ChemicalBook > CAS DataBase List > Cycloleucine

Cycloleucine

Product Name: Cycloleucine
CAS No.: 52-52-8
Chemical Name: Cycloleucine
Synonyms: x201;X 201;cb1639;CYCLEU;CB 1639;nsc1026;wr14997;NSC 1026;WR 14997;wr14,997
CBNumber: CB7376009
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 52-52-8.mol

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Cycloleucine Property

Melting point:: 320 °C (dec.) (lit.)
Boiling point:: 239.22°C (rough estimate)
Density: 1.1426 (rough estimate)
refractive index: 1.4827 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO: < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
pka: 2.38±0.20(Predicted)
form: Crystalline Flakes or Powder
color: White to beige
Water Solubility: 5 g/100 mL
Merck: 14,2734
BRN: 636626
CAS DataBase Reference: 52-52-8(CAS DataBase Reference)
NIST Chemistry Reference: Cyclopentanecarboxylic acid, 1-amino-(52-52-8)
EPA Substance Registry System: Cyclopentanecarboxylic acid, 1-amino- (52-52-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22
Safety Statements: 22-24/25
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: GY2625000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29224999
Hazardous Substances Data: 52-52-8(Hazardous Substances Data)
Toxicity: LD50 oral in rat: 290mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A48105
Product name: Cycloleucine
Purity: 97%
Packaging: 5g
Price: $209
Updated: 2025/07/31

Sigma-Aldrich

Product number: A48105
Product name: Cycloleucine
Purity: 97%
Packaging: 10g
Price: $303.73
Updated: 2025/07/31

TCI Chemical

Product number: A1063
Product name: 1-Aminocyclopentanecarboxylic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: A1063
Product name: 1-Aminocyclopentanecarboxylic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $102
Updated: 2025/07/31

TCI Chemical

Product number: A1063
Product name: 1-Aminocyclopentanecarboxylic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $306
Updated: 2025/07/31

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Cycloleucine Chemical Properties,Usage,Production

Chemical Properties

WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER

Uses

NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist

Uses

Cycloleucine can be used as a building block to synthesize:

Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction.
Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist.

Uses

Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies

Definition

ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

General Description

Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Purification Methods

Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]

Cycloleucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cycloleucine Suppliers

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View Lastest Price from Cycloleucine manufacturers

Henan Fengda Chemical Co., Ltd

Product: Cycloleucine 52-52-8
Price: US $30.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cycloleucine 52-52-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cycloleucine 52-52-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

52-52-8, CycloleucineRelated Search:

EC 2.6.1.2 Cyclopentane Bromocyclopentane 3-Aminophenol N-CARBOBENZOXY-DL-LEUCINE Glycine 6-Aminocaproic acid Acetaminophen Cyclopentanecarboxylic acid Cyclopentyl chloride ALTRENOGEST Methylcyclopentane Tris(hydroxymethyl)aminomethane 1-Aminocyclopentane-1-carboxylic acid methyl ester hydrochloride Cycloleucine Methyl Ester.HCl,CYCLOLEUCINE METHYL ESTER HCL BOC-CYCLOLEUCINE,N-ALPHA-T-BUTOXYCARBONYL-CYCLOLEUCINE,N-BOC-CYCLOLEUCINE FMOC-CYCLOLEUCINE,N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-CYCLOLEUCINE (1S,3R)-ACPD (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID

RARECHEM AK HD C019

TIMTEC-BB SBB004230

1-amino-cyclopentanecarboxylicaci

Amino-1-cyclopentanecarboxylic acid

CB 1639

cb1639

Cycloleucin

Cyclopentanecarboxylic Acid, 1-amino-, L-

Cyclopentanecarboxylic acid, L-amino

1-Aminocyclopentanecarboxylate

Cyclopentanecarboxylic acid, 1-amino-

1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID, 9 7%

1-Aminocyclopentane-3,3,4,4-D4-1-carboxylic Acid

Cycloleucine-carboxyl-13C, 2,2,5-D3

1-Aminocyclo-pentanecarboxylic acid Cycloleucine

1-AMINOCYCLOPENTANCARBOXYLICACID

Cycloleucine carboxylic acid

1-Amino-1-cyclopentanecarboxylicacid(Cycloleucine)

1-Carboxycyclopentylamine

1-Aminocyclopentanecarboxylic acid, 97+%

H-Cycloleu-OH

Cycloleucine,1-Aminocyclopentanecarboxylic acid

1-Amino-1-cyclopenta

Cyclolencine

NSC 112194

NSC 112195

NSC 112197

1-AMino-1-cyclopentanecarboxylic acid, 97% 5GR

l-cyclopentanecarboxylicaci

NSC 1026

nsc1026

WR 14,997

WR 14997

wr14,997

wr14997

X 201

x201

H-AC5C-OH

H-CLE-OH

H-NH(1)CPEN-OH

CYCLOLEUCINE

CYCLEU

1-AMINOCYCLOPENTANE-1-CARBOXYLIC ACID

1-AMINOCYCLOPENTANECARBOXYLIC ACID

1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID

1-AMINO-1-CARBOXYCYCLOPENTANE

Cycloleucine≥ 98% (HPLC)

Irbint-A02

1-Aminocyclopentanecarboxylic Acid &gt

Cycloleucine USP/EP/BP

Irbesartan Impurity 18

Irbesartan Impurity 37

TIANFU-CHEM - Cycloleucine

Ionotropic glutamate receptors,inhibit,glycine,NMDA,cytostatic,nucleic,Inhibitor,Cycloleucine,methylations,anxiolytic,transferase,iGluR,ATP

52-52-8

1G/瓶[52-52-8

1G/瓶52-52-8

H2NC5H8CO2H