ChemicalBook > CAS DataBase List > N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- Product Name
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- CAS No.
- 16357-59-8
- Chemical Name
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- Synonyms
- EEDQ;2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE;ethyl 2-ethoxyquinoline-1(2H)-carboxylate;ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate;2-Ethoxy-2H-quinoline-1-carboxylic acid ethyl ester;EEDQ extrapure;2-Ethoxy-1-ethoxycar;LABOTEST-BB LT00440890;EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2;ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA
- CBNumber
- CB7436031
- Molecular Formula
- C14H17NO3
- Formula Weight
- 247.29
- MOL File
- 16357-59-8.mol
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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Property
- Melting point:
- 62-67 °C(lit.)
- Boiling point:
- 125-128 °C (0.1 mmHg)
- Density
- 1.1173 (rough estimate)
- refractive index
- 1.5300 (estimate)
- Flash point:
- 125-128°C/0.1mm
- storage temp.
- 2-8°C
- solubility
- Chlorofrom (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- -1.27±0.40(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- Water Solubility
- insoluble
- Sensitive
- Moisture Sensitive
- Merck
- 14,3518
- BRN
- 533048
- CAS DataBase Reference
- 16357-59-8(CAS DataBase Reference)
- EPA Substance Registry System
- 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester (16357-59-8)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 38-36/37/38-20/21/22
- Safety Statements
- 22-24/25-36/37/39-26-36
- WGK Germany
- 3
- RTECS
- VB2010000
- F
- 9-21
- TSCA
- Yes
- HS Code
- 29334990
- Toxicity
- mouse,LD50,intraperitoneal,32mg/kg (32mg/kg),Journal of Medicinal Chemistry. Vol. 14, Pg. 49, 1971.
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 149837
- Product name
- 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $21.84
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 149837
- Product name
- 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
- Purity
- ≥99%
- Packaging
- 25g
- Price
- $70.6
- Updated
- 2024/03/01
TCI Chemical
- Product number
- E0363
- Product name
- 1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $29
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A13724
- Product name
- 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%
- Packaging
- 10g
- Price
- $32.2
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A13724
- Product name
- 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%
- Packaging
- 50g
- Price
- $90.65
- Updated
- 2024/03/01
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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow solid
Uses
Peptide condensing agent with little or no racemization. Amidation coupling reagent.
Uses
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is an irreversible membrane-bound receptor antagonist. It is used in synthetic chemistry, discovery, process R&D. It also acts as coupling reagents.
Uses
In the synthesis of peptides.
Purification Methods
Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.]
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Preparation Products And Raw materials
Raw materials
Quinoline
N,N-Dimethylformamide
Potassium hydroxide
Ethyl chloroformate
Boron trifluoride diethyl etherate
Diethyl ether
Dichloromethane
Magnesium sulfate
Preparation Products
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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Suppliers
- Tel
- --
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- --
- fo@acros.com
- Country
- Belgium
- ProdList
- 3824
- Advantage
- 58
- Tel
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- nfo@alkemi.be
- Country
- Belgium
- ProdList
- 2201
- Advantage
- 58
- Tel
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- Fax
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- info@acros.com
- Country
- Belgium
- ProdList
- 6772
- Advantage
- 81
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View Lastest Price from N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-11-10
Watson Biotechnology Co.,Ltd
- Product
- EEDQ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline 16357-59-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-08-22
Henan Aochuang Chemical Co.,Ltd.
- Product
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-26
16357-59-8, N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinolineRelated Search:
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