ChemicalBook > CAS DataBase List > MOTS-c

MOTS-c

Product Name
MOTS-c
CAS No.
1627580-64-6
Chemical Name
MOTS-c
Synonyms
MOTS-C acetate;MOTS-c;MOTS-c POWDER;Cosmetic Peptide Mots-C;L-Arginine, L-methionyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-α-glutamyl-L-methionylglycyl-L-tyrosyl-L-isoleucyl-L-phenylalanyl-L-tyrosyl-L-prolyl-L-arginyl-L-lysyl-L-leucyl-
CBNumber
CB74808537
Molecular Formula
C101H152N28O22S2
Formula Weight
2174.62
MOL File
1627580-64-6.mol
More
Less

MOTS-c Property

Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
color 
Solid lyophilized powder
Sequence
H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
InChI
InChI=1/C101H152N28O22S2/c1-7-57(4)83(96(148)126-76(50-58-19-9-8-10-20-58)92(144)127-78(52-60-30-34-63(131)35-31-60)97(149)129-46-18-27-79(129)95(147)122-69(25-16-44-112-100(107)108)86(138)118-67(23-13-14-42-102)87(139)124-74(49-56(2)3)91(143)123-73(98(150)151)26-17-45-113-101(109)110)128-94(146)75(51-59-28-32-62(130)33-29-59)116-81(133)55-115-85(137)72(41-48-153-6)121-90(142)71(37-39-82(134)135)119-89(141)70(36-38-80(104)132)120-93(145)77(53-61-54-114-66-22-12-11-21-64(61)66)125-88(140)68(24-15-43-111-99(105)106)117-84(136)65(103)40-47-152-5/h8-12,19-22,28-35,54,56-57,65,67-79,83,114,130-131H,7,13-18,23-27,36-53,55,102-103H2,1-6H3,(H2,104,132)(H,115,137)(H,116,133)(H,117,136)(H,118,138)(H,119,141)(H,120,145)(H,121,142)(H,122,147)(H,123,143)(H,124,139)(H,125,140)(H,126,148)(H,127,144)(H,128,146)(H,134,135)(H,150,151)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t57-,65-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-/s3
InChIKey
WYTHCOXVWRKRAH-JIJBDQHHNA-N
SMILES
C(C1=CNC2=CC=CC=C12)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@H](C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)CCCNC(N)=N)=O)CC1C=CC(O)=CC=1 |&1:10,14,25,34,43,52,64,68,70,77,88,102,106,117,126,134,r|
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Adipogen Life Sciences
Product number
AG-CP3-0026-M005
Product name
MOTS-c(human)
Purity
≥95%(HPLC)
Packaging
5mg
Price
$490
Updated
2021/12/16
More
Less

MOTS-c Chemical Properties,Usage,Production

Description

MOTS-c is a peptide hormone encoded in the mitochondrial genome. It regulates metabolic homeostasis and enhances physical performance. It is a mitochondria-derived peptide (MDP) that promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice. Potential anti-obesity and anti-aging compound.

Mechanism of action

MOTS-c targets skeletal muscle and can enhance glucose metabolism. Therefore, MOTS-c plays an important role in the regulation of cardiovascular, diabetes, exercise and longevity. It is a new mitochondrial signaling mechanism and plays a role in regulating intracellular and intercellular metabolism. This substance could triggers the activation of AMPK and accumulation of 5-aminomidazole-4-carboxamide ribonucleotide (AICAR), a known AMPK activator, by inhibiting the folate cycle and de novo purine biosynthesis[1-2].

Side effects

MOTS-c is reported to be safe in recommended dosages. The side effects of this compound include Injection site pruritus. As with all injections, redness and pain at the injection site may be present. As MOTS-c targets the folate cycle and de novo purine biosynthesis pathways, a depletion of intracellular 5-methyl tetrahydrofolate (5-MTHF) may occur when using MOTS-c protocols.

storage

+4°C

References

[1] Mohtashami Z, et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Mohtashami, 2022; 23: 11991.
[2] Zheng Y, et al. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 2023; 14: 1120533.

