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POMALIDOMIDE-C9-CO2H

Product Name
POMALIDOMIDE-C9-CO2H
CAS No.
2243000-24-8
Chemical Name
POMALIDOMIDE-C9-CO2H
Synonyms
Pomalidomide-C?-CO?H;Pomalidomide-C9-COOH;POMALIDOMIDE-C9-CO2H;Thalidomide-4-NH-C9-COOH;10-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino]decanoic Acid;Decanoic acid, 10-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-;10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber
CB74740493
Molecular Formula
C23H29N3O6
Formula Weight
443.49
MOL File
2243000-24-8.mol
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POMALIDOMIDE-C9-CO2H Property

Boiling point:
714.1±55.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder or crystals
pka
4.78±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Iris Biotech GmbH
Product number
PTC1120
Product name
Pomalidomide-C9-COOH
Packaging
50mg
Price
$432
Updated
2021/12/16
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POMALIDOMIDE-C9-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-C9-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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POMALIDOMIDE-C9-CO2H Suppliers

China 9 Japan 1 United States 2 Global 12
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View Lastest Price from POMALIDOMIDE-C9-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-C9-COOH 2243000-24-8
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
100mg
Release date
2024-04-01

2243000-24-8, POMALIDOMIDE-C9-CO2HRelated Search:

E3 ligase Ligand-Linker Conjugates 49 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Pomalidomide-C6-PEG3-butyl iodide 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Pomalidomide-C3-NH2 Pomalidomide-C6-NH2?hydrochloride Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

  • POMALIDOMIDE-C9-CO2H
  • Pomalidomide-C9-COOH
  • Decanoic acid, 10-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
  • 10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Thalidomide-4-NH-C9-COOH
  • 10-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino]decanoic Acid
  • Pomalidomide-C?-CO?H
  • 2243000-24-8