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Folpet

Product Name
Folpet
CAS No.
133-07-3
Chemical Name
Folpet
Synonyms
folpe;Ftalan;Folpex;Folpel;folnit;ENOFOL;FOLPAN;FOLPET;FOLDAN;FALTAN
CBNumber
CB7377839
Molecular Formula
C9H4Cl3NO2S
Formula Weight
296.56
MOL File
133-07-3.mol
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Folpet Property

Melting point:
177-180°C
Boiling point:
333.8±52.0 °C(Predicted)
Density 
1.5097 (rough estimate)
vapor pressure 
2.1 x 10-5 Pa (25 °C)
refractive index 
1.6000 (estimate)
storage temp. 
0-6°C
pka
-3.34±0.20(Predicted)
form 
neat
color 
Crystals
Water Solubility 
practically insoluble
Merck 
13,4250
BRN 
193373
CAS DataBase Reference
133-07-3(CAS DataBase Reference)
NIST Chemistry Reference
Folpet(133-07-3)
EPA Substance Registry System
Folpet (133-07-3)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
20-36-40-43-50
Safety Statements 
36/37-46-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
TI5685000
HazardClass 
9
PackingGroup 
III
HS Code 
29309090
Hazardous Substances Data
133-07-3(Hazardous Substances Data)
Toxicity
LD50 orally in adult male, female rats: >5000 mg/kg (Gaines, Linder)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H332Harmful if inhaled

H351Suspected of causing cancer

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32057
Product name
Folpet
Purity
PESTANAL
Packaging
250mg
Price
$22.6
Updated
2021/03/22
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Folpet Chemical Properties,Usage,Production

Description

Folpet is practically insoluble in water. It is a protective leaf fungicide. Its mode of action inhibits normal cell division of a broad spectrum of microorganisms. It is used to control cherry leaf spot, rose mildew, rose black spot, and apple scab. It is used on berries, flowers, ornamentals, fruits, and vegetables and for seedand plant-bed treatment. It is also used as a fungicide in paints and plastics and for treatment of internal and external structural surfaces of buildings. It is incompatible with strongly alkaline preparations, such as lime sulphur.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Folpet is used to control downy mildews, powdery mildews, leaf spot diseases, scab and rots in fruit, ornamentals and vegetables.

Uses

Agricultural fungicide.

Uses

Folpet is a pesticide, fungicide agent from the thiophtalimide group. Occupational exposure occurs mostly in agricultural workers or in florists.

Definition

ChEBI: A member of the class of phthalimides that is phthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethylthio group. An agricultural fungicide, it has been used to control mildew, leaf spot, and other diseases in crops sice he 1950s.

General Description

White crystals. Used as a fungicide. Insoluble in water.

Air & Water Reactions

Insoluble in water. Hydrolyzed in alkaline solution. Hydrolysis products are corrosive to many metals.

Reactivity Profile

A halogenated phthalimide.

Contact allergens

Folpet is a pesticide, fungicide agent of thiophthalim ide group. Occupational exposure occurs mostly in agricultural workers or in florists. Photosensitivity has been reported.

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic and teratogenic data. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx. Used as a fungicide.

Carcinogenicity

An NCI bioassay of technicalgrade captan was conducted to determine carcinogenicity by administering captan in the feed to Osborne–Mendel rats and B6C3F1 mice. The major outcome was that tumors of the duodenum of B6C3F1 mice were associated with the captan treatment. There was no evidence that the tumors observed in Osborne–Mendel rats were treatment-related.
In the NCI study, groups of 50 rats of each sex were fed average doses of 2520 or 6050 ppm captan in the diet for 80 weeks. Groups of 50 mice of each sex were fed 8000 or 16,000 ppm captan in the diet for 80 weeks. These doses are approximately 250 (male) and 450 (female) mg/kg/day (high dose) and 50 (male) to 100 (female) mg/kg/day (low dose) in rats. In mice, these doses are approximately 2100 mg/kg/day (high dose) and 1000 mg/kg/day (low dose).

Metabolic pathway

Folpet contains an unstable trichloromethylthio (sulfenyl) moiety that has been shown to undergo rapid hydrolytic and metabolic degradation to phthalimide (2). By analogy with captan, presumably the trichloromethylthio moiety can be transferred to the sulfur atoms of thiols such as cysteine and glutathione. Thus in the presence of thiols such as glutathione, folpet is probably cleaved at the N-S bond to form thiophosgene (3) and other gaseous products such as hydrogen sulfide, hydrogen chloride and carbonyl sulfide. Thiophosgene (3) is rapidly hydrolysed by water. The trichloromethylthio group and thiophosgene are believed to be intermediates in the formation of thiazolidine-2-thione-4-carboxylica cid (4) which is an addition product with cysteine. A thiazolidine derivative of glutathione may also be formed (5). Folpet is metabolised in plants and animals to phthalimide (2) and further to phthalamic acid (6) and phthalic acid (7) (see Scheme 1).

Degradation

Folpet is hydrolysed rapidly in strongly alkaline conditions (PM). The hydrolytic DT50 of folpet is 1.1 hours at pH 7. The half-life for hydrolysis of folpet in a commercial formulation was 12 hours at pH 7.35. Folpet was decomposed in dilute, aqueous sulfuric acid with a half-life 10.5 hours at pH 3. The products were mainly phthalimide (2) and small amounts of phthalamic acid (6) and phthalic acid (7). Phthalamic acid (6) had completely degraded by the time all of the folpet had decomposed (Cabras et al., 1997).
Folpet reacts with thiols in two steps. Firstly, phthalimide (2), thiophosgene (3), hydrochloric acid and the corresponding disulfide are produced. Secondly, depending on the thiol, thiophosgene (3) can react with any remaining thiols to give trithiocarbonates, thiurams, etc. In some cases as, for example, with L-cysteine, thiophosgene (3) combines with amino and thiol groups of the reactant yielding the cyclic 2- thiazolidinethiones (4) (Davidek and Seifert, 1975). Folpet reacts with reduced glutathione (GSH) to produce mainly oxidised glutathione (GSSG). Five unidentified products contained all or a portion of the trichloromethyl moiety. Gaseous products including carbonyl sulfide were released (Siegel, 1970).

Folpet Preparation Products And Raw materials

Raw materials

Preparation Products

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Folpet Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
kennyrong@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
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57
China Langchem Inc.
Tel
0086-21-58956006,021-38701807;021-58950017
Fax
0086-21-58956100
Email
sales@langchem.com
Country
China
ProdList
7833
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Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
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Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001;021-33690831-8001
Fax
021-33690831
Email
postmaster@tyjchem.cn;1094628792@qq.com
Country
China
ProdList
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Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
028-85911938-
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9750
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9914
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58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
021-50430803
Fax
qq:1849315414
Email
lyh_antaeus@163.com;1849315414@qq.com
Country
China
ProdList
9642
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View Lastest Price from Folpet manufacturers

Longyan Tianhua Biological Technology Co., Ltd
Product
Folpet 133-07-3
Price
US $25.00/Kg/Bag
Min. Order
10Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-10-29
career henan chemical co
Product
Folpet 133-07-3
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-20
Zhenfei Industrial Co. Ltd.
Product
Folpet 133-07-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000kg
Release date
2018-11-21

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