4-(Bromoacetyl)pyridine hydrobromide
- Product Name
- 4-(Bromoacetyl)pyridine hydrobromide
- CAS No.
- 5349-17-7
- Chemical Name
- 4-(Bromoacetyl)pyridine hydrobromide
- Synonyms
- BUTTPARK 37\12-45;4-( Bromoacetyl)pyridine;4-BromoAcetyl Pyridine HBr;4-(2-BroMo-acetyl)-pyridiniuM;4-(BROMOACETYL)PYRIDINE HYDROBROMIDE;2-broMo-1-(pyridin-4-yl)ethanone.HBr;4-(2-BROMO-ACETYL)-PYRIDINIUM, BROMIDE;4-(2-Bromoacetyl)pyridine hydrobromide;2-Bromo-1-(4-pyridinyl)-1-ethanone*HBr;4-(Bromoacetyl)pyridinehydrobromide,98%
- CBNumber
- CB7395811
- Molecular Formula
- C7H7Br2NO
- Formula Weight
- 280.94
- MOL File
- 5349-17-7.mol
4-(Bromoacetyl)pyridine hydrobromide Property
- Melting point:
- 194 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- color
- Off-white
- Water Solubility
- Soluble in water.
- CAS DataBase Reference
- 5349-17-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-37/39
- Hazard Note
- Irritant
- HazardClass
- 8
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B679138
- Product name
- 4-(Bromoacetyl)pyridineHydrobromide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR23066
- Product name
- 4-(Bromoacetyl)pyridinehydrobromide
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H56-9-W6
- Product name
- 4-(Bromoacetyl)pyridine hydrobromide
- Packaging
- 5G
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB36056
- Product name
- 2-Bromo-1-(pyridin-4-yl)ethan-1-one hydrobromide
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- U851
- Product name
- 4-(Bromoacetyl)pyridinehydrobromide
- Packaging
- 5g
- Price
- $61
- Updated
- 2021/12/16
4-(Bromoacetyl)pyridine hydrobromide Chemical Properties,Usage,Production
Uses
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase 4-(Bromoacetyl)pyridine hydrobromide was used to prepare 2-Phenyl-4-(4-pyridyl)imidazole.
Synthesis
1122-54-9
5349-17-7
General procedure for the synthesis of 4-(bromoacetyl)pyridine hydrobromide from 4-acetylpyridine: 558 g of batch master batch was added to a reaction flask, followed by the addition of 42 g of ethyl acetate, and 121.1 g of 4-acetylpyridine was added slowly with stirring, keeping the reaction temperature at 20~30 °C and stirring well. N-bromosuccinimide (NBS) 186.9 g was added in batches, followed by slow warming to 65~75 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock was fully reacted. After completion of the reaction, the reaction mixture was cooled to 0~10°C to allow complete crystallization of the product. The crystals were collected by filtration, washed and pulped with 650 g of deionized water, filtered again, and dried to give 275.6 g of 4-(bromoacetyl)pyridine hydrobromide as a white solid in 98.1% molar yield.
References
[1] Patent: WO2005/73225, 2005, A1. Location in patent: Page/Page column 49-50
[2] Patent: CN106632001, 2017, A. Location in patent: Paragraph 0026; 0027; 0028; 0029
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 787 - 797
[4] Patent: WO2009/158393, 2009, A1. Location in patent: Page/Page column 51
[5] Patent: US2007/142415, 2007, A1. Location in patent: Page/Page column 17
4-(Bromoacetyl)pyridine hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Bromoacetyl)pyridine hydrobromide manufacturers
- Product
- 4-(Bromoacetyl)pyridine hydrobromide 5349-17-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-05
- Product
- 4-(Bromoacetyl)pyridine hydrobromide 5349-17-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 4-(Bromoacetyl)pyridine hydrobromide 5349-17-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02