ChemicalBook > CAS DataBase List > 4-(Bromoacetyl)pyridine hydrobromide

4-(Bromoacetyl)pyridine hydrobromide

Product Name
4-(Bromoacetyl)pyridine hydrobromide
CAS No.
5349-17-7
Chemical Name
4-(Bromoacetyl)pyridine hydrobromide
Synonyms
BUTTPARK 37\12-45;4-( Bromoacetyl)pyridine;4-BromoAcetyl Pyridine HBr;4-(2-BroMo-acetyl)-pyridiniuM;4-(BROMOACETYL)PYRIDINE HYDROBROMIDE;2-broMo-1-(pyridin-4-yl)ethanone.HBr;4-(2-BROMO-ACETYL)-PYRIDINIUM, BROMIDE;4-(2-Bromoacetyl)pyridine hydrobromide;2-Bromo-1-(4-pyridinyl)-1-ethanone*HBr;4-(Bromoacetyl)pyridinehydrobromide,98%
CBNumber
CB7395811
Molecular Formula
C7H7Br2NO
Formula Weight
280.94
MOL File
5349-17-7.mol
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4-(Bromoacetyl)pyridine hydrobromide Property

Melting point:
194 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder
color 
Off-white
Water Solubility 
Soluble in water.
CAS DataBase Reference
5349-17-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-37/39
Hazard Note 
Irritant
HazardClass 
8
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B679138
Product name
4-(Bromoacetyl)pyridineHydrobromide
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR23066
Product name
4-(Bromoacetyl)pyridinehydrobromide
Packaging
5g
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-9-W6
Product name
4-(Bromoacetyl)pyridine hydrobromide
Packaging
5G
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB36056
Product name
2-Bromo-1-(pyridin-4-yl)ethan-1-one hydrobromide
Packaging
2g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
U851
Product name
4-(Bromoacetyl)pyridinehydrobromide
Packaging
5g
Price
$61
Updated
2021/12/16
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4-(Bromoacetyl)pyridine hydrobromide Chemical Properties,Usage,Production

Uses

Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase 4-(Bromoacetyl)pyridine hydrobromide was used to prepare 2-Phenyl-4-(4-pyridyl)imidazole.

Synthesis

1122-54-9

5349-17-7

General procedure for the synthesis of 4-(bromoacetyl)pyridine hydrobromide from 4-acetylpyridine: 558 g of batch master batch was added to a reaction flask, followed by the addition of 42 g of ethyl acetate, and 121.1 g of 4-acetylpyridine was added slowly with stirring, keeping the reaction temperature at 20~30 °C and stirring well. N-bromosuccinimide (NBS) 186.9 g was added in batches, followed by slow warming to 65~75 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock was fully reacted. After completion of the reaction, the reaction mixture was cooled to 0~10°C to allow complete crystallization of the product. The crystals were collected by filtration, washed and pulped with 650 g of deionized water, filtered again, and dried to give 275.6 g of 4-(bromoacetyl)pyridine hydrobromide as a white solid in 98.1% molar yield.

References

[1] Patent: WO2005/73225, 2005, A1. Location in patent: Page/Page column 49-50
[2] Patent: CN106632001, 2017, A. Location in patent: Paragraph 0026; 0027; 0028; 0029
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 787 - 797
[4] Patent: WO2009/158393, 2009, A1. Location in patent: Page/Page column 51
[5] Patent: US2007/142415, 2007, A1. Location in patent: Page/Page column 17

4-(Bromoacetyl)pyridine hydrobromide Preparation Products And Raw materials

Raw materials

4-Acetylpyridine Hydrogen bromide Bromine Acetic acid

Preparation Products

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View Lastest Price from 4-(Bromoacetyl)pyridine hydrobromide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-(Bromoacetyl)pyridine hydrobromide 5349-17-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-05
Dideu Industries Group Limited
Product
4-(Bromoacetyl)pyridine hydrobromide 5349-17-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26
Career Henan Chemical Co
Product
4-(Bromoacetyl)pyridine hydrobromide 5349-17-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-01-02

5349-17-7, 4-(Bromoacetyl)pyridine hydrobromideRelated Search:

Pyridine 2,6-Diacetylpyridine L-PICEIN 3-Acetylpyridine 4-Acetylpyridine Pyridine hydrobromide 2-Acetylpyridine Pyridinium tribromide Scopolamine hydrobromide Pyridine hydrochloride 1-Hexadecylpyridinium bromide pyridinium Chlorochromate Bromine 2-(BROMOACETYL)PYRIDINE HYDROBROMIDE,2-(2-BROMOACETYL)PYRIDINE HYDROBROMIDE 3-(BROMOACETYL)PYRIDINE HYDROBROMIDE,3-(2-Bromoacetyl)-pyridine hydrobromide 2-BROMO-1-PYRIDIN-4-YLETHANONE 4-(2-BROMOETHYL)-PYRIDINE 4-(Bromoacetyl)pyridine hydrobromide

  • BUTTPARK 37\12-45
  • 2-BROMO-1-PYRDIN-4-YLETHAN-1-ONE HYDROBROMIDE
  • 2-BROMO-1-(4-PYRIDINYL)-1-ETHANONE HYDROBROMIDE
  • 4-(BROMOACETYL)PYRIDINE HYDROBROMIDE
  • 4-(2-BROMO-ACETYL)-PYRIDINIUM, BROMIDE
  • 2-Bromo-1-pyridin-4-ylethanone hydrobromide
  • 2-Bromo-1-pyrdin-3-ylethan-1-one hydrobromide
  • 2-Bromo-1-(pyridin-4-yl)ethan-1-one hydrobromide
  • 4-( Bromoacetyl)pyridine
  • ETHANONE,2-BROMO-1-(4-PYRIDINYL)-,HYDROBROMIDE
  • 1-(2-bromo-4-pyridinyl)ethanone hydrobromide
  • 4-(2-Bromoacetyl)pyridine hydrobromide
  • JR-14042, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, 96%
  • 2-BroMo-1-pyridin-4-yl-ethanone hydrobroMic acid
  • 2-broMo-1-(4-pyridinyl)-ethanone, hydrobroMide
  • 4-(2-BroMo-acetyl)-pyridiniuM
  • 2-Bromo-1-(pyridin-4-yl)ethan-1-one hydrobromide, 4-(2-Bromethanoyl)pyridine hydrobromide
  • 2-broMo-1-(pyridin-4-yl)ethanone.HBr
  • 2-Bromo-1-(4-chloro-pyridin-2-yl)-ethanone hydrobromide
  • 2-Bromo-1-(4-pyridinyl)-1-ethanone*HBr
  • 4-(Bromoacetyl)pyridinehydrobromide,98%
  • 4-(Bromoacetyl)pyridine hydrobromide ISO 9001：2015 REACH
  • 4-BromoAcetyl Pyridine HBr
  • 5349-17-7
  • Heterocyclic Compounds
  • Acetyl Halides
  • Pyridines
  • CHIRAL CHEMICALS
  • Acetyl Halides