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3-(BROMOMETHYL)PHENOL

Product Name
3-(BROMOMETHYL)PHENOL
CAS No.
74597-04-9
Chemical Name
3-(BROMOMETHYL)PHENOL
Synonyms
AKOS 90890;3-(BROMOMETHYL)PHENOL;m-(Bromomethyl)phenol;3-Hydroxybenzylbromide;Phenol, 3-(bromomethyl)-;3-(Bromomethyl)phenol CAS NO.74597-04-9;6-Quinolinesulfonylchloride,1,2-dihydro-4-oxo-
CBNumber
CB7365827
Molecular Formula
C7H7BrO
Formula Weight
187.03
MOL File
74597-04-9.mol
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3-(BROMOMETHYL)PHENOL Property

Boiling point:
272℃
Density 
1.593
Flash point:
118℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
9.55±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

RIDADR 
2810
HazardClass 
6.1
PackingGroup 
Ⅱ
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B808033
Product name
3-​(Bromomethyl)​phenol
Packaging
250mg
Price
$165
Updated
2021/12/16
AK Scientific
Product number
Y9989
Product name
3-(Bromomethyl)phenol
Packaging
1g
Price
$550
Updated
2021/12/16
Matrix Scientific
Product number
188374
Product name
3-(Bromomethyl)phenol
Packaging
1g
Price
$780
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0142867
Product name
3-(BROMOMETHYL)PHENOL
Purity
98.00%
Packaging
1G
Price
$1339.8
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0142867
Product name
3-(BROMOMETHYL)PHENOL
Purity
98.00%
Packaging
5G
Price
$1501.5
Updated
2021/12/16
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3-(BROMOMETHYL)PHENOL Chemical Properties,Usage,Production

Uses

3-?(Bromomethyl)?phenol is a reagent used in synthesis of furan-based heterocycles. Also used in the preparation of tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptors.

Synthesis

620-24-6

74597-04-9

General procedure for the synthesis of m-hydroxybenzyl bromide from 3-hydroxybenzyl alcohol: Synthesis of Intermediate 17: 3-(bromomethyl)phenol A 50 mL round bottom flask was charged with 15 mL of dichloromethane and fitted with a magnetic stirrer. To the stirred solvent was added 3-hydroxymethylphenol (0.5 g, 4.03 mmol). After cooling the reaction mixture to 0°C, phosphorus tribromide (1.6 g, 0.56 mL, 6.04 mmol) was added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction mixture was diluted with 25 mL of dichloromethane and the organic layer was washed with 20 mL of water. The organic layer was dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent to give a brown solid product (0.65 g, yield: 86.3%). Mass spectrum (ESI, 120 eV): m/z = 187.0 (M + H)+. 1H NMR (300MHz, CDCl3): δ 7.10-7.15 (t, 1H), 6.86-6.89 (d, 1H), 6.80 (d, 1H), 6.67-6.71 (m, 1H), 4.35-4.36 (d, 2H), 3.80-3.94 (broad peak, 1H).

References

[1] Chemische Berichte, 1989, vol. 122, p. 347 - 356
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 70; 71-72
[3] Patent: WO2014/31936, 2014, A2. Location in patent: Paragraph 0327; 0328
[4] Patent: WO2014/31928, 2014, A2. Location in patent: Paragraph 0334
[5] Patent: WO2005/68421, 2005, A1. Location in patent: Page/Page column 39-40

3-(BROMOMETHYL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(BROMOMETHYL)PHENOL Suppliers

China 73 Germany 1 India 2 United States 6 Global 82
Aladdin Scientific
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tp@aladdinsci.com
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United States
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52923
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Synthonix Inc
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info@synthonix.com
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United States
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6872
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3B Scientific Corporation
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sales@3bsc.com
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United States
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3B Scientific Corporation
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sales@3bsc.com
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United States
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Milestone PharmTech LLC
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Frontier Scientific, Inc.
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74597-04-9, 3-(BROMOMETHYL)PHENOLRelated Search:

4,5-DIMETHOXY-2-NITROBENZYL BROMIDE 3,5-DIMETHOXYBENZYL BROMIDE 3-(BROMOMETHYL)PHENOXYACETIC ACID 3-BENZYLOXYBENZYL BROMIDE 2-BROMO-5-METHOXYBENZYL BROMIDE 97 3-METHOXYBENZYL BROMIDE 3-(Trifluoromethoxy)benzyl bromide 1-(BROMOMETHYL)-3-PHENOXYBENZENE 3-(DIFLUOROMETHOXY)BENZYL BROMIDE 2-(BROMOMETHYL)PHENOL 4-(BROMOMETHYL)PHENOL,p-(Bromomethyl)phenol 7-BROMOMETHYL-4-METHYL-CHROMEN-2-ONE 3,5-BIS[3,5-BIS(BENZYLOXY)BENZYLOXY]BENZYL BROMIDE 3-(2-FLUOROPHENOXY)BENZYL BROMIDE 3,5-DI(BROMOMETHYL)PHENOL 3,5-BIS(BENZYLOXY)BENZYL BROMIDE 4-[2-(3,4-DIMETHOXYPHENYL)-1,2-DIBROMOETHYL]-1,2-DIMETHOXYBENZENE 3-(4-FLUOROPHENOXY)BENZYL BROMIDE

  • 3-(BROMOMETHYL)PHENOL
  • AKOS 90890
  • 3-Hydroxybenzylbromide
  • m-(Bromomethyl)phenol
  • Phenol, 3-(bromomethyl)-
  • 6-Quinolinesulfonylchloride,1,2-dihydro-4-oxo-
  • 3-(Bromomethyl)phenol CAS NO.74597-04-9
  • 74597-04-9