ChemicalBook > CAS DataBase List > Ethyl 3-amino-4-pyrazolecarboxylate

Ethyl 3-amino-4-pyrazolecarboxylate

Product Name: Ethyl 3-amino-4-pyrazolecarboxylate
CAS No.: 6994-25-8
Chemical Name: Ethyl 3-amino-4-pyrazolecarboxylate
Synonyms: Ethyl 3-amino-1H-pyrazole-4-carboxylate;ETHYL 5-AMINO-1H-PYRAZOLE-4-CARBOXYLATE;Allopurinol Related Compound D;5-Amino-1H-pyrazole-4-carboxylic acid;AMINAZOLE;INDIP-014;(19750-02-8;AKOS B001005;AKOS BC-0708;e-4-carboxyL
CBNumber: CB7371660
Molecular Formula: C6H9N3O2
Formula Weight: 155.15
MOL File: 6994-25-8.mol

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Ethyl 3-amino-4-pyrazolecarboxylate Property

Melting point:: 105-107 °C(lit.)
Boiling point:: 278.95°C (rough estimate)
Density: 1.3092 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Crystalline Powder
pka: 12.98±0.50(Predicted)
color: White to yellow
BRN: 4964
Stability:: Light sensitive
InChI: InChI=1S/C6H9N3O2/c1-2-11-6(10)4-3-8-9-5(4)7/h3H,2H2,1H3,(H3,7,8,9)
InChIKey: YPXGHKWOJXQLQU-UHFFFAOYSA-N
SMILES: N1C=C(C(OCC)=O)C(N)=N1
CAS DataBase Reference: 6994-25-8(CAS DataBase Reference)
NIST Chemistry Reference: 3-Amino-4-carbethoxypyrazole(6994-25-8)

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Safety

Hazard Codes: Xi,Xn,N
Risk Statements: 36/37/38-20/21/22-50/53-43
Safety Statements: 26-36-24/25-61-60-36/37
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP844
Product name: Allopurinol impurity D
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 10MG
Price: $248
Updated: 2025/07/31

Sigma-Aldrich

Product number: A45009
Product name: Ethyl 3-aminopyrazole-4-carboxylate
Purity: 98%
Packaging: 5g
Price: $35
Updated: 2025/07/31

Sigma-Aldrich

Product number: A0350040
Product name: Allopurinol impurity D
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1013046
Product name: Allopurinol Related Compound D
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 35mg
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: E0766
Product name: Ethyl 3-Aminopyrazole-4-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $89
Updated: 2025/07/31

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Ethyl 3-amino-4-pyrazolecarboxylate Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

Ethyl 3-Amino-4-pyrazolecarboxylate (Allopurinol EP Impurity D) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Synthesis

94-05-3

1260243-04-6

General procedure for the synthesis of ethyl 5-amino-1H-pyrazole-4-carboxylate from ethyl ethoxymethylcyanoacetate: ethyl ethoxymethylcyanoacetate (68 g, 0.4 mol) was added to a reaction vessel containing 200 mL of anhydrous ethanol; 100 mL of hydrazine hydrate was added slowly and dropwise to the reaction vessel. The reaction mixture was placed in an electric heating jacket and gradually heated up to 80 °C within 30 min to obtain mixture A. The mixture A was heated to reflux and kept in reflux reaction for 4 h. The reaction was carried out under reduced pressure. Upon completion of the reaction, ethanol was removed by distillation under reduced pressure and the remaining solid was concentrated by evaporation. The concentrated solid was cooled to room temperature and left to precipitate a light yellow solid, which was filtered, washed and dried to give the intermediate ethyl 5-amino-1H-pyrazole-4-carboxylate. Cold anhydrous ethanol was used for the washing process. The mass of the final product ethyl 5-amino-1H-pyrazole-4-carboxylate was 41.68 g and the yield was 66.78%.

References

[1] Patent: CN105949202, 2016, A. Location in patent: Paragraph 0048-0053
[2] Patent: CN106008517, 2016, A. Location in patent: Paragraph 0048; 0049; 0050; 0051; 0052; 0053
[3] Patent: CN106008519, 2016, A. Location in patent: Paragraph 0048; 0049; 0050; 0051; 0052; 0053
[4] Patent: CN105949199, 2016, A. Location in patent: Paragraph 0047-0052
[5] Patent: CN105949200, 2016, A. Location in patent: Page/Page column 6; 7; 23

Ethyl 3-amino-4-pyrazolecarboxylate Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Triethyl orthoformate HYDRAZINE Acetic acid Ethyl (ethoxymethylene)cyanoacetate Ethyl cyanoacetate

