ACETYLSALICYLIC ANHYDRIDE

Product Name: ACETYLSALICYLIC ANHYDRIDE
CAS No.: 1466-82-6
Chemical Name: ACETYLSALICYLIC ANHYDRIDE
Synonyms: Aspirin IMpurity F;2-(Acetyloxy)benzoic anhydride;Vigal;pircan;contraflu;NSC 63848;NSC 80056;aspirinanhydride;Aspirin Impurity 6;Aspirin EP Impurity F
CBNumber: CB7439577
Molecular Formula: C18H14O7
Formula Weight: 342.3
MOL File: 1466-82-6.mol

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ACETYLSALICYLIC ANHYDRIDE Property

Melting point:: 80-83 °C
Boiling point:: 511.2±35.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
BRN: 2015320
InChI: InChI=1S/C18H14O7/c1-11(19)23-15-9-5-3-7-13(15)17(21)25-18(22)14-8-4-6-10-16(14)24-12(2)20/h3-10H,1-2H3
InChIKey: OAWXYINGQXLWOE-UHFFFAOYSA-N
SMILES: C(=O)(OC(=O)C1C=CC=CC=1OC(C)=O)C1C=CC=CC=1OC(C)=O

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
RTECS: VO0710000
F: 10-21

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1942
Product name: Acetylsalicylic Anhydride (Aspirin Impurity F)
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging: 50mg
Price: $697.3
Updated: 2025/07/31

TRC

Product number: A187785
Product name: AcetylsalicylicAnhydride
Packaging: 10mg
Price: $85
Updated: 2021/12/16

TRC

Product number: A187785
Product name: AcetylsalicylicAnhydride
Packaging: 25mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: 7270AA
Product name: 2-Acetoxybenzoicanhydride
Packaging: 100mg
Price: $91
Updated: 2021/12/16

AK Scientific

Product number: 7270AA
Product name: 2-Acetoxybenzoicanhydride
Packaging: 250mg
Price: $107
Updated: 2021/12/16

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ACETYLSALICYLIC ANHYDRIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Acetylsalicylic Acid Impurity D

Uses

Acetylsalicylic Acid (A187780) Impurity D.

Synthesis

50-78-2

1466-82-6

General procedure for the synthesis of 2-(acetyloxy)benzoic anhydride from acetylsalicylic acid: 1. prepare a suspension of 2-acetoxybenzoic acid (5.0 g, 28 mmol) in 30 mL of dichloromethane. 2. a solution of N,N'-dicyclohexylcarbodiimide (DCC, 2.9 g, 13.9 mmol) in 10 mL of dichloromethane was added to the above suspension. 3. The reaction mixture was stirred at room temperature overnight. 4. After completion of the reaction, the by-product dicyclohexylurea (DCU) was filtered through a glass filter and washed with a small amount of dichloromethane. 5. The solvent was evaporated and the resulting residue was dissolved in ethyl acetate. 6. The resulting suspension was filtered through a glass filter to remove residual DCU. 7. The filtrate was evaporated to give 2-(acetyloxy)benzoic anhydride as a clear thick oil, which solidified after storage at -20 °C. Yield: 4.6 g (quantitative). 1H NMR (CDCl3, 400 MHz): δ 8.08 (d, 2H, J = 7.9 Hz), 7.70 (t, 2H, J = 7.8 Hz), 7.40 (t, 2H, J = 7.7 Hz), 7.19 (d, 2H, J = 8.1 Hz), 2.31 (s, 6H). 13C NMR (CDCl3, 100 MHz): δ 169.42, 159.29, 151.83, 135.54, 132.24, 126.29, 124.42, 121.69, 20.89. IR (KBr) νmax (cm-1): 3570 (w), 3491 (w), 3445 (w), 3332 (br), 3205 (w), 3100 (s, CH), 2932 (s, CH), 2855 (w), 2409 (w), 2032 (w), 1789 (br, C=O), 1728 (br, C=O) , 1603 (s, C=C), 1581 (s), 1484 (s), 1451 (s), 1369 (s), 916 (s), 506 (s). HRMS m/z Calcd. for C18H14Na7O6: (M + Na)+ 365.0637. Found: 365.0638. Melting point: 80-85°C.

