DIMETHYLPHOSPHINE OXIDE
- Product Name
- DIMETHYLPHOSPHINE OXIDE
- CAS No.
- 7211-39-4
- Chemical Name
- DIMETHYLPHOSPHINE OXIDE
- Synonyms
- methylphosphonoylmethane;Methylphosphinoylmethane;Einecs 230-591-2;Dimethylphosphinoxid;Dimethyl-Oxophosphonium;DIMETHYLPHOSPHINE OXIDE;imethyl(oxo)phosphanium;DIMETHYLPHOSPHINOUS ACID;dimethyl(oxo)phosphanium;Keto-Dimethyl-Phosphonium
- CBNumber
- CB7447743
- Molecular Formula
- C2H7OP
- Formula Weight
- 78.05
- MOL File
- 7211-39-4.mol
DIMETHYLPHOSPHINE OXIDE Property
- Boiling point:
- 65-67 °C(Press: 6 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- liquid
- color
- white solid to light yellow
- Sensitive
- air sensitive
- InChI
- InChI=1S/C2H7OP/c1-4(2)3/h4H,1-2H3
- InChIKey
- HGDIHUZVQPKSMO-UHFFFAOYSA-N
- SMILES
- P(=O)(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15-1425
- Product name
- Dimethylphosphine oxide, min. 95%
- Packaging
- 500mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 15-1425
- Product name
- Dimethylphosphine oxide, min. 95%
- Packaging
- 2g
- Price
- $278
- Updated
- 2024/03/01
- Product number
- FD166291
- Product name
- Dimethylphosphine oxide
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD166291
- Product name
- Dimethylphosphine oxide
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD166291
- Product name
- Dimethylphosphine oxide
- Packaging
- 2g
- Price
- $120
- Updated
- 2021/12/16
DIMETHYLPHOSPHINE OXIDE Chemical Properties,Usage,Production
Description
Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.
Chemical Properties
Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.
Uses
Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer. It is also used as an organic synthetic raw material for the preparation of (α-aminoalkyl)dimethylphosphine oxide enantiomers. Asymmetric synthesis of α-amino-α-polyfluoroalkyl dimethylphosphine oxides was accomplished through diastereoselective addition of dimethylphosphine oxide to enantiomeric Ellman's aldimines, RFCH=NS(O)tert-Bu (RF=CF3, CHF2, PhCF2).
Application
Dimethylphosphine oxide (DMPO) is a hydrogen bonding receptor that can be used to prepare ALK inhibitor compounds (WX-0593) containing DMPO molecules. The results of enzyme assay experiments showed that WX-0593 has high activity against wild-type and mutant ALK, and also inhibits ROS1WT in Ba/F3 cell line very well. In addition, WX-0593 is currently undergoing a phase I/II trial in ALK-positive NSCLC and is expected to be used for the treatment of ROS1-positive NSCLC.
Reactions
Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.
References
https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en®ion=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.
DIMETHYLPHOSPHINE OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DIMETHYLPHOSPHINE OXIDE manufacturers
- Product
- DIMETHYLPHOSPHINE OXIDE 7211-39-4
- Price
- US $20.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-23
- Product
- DIMETHYLPHOSPHINE OXIDE 7211-39-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- Dimethylphosphinoxid 7211-39-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 95%
- Supply Ability
- 20tons
- Release date
- 2024-05-28