ChemicalBook > CAS DataBase List > 3-Amino-1H-pyrazole-4-carboxamide

3-Amino-1H-pyrazole-4-carboxamide

Product Name
3-Amino-1H-pyrazole-4-carboxamide
CAS No.
5334-31-6
Chemical Name
3-Amino-1H-pyrazole-4-carboxamide
Synonyms
3-AMINOPYRAZOLE-4-CARBOXAMIDE;Allopurinol EP IMpurity A;3-Amino-4-carbamoylpyrazole;3-AMino-1H-pyrazole-4-car...;5-Amino-1H-pyrazole-4-car...;5-Amino-4-pyrazolecarboxamide;3-Amino-1H-pyrazole-4-formamide;3-Amino-1H-pyrazole-4-carboxamide;5-azanyl-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 3-amino-
CBNumber
CB9244036
Molecular Formula
C4H6N4O
Formula Weight
126.12
MOL File
5334-31-6.mol
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3-Amino-1H-pyrazole-4-carboxamide Property

Melting point:
187-189 °C(Solv: water (7732-18-5))
Boiling point:
454.3±25.0 °C(Predicted)
Density 
1.538±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Very Slightly)
form 
Solid
pka
13.26±0.50(Predicted)
color 
Off-White to Pale Beige
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A628745
Product name
5-Amino-4-pyrazolecarboxamide
Packaging
10g
Price
$185
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027896
Product name
3-AMINOPYRAZOLE-4-CARBOXAMIDE
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027896
Product name
3-AMINOPYRAZOLE-4-CARBOXAMIDE
Purity
95.00%
Packaging
2.5G
Price
$852.21
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027896
Product name
3-AMINOPYRAZOLE-4-CARBOXAMIDE
Purity
95.00%
Packaging
5G
Price
$1005.43
Updated
2021/12/16
Apolloscientific
Product number
OR16676
Product name
3-Amino-1H-pyrazole-4-carboxamide
Purity
98%
Packaging
1g
Price
$15
Updated
2021/12/16
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3-Amino-1H-pyrazole-4-carboxamide Chemical Properties,Usage,Production

Uses

5-Amino-4-pyrazolecarboxamide is used in the synthesis of 4H-3,1-Benzothiazinone analogs as antiproliferative agents against human cancer cell lines. Also, it is an intermediate used in the synthesis of 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (T767570), which is an impurity of Allopurinol (A547300), which is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.

Synthesis

16617-46-2

5334-31-6

General procedure for the synthesis of 3-aminopyrazole-4-carboxamide from 3-amino-4-cyanopyrazole: 5-amino-1H-pyrazole-4-carbonitrile (1) (5 g, 0.046 mol) was slowly added to pre-cooled concentrated sulfuric acid (10 ml) under stirring conditions, and the temperature of the reaction was controlled not to exceed 20 °C. After the addition was completed, the reaction mixture was stirred continuously at room temperature for 4 hours. Subsequently, the reaction solution was slowly poured into ice water under stirring and the mixture was allowed to stand in a refrigerator overnight. The precipitated solid product was collected by filtration and washed with water to remove residual sulfuric acid, which ultimately yielded the target compound 5-amino-1H-pyrazole-4-carboxamide (2) as a white solid with a yield of 5.19 g in 89% yield; melting point 220-222 °C (literature value 222-225 °C) [33].

References

[1] Bioorganic Chemistry, 2018, vol. 79, p. 46 - 59
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 24 - 35
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1191 - 1196

3-Amino-1H-pyrazole-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Amino-1H-pyrazole-4-carboxamide manufacturers

Career Henan Chemical Co
Product
3-Amino-1H-pyrazole-4-carboxamide 5334-31-6
Price
US $9.80/KG
Min. Order
1g
Purity
≥99.0%
Supply Ability
100kg
Release date
2020-01-02

5334-31-6, 3-Amino-1H-pyrazole-4-carboxamideRelated Search:

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