N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Product Name: N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
CAS No.: 16357-59-8
Chemical Name: N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Synonyms: EEDQ;2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE;ethyl 2-ethoxyquinoline-1(2H)-carboxylate;ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate;2-Ethoxy-2H-quinoline-1-carboxylic acid ethyl ester;EEDQ extrapure;2-Ethoxy-1-ethoxycar;LABOTEST-BB LT00440890;EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2;ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA
CBNumber: CB7436031
Molecular Formula: C14H17NO3
Formula Weight: 247.29
MOL File: 16357-59-8.mol

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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Property

Melting point:: 62-67 °C(lit.)
Boiling point:: 125-128 °C (0.1 mmHg)
Density: 1.1173 (rough estimate)
refractive index: 1.5300 (estimate)
Flash point:: 125-128°C/0.1mm
storage temp.: 2-8°C
solubility: Chlorofrom (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: -1.27±0.40(Predicted)
form: Crystalline Powder
color: White to beige
Water Solubility: insoluble
Sensitive: Moisture Sensitive
Merck: 14,3518
BRN: 533048
CAS DataBase Reference: 16357-59-8(CAS DataBase Reference)
EPA Substance Registry System: 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester (16357-59-8)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 38-36/37/38-20/21/22
Safety Statements: 22-24/25-36/37/39-26-36
WGK Germany: 3
RTECS: VB2010000
F: 9-21
TSCA: Yes
HS Code: 29334990
Toxicity: mouse,LD50,intraperitoneal,32mg/kg (32mg/kg),Journal of Medicinal Chemistry. Vol. 14, Pg. 49, 1971.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 149837
Product name: 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
Purity: ≥99%
Packaging: 5g
Price: $21.84
Updated: 2024/03/01

Sigma-Aldrich

Product number: 149837
Product name: 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
Purity: ≥99%
Packaging: 25g
Price: $70.6
Updated: 2024/03/01

TCI Chemical

Product number: E0363
Product name: 1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $29
Updated: 2024/03/01

Alfa Aesar

Product number: A13724
Product name: 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%
Packaging: 10g
Price: $32.2
Updated: 2024/03/01

Alfa Aesar

Product number: A13724
Product name: 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%
Packaging: 50g
Price: $90.65
Updated: 2024/03/01

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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow solid

Uses

Peptide condensing agent with little or no racemization. Amidation coupling reagent.

Uses

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is an irreversible membrane-bound receptor antagonist. It is used in synthetic chemistry, discovery, process R&D. It also acts as coupling reagents.

Uses

In the synthesis of peptides.

Purification Methods

Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.]

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Preparation Products And Raw materials

Raw materials

Quinoline N,N-Dimethylformamide Potassium hydroxide Ethyl chloroformate Boron trifluoride diethyl etherate Diethyl ether Dichloromethane Magnesium sulfate

Preparation Products

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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Suppliers

Americas 1 Austria 1 Belgium 3 China 247 Europe 3 Germany 8 India 13 Japan 12 South Korea 1 Switzerland 4 The Netherlands 1 United Kingdom 16 United States 50 Global 360

Suzhou Highfine Biotech Co., Ltd

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View Lastest Price from N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2022-11-10

Henan Aochuang Chemical Co.,Ltd.

Product: N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

16357-59-8, N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinolineRelated Search:

DIETHOXYMETHANE Ethanol Ethoxyquin Ethyl acetate Ethoxyamine hydrochloride Ethylparaben Ethyl acrylate Ethyl pyruvate Ethyl formate ISOXADIFEN-ETHYL N-PHENYLCARBAMIC ACID METHYL ESTER N-METHYL-N-PHENYLURETHANE ethyl dimethylcarbamate Isobutyl 1,2-dihydro-2-isobutoxy-1-quinoline-carboxylate N,N,2-Trimethylbenzenamine PHENYLURETHANE N-Methylformanilide ethyl (hydroxymethyl)-carbamate

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline≥ 99% (HPLC)

Ethyl 2-ethoxy-1,2-dihydro-1-quinolinecarboxylate for synthesis

EEDQ~N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline ,98%

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 99+% 100GR

ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA

ethyl 2-ethoxyquinoline-1(2H)-carboxylate

2-Ethoxy-1-ethoxycarbonyl-1.2-dihydroquinoline 1g [16357-59-8]

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline,N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, EEDQ, Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate

EEDQ, 97+% (2-ETHOXY-1-ETHOXYCARBONYL-1, 2-DIHYDROQUINOLINE)

2-Ethoxy-1-ethoxycar

2-Ethoxy-2H-quinoline-1-carboxylic acid ethyl ester

ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline >=99%

- ethoxy - 1-2 ethoxy carbonyl - 1, 2 - dihydro quinoline

2-ethoxy-1(2h)-quinolinecarboxylicaciethylester

1,2-Dihydro-2-ethoxy-1-(ethoxycarbonyl)quinoline, Ethyl 2-ethoxyquinoline-1(2H)-carboxylate, EEDQ

Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate 97+%

EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2

EEDQ, 99+%, (2-ETHOXY-1-ETHOXYCARBONYL-1 ,2-DIHYDROQUINOLINE)

N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE 99% ( EEDQ)

Eedq(2-Ethoxy-1-Ethoxycarbonyl-1,2-Dihydroquinoline)

1,2-Dihydro-2-ethoxy-1-quinolinecarboxylicacidester

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 99+%

1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester

ethoxycarbonyl-2-ethoxy-1-2-dlhdroquinoline

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ)

EEDQ extrapure

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, EEDQ, Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate

Ethyl 2-ethoxy-1(2H)-quinolinecarboxylate

Ethyl 2-ethoxy-2H-quinoline-1-carboxylate

N-Carbethoxy-2-ethoxy-1,2-dihydroquinoline

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline ,98.3%

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline（EEDQ）

1,2-Dihydro-2-ethoxy-1-quinolinecarboxylic acid ethyl ester

LABOTEST-BB LT00440890

ETHYL 1,2-DIHYDRO-2-ETHOXY-1-QUINOLINECARBOXYLATE

ETHYL 1,2-DIHYDRO-2-ETHOXYQUINOLINE-1-CARBOXYLATE

ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECARBOXYLATE

EEDQ

2-ETHOXY-1(2H)-QUINOLINECARBOXYLIC ACID ETHYL ESTER

2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECARBOXYLIC ACID ETHYL ESTER

2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE

1-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE

2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline

EEDQ, 99+%, (2-ETHOXY-1-ETHOXYCARBONYL-1 ,2-DIHYDROQUINO

N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE

1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline&gt

EEDQ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline,99%

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline USP/EP/BP

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8

16357-59-8

C11H17ON3

Condensation & Active Esterification

Coupling Reactions (Peptide Synthesis)

Peptide Synthesis

Others