References

[1] Patent: WO2015/89389, 2015, A1. Location in patent: Paragraph 0098
[2] Tetrahedron Letters, 2016, vol. 57, # 3, p. 325 - 328
[3] Synthetic Communications, 2001, vol. 31, # 3, p. 395 - 399
[4] Chemische Berichte, 1910, vol. 43, p. 2990
[5] Chem. Zentralbl., 1911, vol. 82, # I, p. 1568

ACETYLSALICYLIC ANHYDRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ACETYLSALICYLIC ANHYDRIDE Suppliers

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View Lastest Price from ACETYLSALICYLIC ANHYDRIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: ACETYLSALICYLIC ANHYDRIDE 1466-82-6
Price: US $4656.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-07-25

1466-82-6, ACETYLSALICYLIC ANHYDRIDERelated Search:

Acetylsalicylic acid Sasapyrine 4-Hydroxybenzoic acid ACETYLSALICYLSALICYLIC ACID 3-Hydroxybenzoic acid 4-amino-6-hydroxybenzene-1,3-dicarboxylic acid 2-Ethoxybenzoic acid Methyl salicylate 2-ETHOXYBENZYL ALCOHOL Benzyl benzoate Methyl 2-methoxybenzoate Ethyl 2-ethoxybenzoate 2-Methoxybenzoic acid ethyl ester Benzyl salicylate ACETYLSALICYLIC ACID METHYL ESTER ACETYLSALICYLIC ANHYDRIDE Ethyl 2-hydroxybenzoate 2-Ethoxybenzaldehyde

O-ACETYLSALICYLIC ANHYDRIDE

2-(acetyloxy)-benzoicacianhydride

2-(acetyloxy)benzoicacidanhydride

acetylsalicylicacidanhydride

aspirinanhydride

contraflu

pircan

salicylicacid,acetate,anhydride

2-acetoxybenzoic anhydride

ACETYLSALICYLIC ANHYDRIDE

ACETYLSALISYLIC ACID IMP F

ACETYLSALICYLIC ACID IMPURITY F

2-(Acetyloxy)benzoic Acid 1,1'-Anhydride

NSC 63848

NSC 80056

Vigal

Bis(2-acetoxybenzoic acid)anhydride

Bis(2-acetyloxybenzoic)anhydride

(2-acetyloxybenzoyl) 2-acetyloxybenzoate

(2-acetyloxyphenyl)carbonyl 2-acetyloxybenzoate

2-acetoxybenzoic acid (2-acetoxybenzoyl) ester

Benzoic acid, 2-(acetyloxy)-, 1,1'-anhydride

Aspirin IMpurity F

(Acetysalicyclclic anhydride)

Acetylsalicylic Acid IMpurity F (Aspirin IMpurity F)

Aspirin EP Impurity F

Acetylsalicylic Anhydride (Aspirin Impurity F)

Aspirin Impurity 6

Acetylsalicylic Anhydride (Aspirin Impurity F) solution

2-acetyloxybenzoic acid [(2-acetyloxyphenyl)-oxomethyl] ester

Acetylsalicylic Acid Impurity 6（Acetylsalicylic Acid EP Impurity F）

Acetylsalicylic Acid EP Impurity F

2-(Acetyloxy)benzoic Anhydride (Ace

Acetylsalicylic Acid EP Impurity F (Aspirin Impurity F)

Carbasalate EP Impurity A

2-(Acetyloxy)benzoic anhydride

Acetylsalicylic Acid EP Impurity F (Acetylsalicylic Anhydride)

Aspirin Impurity FQ: What is Aspirin Impurity F Q: What is the CAS Number of Aspirin Impurity F Q: What is the storage condition of Aspirin Impurity F Q: What are the applications of Aspirin Impurity F

Aspirin (Acetylsalicylic Acid) EP Impurity F

Carbasalate Calcium EP Impurity A

Acetylsalicylic Acid EP Impurity F (Carbasalate Calcium EP Impurity A)

2-(Acetyloxy)benzoic Anhydride (Acetylsalicylic Anhydride)

1466-82-6

C18H14O7

Building Blocks

Carboxylic Acid Anhydrides

Carbonyl Compounds

Organic Building Blocks

Impurities

Intermediates & Fine Chemicals

Pharmaceuticals