3-Amino-1H-pyrazole-4-carboxamide
- Product Name
- 3-Amino-1H-pyrazole-4-carboxamide
- CAS No.
- 5334-31-6
- Chemical Name
- 3-Amino-1H-pyrazole-4-carboxamide
- Synonyms
- 3-AMINOPYRAZOLE-4-CARBOXAMIDE;Allopurinol EP IMpurity A;3-Amino-4-carbamoylpyrazole;3-AMino-1H-pyrazole-4-car...;5-Amino-1H-pyrazole-4-car...;5-Amino-4-pyrazolecarboxamide;3-Amino-1H-pyrazole-4-formamide;3-Amino-1H-pyrazole-4-carboxamide;5-azanyl-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 3-amino-
- CBNumber
- CB9244036
- Molecular Formula
- C4H6N4O
- Formula Weight
- 126.12
- MOL File
- 5334-31-6.mol
3-Amino-1H-pyrazole-4-carboxamide Property
- Melting point:
- 187-189 °C(Solv: water (7732-18-5))
- Boiling point:
- 454.3±25.0 °C(Predicted)
- Density
- 1.538±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 13.26±0.50(Predicted)
- color
- Off-White to Pale Beige
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A628745
- Product name
- 5-Amino-4-pyrazolecarboxamide
- Packaging
- 10g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- OR16676
- Product name
- 3-Amino-1H-pyrazole-4-carboxamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H58-1-4B
- Product name
- 3-Amino-1H-pyrazole-4-carboxamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR16676
- Product name
- 3-Amino-1H-pyrazole-4-carboxamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 4H58-1-4B
- Product name
- 3-Amino-1H-pyrazole-4-carboxamide
- Purity
- 98%
- Packaging
- 5G
- Price
- $44
- Updated
- 2021/12/16
3-Amino-1H-pyrazole-4-carboxamide Chemical Properties,Usage,Production
Uses
5-Amino-4-pyrazolecarboxamide is used in the synthesis of 4H-3,1-Benzothiazinone analogs as antiproliferative agents against human cancer cell lines. Also, it is an intermediate used in the synthesis of 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (T767570), which is an impurity of Allopurinol (A547300), which is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.
Synthesis
16617-46-2
5334-31-6
General procedure for the synthesis of 3-aminopyrazole-4-carboxamide from 3-amino-4-cyanopyrazole: 5-amino-1H-pyrazole-4-carbonitrile (1) (5 g, 0.046 mol) was slowly added to pre-cooled concentrated sulfuric acid (10 ml) under stirring conditions, and the temperature of the reaction was controlled not to exceed 20 °C. After the addition was completed, the reaction mixture was stirred continuously at room temperature for 4 hours. Subsequently, the reaction solution was slowly poured into ice water under stirring and the mixture was allowed to stand in a refrigerator overnight. The precipitated solid product was collected by filtration and washed with water to remove residual sulfuric acid, which ultimately yielded the target compound 5-amino-1H-pyrazole-4-carboxamide (2) as a white solid with a yield of 5.19 g in 89% yield; melting point 220-222 °C (literature value 222-225 °C) [33].
References
[1] Bioorganic Chemistry, 2018, vol. 79, p. 46 - 59
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 24 - 35
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1191 - 1196
3-Amino-1H-pyrazole-4-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-1H-pyrazole-4-carboxamide manufacturers
- Product
- 3-Amino-1H-pyrazole-4-carboxamide 5334-31-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-02