MILNACIPRAN HYDROCHLORIDE

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MILNACIPRAN HYDROCHLORIDE

Product Name: MILNACIPRAN HYDROCHLORIDE
CAS No.: 92623-85-3
Chemical Name: MILNACIPRAN HYDROCHLORIDE
Synonyms: IXEL;TN-912;F 2207;Milborn;Milnace;TOLEDOMIN;MILNACIPRAN;MIDALCIPRAN;Minapulen D10;MILNACIPRAN HCL
CBNumber: CB7423244
Molecular Formula: C15H22N2O
Formula Weight: 246.35
MOL File: 92623-85-3.mol

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MILNACIPRAN HYDROCHLORIDE Property

Boiling point:: 393.0±21.0 °C(Predicted)
Density: 1.077±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H₂O: 19 mg/mL
form: solid
pka: 10.36±0.29(Predicted)
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: GZ1014010

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1184
Product name: Milnacipran
Packaging: 10mg
Price: $50
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006939
Product name: MILNACIPRAN-D10
Purity: 95.00%
Packaging: 5MG
Price: $498.97
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134308
Product name: Milnacipran HCl
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134308
Product name: Milnacipran HCl
Purity: >99%
Packaging: 250mg
Price: $765
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134308
Product name: Milnacipran HCl
Purity: >99%
Packaging: 1g
Price: $1504.5
Updated: 2021/12/16

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MILNACIPRAN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Ixel was launched in France as an antidepressant. There are several synthetic routes, the shortest of which is five steps using benzyl cyanide as the starting material. It is a specific serotonin and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action makes it superior to selective serotonin reuptake inhibitors (SSRI) like fluoxetine and fluvoxamine. Ixel has no significant effect on postsynaptic receptors, very limited effect on cardiac function, and no quinidine-like arrhythmal effects. It has a good side effect profile with lower incidence of anticholinergic-like side effects, less sedation due to histamine H₁-receptor binding, and a lack of α₁- adrenoceptor antagonism. Ixel has a short half-life (7 hr) with no active metabolites. It is not metabolized by CYP450 therefore drug interaction is unlikely. It is superior in the treatment of serious depression with no need to titrate drug dose.

Originator

Pierre Fabre (France)

Definition

ChEBI: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide is a member of acetamides.

brand name

Ixel

Mechanism of action

Milnacipran selectively inhibits the reuptake of 5-HT (selectivity ratio, 9) at the presynaptic membrane site, thus increasing the concentration of 5-HT in the synaptic cleft. Although milnacipran is not a TCA, its mechanism of action is similar to that of imipramine, and its binding and reuptake inhibition profile more closely resembles that of the TCAs. Milnacipran has weak affinity for adrenergic, muscarinic, and H1 receptors and, therefore, is expected to be devoid of the prominent side effects observed for the TCAs. In clinical studies, milnacipran showed antidepressant efficacy similar to that of TCAs and SSRIs.

Pharmacokinetics

In humans, milnacipran distinguishes itself from many other antidepressants by its simple pharmacokinetics. It is rapidly absorbed, with a high oral bioavailability, and it exhibits linear pharmacokinetics over a dose range of 25 to 200 mg/day. It circulates in the blood and distributes in the body principally as unmetabolized drug. Steady-state plasma levels are reached within 32 to 48 hours after twice-daily oral administration, and its metabolism does not involve the CYP enzyme system. Approximately 50% of the dose is excreted in urine as unmetabolized drug, and another 14% is excreted as its N-glucuronide conjugate. The remaining eliminated drug is composed of conjugated Phase I inactive metabolites. Because the unmetabolized drug is the only compound responsible for the activity of milnacipran, no dosage adjustment is needed in patients presenting liver impairment.

Clinical Use

(±)-Milnacipran is the ci s-aminomethyl derivative of phenylcyclopropanecarboxamide that acts by inhibiting both NE and 5-HT reuptake. It is structurally different from the other NSRIs and currently is only available in Europe as a racemic mixture, with both enantiomers exhibiting antidepressant activity. Substituting the aminomethyl group of milnacipran with an aminopropyl gives a milnacipran homologue that exhibits antidepressant activity as a potent N-methyl-D-aspartate (NMDA) receptor antagonist. A glutamate hypothesis is being investigated as an alternative mechanism of depression.

Side effects

Milnacipran has proven to be a very safe drug, with an adverse-event profile clearly superior to that of TCAs and, to a certain extent, that of SSRIs. Only approximately 10% of patients experience side effects, and only dysuria occurred more frequently (2%) with milnacipran than with TCAs or SSRIs. Milnacipran therefore appears to be an antidepressant with a very favorable benefit:risk ratio, although with a slower onset of action than the TCAs.

MILNACIPRAN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MILNACIPRAN HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: (-)-Milnacipran 92623-85-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

92623-85-3, MILNACIPRAN HYDROCHLORIDERelated Search:

Levomilnacipran Aniline hydrochloride Trimethylamine hydrochloride Betaine hydrochloride Methylamine hydrochloride Dimethylamine hydrochloride Imipramine hydrochloride Maprotiline ILOPERIDONE Famciclovir Blonanserin AGOMELATINE (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl-N,N-diethyl-1-phenylcyclopropanecarboxamide MILNACIPRAN HYDROCHLORIDE RAC CIS MILNACIPRAN-D10, HYDROCHLORIDE cyclopropyl(phenyl)methanamine 1-Phenylcyclopropane-1-carbaldehyde

(1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIMETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE

IXEL

F 2207

(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

2β-(Aminomethyl)-N,N-diethyl-1-phenyl-1β-cyclopropanecarboxamide

2β-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1β-carboxamide

(1S,2R)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

(±)-cis-2-Aminomethyl-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

rac-(1S*,2R*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

TN-912

MILNACIPRAN HYDROCHL

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

Milborn

Milnace

CyclopropanecarboxaMide,2-(aMinoMethyl)-N,N-diethyl-1-phenyl-, (1R,2S)-rel-

MILNACIPRAN

MILNACIPRAN HCL

MIDALCIPRAN

MIDALCIPRAN HYDROCHLORIDE

TOLEDOMIN

Milnacipran-d10

Milnacipran Impurity A

Mina F Leon hydrochloride

Milnacipran (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Minapulen D10

92623-85-3

C15H22N2O.HCl

Other APIs