChondroitinSulphateA;Chondroitine sulfate;CHONDROITIN SULFATE A;CHONDROITIN-4-SULFATE;chondroitinsulfatetypea;CSAChondroitin-4-sulfate;chondroitinsulfuricacida
CBNumber: CB7352434
Molecular Formula: (C14H19NO14SNa2)n
Formula Weight: 499.38
MOL File: Mol file

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Chondroitin 4-sulfate Property

alpha: D -28 to -32°
storage temp.: 2-8°C
solubility: H₂O: 0.1 g/mL, slightly hazy, faintly yellow

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Safety

WGK Germany: 3
F: 3-10
Toxicity: mouse,LD,oral,> 15gm/kg (15000mg/kg),Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 58, Pg. 739, 1978.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb105119
Product name: Chondroitin 4-sulfate
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

DC Chemicals

Product number: DCL-038
Product name: Chondroitin4-sulfate
Purity: >98%,StandardReferencesGrade
Packaging: 20mg
Price: $280
Updated: 2021/12/16

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Chondroitin 4-sulfate Chemical Properties,Usage,Production

Description

Chondroitin 4-sulfate is a natural polymer of a disaccharide consisting of glucuronic acid and N-acetyl glucosamine which is sulfated either in the 4 or 6 position. It is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).

Chemical Properties

White or yellowish amorphous powder. Tasteless, odorless, hygroscopic, soluble in water, insoluble in organic solvents such as ethanol, acetone, ether, etc. Optical rotation -25°-+35°(c=1, H2O). There are characteristic absorption peaks at 725cm-1, 852cm-1 and 930cm-1 by infrared spectroscopy.

Uses

sodium chondroitin sulfate is described as a skin-conditioning agent, with possible anti-inflammatory properties. It can be found in such products as moisturizers and night skin care preparations. It is a derivative of natural mucopolysaccharides. Chondroitin 4-sulfate is an important structural component of cartilage and has been used as a dietary supplement to treat symptoms of joint discomfort.

Preparation

Chondroitin 4-sulfate can be extracted using the following method:
Weigh pig throat and nasal cartilage and put it into a solution of 20g/L (2%) sodium hydroxide, using a ratio of 5 times the weight of the cartilage.
Soak the cartilage in the sodium hydroxide solution and stir it intermittently.
Filter the solution when the leachate reaches 5.5°Be.
Extract the residue left on the filter by adding it to the sodium hydroxide solution again and combining the filtrate.
To remove impurities such as protein, hydrolyze the solution with crude trypsin at 50°C.
Filter the solution until it becomes clear.
Adjust the pH of the solution to 6.
Add ethanol to the solution until the alcohol content reaches 75%.
Let the solution stand overnight to allow precipitation.
Centrifuge the solution to separate the precipitate.
Wash the precipitate with absolute ethanol.
Dry the precipitate at 60°C to obtain crude chondroitin sulfate.

Definition

ChEBI: Chondroitin 4'-sulfate is a chondroitin sulfate in which the site of sulfation is carbon 4 of the N-acetylgalactosamine (GalNAc) sugar. It has a role as a mouse metabolite. It is a conjugate acid of a chondroitin 4'-sulfate anion.

References

1. Inhibition of Spiral Growth and Dissolution at the Brushite (010) Interface by Chondroitin 4-Sulfate. DOI:10.1021/acs.jpcb.8b11531
2. Evaluation of Chitosan-Based Films Containing Gelatin, Chondroitin 4-Sulfate and ZnO for Wound Healing. DOI:10.1007/s12010-017-2462-z
3. Expression and function of chondroitin 4‐sulfate and chondroitin 6‐sulfate in human glioma. DOI:10.1096/fj.201901621RRR
4. https://pubchem.ncbi.nlm.nih.gov/compound/70678540

Chondroitin 4-sulfate Preparation Products And Raw materials

Raw materials

Strong acid styrene cation exchange resin Α-protein Pancreatin

Preparation Products

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View Lastest Price from Chondroitin 4-sulfate manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Chondroitin 4-sulfate 24967-93-9
Price: US $55.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2021-06-08

zhuzhou dingcheng meihei comestic co.,ltd

Product: sodium chondroitin sulfate 24967-93-9
Price: US $33.00/Box
Min. Order: 1Box
Purity: 99.99%
Supply Ability: 10000000000
Release date: 2024-01-04

Zibo Wei Bin Import & Export Trade Co. Ltd.

Product: Chondroitin sulfate 24967-93-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1t
Release date: 2023-07-11

24967-93-9, Chondroitin 4-sulfateRelated Search:

Neomycin sulfate calcium sulfate Sodium sulfate Potassium sulfate Ammonium sulfate Ferrous sulfate monohydrate Chondroitin sulfate sodium salt sulfate Heparitin, sulfate chondroitin sulfate SALCOMINE Ethyl isocyanoacetate Benzyl isocyanide N-BUTYLISOCYANIDE TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate Tosylmethyl isocyanide

SODIUM CHONDROITIN SULFATE

ChondroitinSulphateA

CSAChondroitin-4-sulfate

CHONDROITIN SULFATE A ORAL (FROM BEEF TRACHEA)

CHONDROITIN SULFATE A SODIUM SALT(RG)

Chondroitin sulfate sodium salt (bovine)

Chondroitine sulfate

Colistin sulfate, PolyMyxin E

Chondritin Sulfate A,Bovine Trachea

Chodroitin Sulfate

turkadon

CHONDROITIN SULFATE A

CHONDROITIN SULFATE A, BOVINE

CHONDROITIN SULFATE A, BOVINE TRACHEA

CHONDROITIN SULFATE A ORAL

CHONDROITIN-4-SULFATE

CHONDROITIN-4-SULFATE, BOVINE

CHONDROITIN 4-SULFATE SODIUM SALT

chondroitin,4-(hydrogensulfate)

chondroitin-4-sulfuricacid

chondroitinasulfate

chondroitinsulfatetypea

chondroitinsulfuricacida

chondroitinsulfuricacids,typea

chondroitinsulfuricacidtypea

Chondroitin 4-sulfate USP/EP/BP

discount Chondroitin 4-sulfate

24967-93-9

C14H19O14NSNa2n

H2OC14H21NO14Sn

C14H21NO14Sn

Carbohydrate

BioChemical

Metabolites and Cofactors on the Metabolic Pathways Chart

Metabolic Pathways

Metabolomics

Natural Plant Extract