Preparation Products

Allopurinol

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View Lastest Price from Ethyl 3-amino-4-pyrazolecarboxylate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ethyl 3-amino-4-pyrazolecarboxylate 6994-25-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-23

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 3-amino-4-pyrazolecarboxylate 6994-25-8
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Ethyl 3-amino-4-pyrazolecarboxylate 6994-25-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-14

6994-25-8, Ethyl 3-amino-4-pyrazolecarboxylateRelated Search:

ethyl 5-(forMylaMino)-1H-pyrazole-4-carboxylate 5-(forMylaMino)-1H-pyrazole-4-carboxaMide 5-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-Aminopyrazole 4-Pyrazolecarboxylic acid 3-Aminopyrazole-4-carboxylic acid Ethyl pyrazole-4-carboxylate 4-AMINO-2 H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Oxipurinol Allopurinol Impurity 1 ALLOPURINOL IMPURITY C Allopurinol Related CoMpound F Allopurinol-d2 Allopurinol Oxypurinol -13C, 15N2 ALLOPURINOL RIBOSIDE 3-Amino-1H-pyrazole-4-carboxamide 5-[(1-Methylpiperidin-2-ylidene)amino]-1H-pyrazole-4-carboxylic acid ethyl ester

JR-8260, 3-Amino-4-carbethoxypyrazole, 97%

Ethyl 5-amino-1H-pyrazole-4-carboxylate 97%

Allopurinol EP Impurity D (USP RC D)

Allopurinol EP IMpurity D

3- aMino-4- pyrazoleethyl forMate

5-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(Ethyl 3-amino-4-pyrazolecarboxylate)

Ethyl3-amino-1H-pyrazole-4-carboxylate,99%

AKOS BC-0708

AKOS BBS-00002579

AMINAZOLE

AKOS B001005

5-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

3-AMINO-4-CARBETHOXYPYRAZOL

3-AMINO-4-CARBETHOXYPYRAZOLE

3-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

3-AMINOPYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

1H-PYRAZOLE-4-CARBOXYLIC ACID, 3-AMINO-, ETHYL ESTER

ETHYL 3-AMINOPYRAZOLE-4-CARBOXYLATE

ETHYL 3-AMINO-4-PYRAZOLECARBOXYLATE

ETHYL 5-AMINO-1H-PYRAZOLE-4-CARBOXYLATE

BUTTPARK 100\09-33

3-Amino-4-ethoxycarbonylpyrazole

Ethyl 3-amino-1H-pyrazole-4-carboxylate

TIMTEC-BB SBB001936

Ethyl 3-amino-4-pyarazolecarboxylate

3-Amino-4-pyrazolecarboxylate

3-Amino-4-(ethoxycarbonyl)-1H-pyrazole, 3-Amino-4-carbethoxy-1H-pyrazole

Ethyl 5-aminopyrazol-4-carboxylate

INDIP-014

Allopurinol Impurity 4(Allopurinol EP Impurity D)(Allopurinol USP Related Compound D )

Ethyl 3-aminopyrazole-4-carboxylate 98%

3-amino-2H-pyrazole-4-carboxylic acid ethyl ester

Allopurinol Related Compound D

3-Amino-4-Carbethyloxypyrazole

5-Amino-1H-pyrazole-4-carboxylic acid

ethyl 3-amino-2H-pyrazole-4-carboxylate

Ethyl 3-amino-4-pyrazolecarboxylate ,99%

3-AMINO-4-CARBETHOXYPYRAZOLE ,99%

ethyl 5-amino-1H-pyrazole-4-carboxylate(SALTDATA: FREE)

ethyl 3-amino-1H-pyrazole-4-carboxylate(SALTDATA: FREE)

3-Amino-4-carboethoxy-1H-pyrazole

Ethyl 2-aminopyrazole-3-carboxylate

Allopurinol Related Compound D (35 mg) (ethyl 5-amino-1H-pyrazole-4-carboxylate)

4-(ethoxyMethyl)-1H-pyrazol-3-aMine

3-AMino-4-carbethoxypyrazole, 99% 5GR

1H-pyrazole-4-carboxylic acid, 5-amino-, ethyl ester

ETHYL (3-AMINOPYRAZOLE 4-CARBOXYLATE) FO

(19750-02-8

Allopurinol EP Imp D

Allopurinol EP Impurity D or Allopurinol USP Related Compound D

Allopurinol EP Impurity D（Allopurinol USP Related Compound D）

e-4-carboxyL

Ethyl 3-Amino-4-pyrazolecarboxylate &gt

Allopurinol impurity D CRS

Ethyl-3-amino-1H-pyrazol-4-carboxylat

Allopurinol EP impurity D/ Allopurinol Related Compound D

Allopurinol Impurity1580

Allopurinol impurity D (A0350040)