MOTS-c Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MOTS-c Suppliers

Australia 1 China 98 United States 1 Global 100
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
2358
Advantage
58
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Sichuan Taihui Biotechnology Co., Ltd
Tel
028-87189093 18599944286
Email
272503470@qq.com
Country
China
ProdList
99
Advantage
58
Hubei Zhaoke BIO-CHEMICAL Co., Ltd.
Tel
13533334465 13433334465
Email
312523773@qq.com
Country
China
ProdList
347
Advantage
58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
18014456767 18014456767
Email
wenxi@jszkhy.com
Country
China
ProdList
1349
Advantage
58
Dongguan Jiuzhe Biotechnology Co., Ltd
Tel
13316572034
Email
3986929230@qq.com
Country
China
ProdList
80
Advantage
58
Sichuan Takele Biotechnology Co., Ltd.
Tel
+86-028-64348587 15680781153
Email
sales@takelepeptide.com
Country
China
ProdList
89
Advantage
58
Wuhan Sunrise Technology Development Co., Ltd.
Tel
027-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
300
Advantage
62
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1992
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3980
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-83778895 18602735115
Fax
027-51119224
Email
18602735115@163.com
Country
China
ProdList
2000
Advantage
64
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
6347
Advantage
58
Sichuan Jisheng Biopharmaceutical Co.,Ltd.
Tel
+86-0833-2598983 +86-18086877136
Fax
+86-833-2598903
Email
Nyx-peptide@jsjpharm.cn
Country
China
ProdList
306
Advantage
58
Hebei Yime New Material Technology Co., Ltd.
Tel
+86-66697723 +86-17703311139
Email
admin@china-yime.com
Country
China
ProdList
563
Advantage
58
Shanghai Yunao International Trade Co., Ltd
Tel
+8617621705551
Email
asdf@shanghaihg.cn
Country
China
ProdList
265
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+8618339805032
Email
alfa4@alfachem.cn
Country
China
ProdList
12975
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10523
Advantage
58
Hubei Ipure Biology Co., Ltd
Tel
+8613367258412
Fax
18062427325
Email
ada@ipurechemical.com
Country
China
ProdList
10326
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921
Email
sales1@gotopbio.com
Country
CHINA
ProdList
2609
Advantage
58
Shanghai UCHEM Inc.
Tel
+862156762820 +86-13564624040
Email
sales@myuchem.com
Country
China
ProdList
6708
Advantage
58
HONG KONG IPURE BIOLOGY CO.,LIMITED
Tel
86 18062405514 18062405514
Email
ada@ipurechemical.com
Country
CHINA
ProdList
3465
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
Binhai gill polypeptide co. LTD
Tel
021-61263389 13524856427
Fax
WeChat630417570
Email
Joetang@glschina.com
Country
China
ProdList
9618
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19901447308
Email
260924549@qq.com
Country
China
ProdList
8742
Advantage
58
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
999
Advantage
58
Nanjing chengqimei Biotechnology Co., Ltd
Tel
19850819832
Email
2173594524@qq.com
Country
China
ProdList
2638
Advantage
58
Xi'an Laina Biotechnology Co., Ltd
Tel
029-029-84161958 18629577295
Fax
029-84161958
Email
jack@lynabio.com
Country
China
ProdList
628
Advantage
55
Nanjing shengyilai Chemical Co., Ltd
Tel
19951936396
Email
3158688292@qq.com
Country
China
ProdList
4840
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14092
Advantage
58
Wuhan Wiseman Bioengineering Co.,Ltd
Tel
027-59506022 13419526507
Fax
027-59506022
Email
13419526507@163.com
Country
China
ProdList
2931
Advantage
58
Shaanxi Pioneer Biotech Co., Ltd
Tel
029-84385017-8003 13259417953
Fax
QQ1477918929
Email
sales@pioneerbiotech.com
Country
China
ProdList
425
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921 13355716090
Email
Sales@gotopbio.com
Country
China
ProdList
2831
Advantage
58
Hubei Zhongshan Medical Technology Co., Ltd
Tel
027-61907345 13397111514
Fax
3443707954
Email
w13397111514@163.com
Country
China
ProdList
1011
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7955
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31163
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815987 13927875076
Fax
0751-2828607
Email
3007432263@qq.com
Country
China
ProdList
9978
Advantage
58
Nanjing Yuanpeptide Biotech Co.，Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
Country
China
ProdList
2977
Advantage
58
Chengdu Jinglin Biotechnology Co., Ltd.
Tel
17711399154
Email
3211919385@qq.com
Country
China
ProdList
1815
Advantage
58
Hubei Benofu Chemical Technology Co., Ltd.
Tel
15307183689
Email
393985636@qq.com
Country
China
ProdList
3005
Advantage
58
Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-88211921 15572296305
Email
sales4@gotopbio.com
Country
China
ProdList
5144
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
5950
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-59105166 13125137732
Email
2853863890@qq.com
Country
China
ProdList
2889
Advantage
58
Hebei ruqi technology co., ltd
Tel
176-03256889 17603256889
Email
1123722730@qq.com
Country
China
ProdList
3390
Advantage
58
Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.
Tel
18671296875
Email
1205035102@qq.com
Country
China
ProdList
4069
Advantage
58
Hangzhou Yijing Technology Co., Ltd
Tel
15068777134
Email
1289372011@qq.com
Country
China
ProdList
1611
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4547
Advantage
58
Shanghai Weiyuxi Biotechnology Co. , Ltd.
Tel
021-54707036 13370210043
Email
Lily.xiang@wayxbio.com
Country
China
ProdList
239
Advantage
58
Shanghai Toyang Biotechnology Co., LTD
Tel
021-59555769 13524932310
Fax
021-50342869
Email
1405894150@qq.com
Country
China
ProdList
8221
Advantage
58
More
Less

View Lastest Price from MOTS-c manufacturers

Shanghai Affida new material science and technology center
Product
MOTS-c POWDER 1627580-64-6
Price
US $0.00-0.00/Box
Min. Order
1Box
Purity
99
Supply Ability
50000KG/month
Release date
2024-04-09
Shanghai Affida new material science and technology center
Product
MOTS-c 1627580-64-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
50000KG/month
Release date
2024-05-06
Dorne Chemical Technology co. LTD
Product
MOTS-c 1627580-64-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26

1627580-64-6, MOTS-cRelated Search:

PalMitoyl Tripeptide-1 Abaloparatide Irofulven Dermorphin Etelcalcetide Acetyl Hexapeptide-1 GLUCAGON (1-37) (PORCINE) N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine Melanotan 1 Palmitoyl Hexapeptide-12 Pexiganan omiganan pentahydrochloride Acetyl Decapeptide-3

  • MOTS-c
  • L-Arginine, L-methionyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-α-glutamyl-L-methionylglycyl-L-tyrosyl-L-isoleucyl-L-phenylalanyl-L-tyrosyl-L-prolyl-L-arginyl-L-lysyl-L-leucyl-
  • MOTS-C acetate
  • Cosmetic Peptide Mots-C
  • MOTS-c POWDER
  • 1627580-64-6
  • 1627580-64-7
  • C101H152N28O22S2