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MOTS-c

Product Name
MOTS-c
CAS No.
1627580-64-6
Chemical Name
MOTS-c
Synonyms
MOTS-C acetate;MOTS-c;MOTS-c POWDER;MOTS-c peptide;Cosmetic Peptide Mots-C;L-Arginine, L-methionyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-α-glutamyl-L-methionylglycyl-L-tyrosyl-L-isoleucyl-L-phenylalanyl-L-tyrosyl-L-prolyl-L-arginyl-L-lysyl-L-leucyl-
CBNumber
CB74808537
Molecular Formula
C101H152N28O22S2
Formula Weight
2174.62
MOL File
1627580-64-6.mol
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MOTS-c Property

Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
color 
Solid lyophilized powder
Sequence
H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
InChI
InChI=1/C101H152N28O22S2/c1-7-57(4)83(96(148)126-76(50-58-19-9-8-10-20-58)92(144)127-78(52-60-30-34-63(131)35-31-60)97(149)129-46-18-27-79(129)95(147)122-69(25-16-44-112-100(107)108)86(138)118-67(23-13-14-42-102)87(139)124-74(49-56(2)3)91(143)123-73(98(150)151)26-17-45-113-101(109)110)128-94(146)75(51-59-28-32-62(130)33-29-59)116-81(133)55-115-85(137)72(41-48-153-6)121-90(142)71(37-39-82(134)135)119-89(141)70(36-38-80(104)132)120-93(145)77(53-61-54-114-66-22-12-11-21-64(61)66)125-88(140)68(24-15-43-111-99(105)106)117-84(136)65(103)40-47-152-5/h8-12,19-22,28-35,54,56-57,65,67-79,83,114,130-131H,7,13-18,23-27,36-53,55,102-103H2,1-6H3,(H2,104,132)(H,115,137)(H,116,133)(H,117,136)(H,118,138)(H,119,141)(H,120,145)(H,121,142)(H,122,147)(H,123,143)(H,124,139)(H,125,140)(H,126,148)(H,127,144)(H,128,146)(H,134,135)(H,150,151)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t57-,65-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-/s3
InChIKey
WYTHCOXVWRKRAH-JIJBDQHHNA-N
SMILES
C(C1=CNC2=CC=CC=C12)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@H](C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)CCCNC(N)=N)=O)CC1C=CC(O)=CC=1 |&1:10,14,25,34,43,52,64,68,70,77,88,102,106,117,126,134,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences
Product number
AG-CP3-0026-M005
Product name
MOTS-c(human)
Purity
≥95%(HPLC)
Packaging
5mg
Price
$490
Updated
2021/12/16
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MOTS-c Chemical Properties,Usage,Production

Description

MOTS-c is a peptide hormone encoded in the mitochondrial genome. It regulates metabolic homeostasis and enhances physical performance. It is a mitochondria-derived peptide (MDP) that promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice. Potential anti-obesity and anti-aging compound.

Biological Functions

MOTS-c, as a mitochondrial coding regulator, has endocrine-like and nuclear transcriptional regulation on muscle metabolism, insulin sensitivity and body weight. Approximately 11.9-fold increase in endogenous MOTS-c levels has been found in skeletal muscle following exercise (compared to pre-exercise values), and this increase can remain for 4 hours following exercise. In addition, circulating endogenous MOTS-c levels increase 1.6-fold during exercise, 1.5-fold after exercise, and then return to baseline levels after 4 hours. MOTS-c, as a new type of mitochondrial signal molecule, may stimulate exercise-mediated physiological responses to increase endurance. Therefore, MOTS-c can be used as a motion simulator to mediate the function of the motion signal system.
MOTS-c has also been found to be involved in the regulation of nuclear gene expression by binding to transcription factors. Under resting conditions, MOTS-c is mainly distributed in the mitochondria outside the nucleus. When metabolic stress occurs, MOTS-c in cells can be transferred to the nucleus in an AMPK-dependent manner and bind to transcription factors regulated by ARE, thus improving the stress resistance of cells.
Furthermore, MOTS-c plays the role of endocrine-like factors by regulating nuclear transcription to restore homeostasis. The function may have important implications for age-related diseases in response to metabolic stress by promoting intracellular homeostasis, and MOTS-c gene polymorphisms are associated with human lifespan. Moreover, MOTS-c may improve diabetes by inhibiting insulin resistance and diet-induced obesity. MOTS-c can promote glucose utilization, inhibit oxidative stress, activate NF-κB to inhibit inflammation, and effectively protect coronary artery endothelial cell dysfunction[3].

Mechanism of action

MOTS-c targets skeletal muscle and can enhance glucose metabolism. Therefore, MOTS-c plays an important role in the regulation of cardiovascular, diabetes, exercise and longevity. It is a new mitochondrial signaling mechanism and plays a role in regulating intracellular and intercellular metabolism. This substance could triggers the activation of AMPK and accumulation of 5-aminomidazole-4-carboxamide ribonucleotide (AICAR), a known AMPK activator, by inhibiting the folate cycle and de novo purine biosynthesis[1-2].

Side effects

MOTS-c is reported to be safe in recommended dosages. The side effects of this compound include Injection site pruritus. As with all injections, redness and pain at the injection site may be present. As MOTS-c targets the folate cycle and de novo purine biosynthesis pathways, a depletion of intracellular 5-methyl tetrahydrofolate (5-MTHF) may occur when using MOTS-c protocols.

storage

+4°C

References

[1] Mohtashami Z, et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Mohtashami, 2022; 23: 11991.
[2] Zheng Y, et al. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 2023; 14: 1120533.
[3] Yuejun Zheng, Tianhui Wang, Zilin Wei. “MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.” Frontiers in Endocrinology 14 (2023): 1120533.

MOTS-c Preparation Products And Raw materials

Raw materials

Preparation Products

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MOTS-c Suppliers

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View Lastest Price from MOTS-c manufacturers

Dorne Chemical Technology co. LTD
Product
MOTS-c 1627580-64-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
CONTIDE BIOTECH CO.,LTD
Product
MOTS-c 1627580-64-6
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-10-17
hebei hongtan Biotechnology Co., Ltd
Product
MOTS-c(human) 1627580-64-6
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000kg
Release date
2024-03-21

1627580-64-6, MOTS-cRelated Search:

PalMitoyl Tripeptide-1 Abaloparatide Irofulven Dermorphin Etelcalcetide Acetyl Hexapeptide-1 GLUCAGON (1-37) (PORCINE) N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine Melanotan 1 Palmitoyl Hexapeptide-12 Pexiganan omiganan pentahydrochloride Acetyl Decapeptide-3

  • MOTS-c
  • L-Arginine, L-methionyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-α-glutamyl-L-methionylglycyl-L-tyrosyl-L-isoleucyl-L-phenylalanyl-L-tyrosyl-L-prolyl-L-arginyl-L-lysyl-L-leucyl-
  • MOTS-C acetate
  • Cosmetic Peptide Mots-C
  • MOTS-c POWDER
  • MOTS-c peptide
  • 1627580-64-6
  • 1627580-64-7
  • C101H152N28O22S2