ACEA

Product Name: ACEA
CAS No.: 220556-69-4
Chemical Name: ACEA
Synonyms: ACEA;2'-CHLORO-AEA;ACEA (ethanol solution);Terfenadine Impurity 23;ARACHIDONYL-2-CHLOROETHYLAMIDE;ARACHIDONYL-2'-CHLOROETHYLAMIDE;ARACHIDONOYL 2'-CHLOROETHYLAMIDE;Arachidonoyl 2'-Chloroethylamide;Eicosapentaenoic Acid Impurity 51;ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE
CBNumber: CB7484072
Molecular Formula: C22H36ClNO
Formula Weight: 365.98
MOL File: 220556-69-4.mol

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ACEA Property

RTECS: JX3840800
storage temp.: −20°C
solubility: DMSO: soluble
form: oil
color: pale yellow
Sensitive: Air Sensitive

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9719
Product name: Arachidonyl-2′-chloroethylamide hydrate
Purity: ≥97% (HPLC), oil
Packaging: 25mg
Price: $398
Updated: 2024/03/01

Alfa Aesar

Product number: J67294
Product name: N-Arachidonyl-2-chloroethylamide, 98%
Packaging: 10mg
Price: $117
Updated: 2022/04/27

Cayman Chemical

Product number: 91054
Product name: Arachidonoyl 2'-Chloroethylamide
Purity: ≥95%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 91054
Product name: Arachidonoyl 2'-Chloroethylamide
Purity: ≥95%
Packaging: 10mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 91054
Product name: Arachidonoyl 2'-Chloroethylamide
Purity: ≥95%
Packaging: 25mg
Price: $166
Updated: 2024/03/01

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ACEA Chemical Properties,Usage,Production

Description

Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with K_i values of 1.4 and >2,000 nM for CB₁ and CB₂ receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB₁ receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

Uses

A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).

Definition

ChEBI: Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB1 receptor agonist, a neuroprotective agent and a CB2 receptor agonist. It is an organochlorine compound, a secondary carboxamide, a fatty amide and a synthetic cannabinoid. It is functionally related to an arachidonic acid.

Biological Activity

Potent and highly selective CB 1 receptor agonist (K i = 1.4 nM). Displays > 1400-fold selectivity over CB 2 receptors. Active in vivo . Also available as part of the Cannabinoid CB 1 Receptor Tocriset™ .

Biochem/physiol Actions

Potent and selective neuronal CB1 cannabinoid receptor agonist.

Enzyme inhibitor

This synthetic CB1 receptor agonist and anandamide (N- arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki = 1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM). ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [ 35 S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. ACEA produces hypothermia in mice, an effect that is inhibited by co-administration of the CB1 receptor antagonist SR141716A.

storage

Store at -20°C

ACEA Preparation Products And Raw materials

Raw materials

Preparation Products

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ACEA Suppliers

Canada 1 China 34 Europe 1 Germany 3 Switzerland 1 United Kingdom 4 United States 5 Global 49

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220556-69-4, ACEARelated Search:

NOLADIN ETHER MEAD ACID ETHANOLAMIDE AM 630 2-AG BML-190 ACPA 5-(1,1-DIMETHYLHEPTYL)-2-[5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE ARACHIDONIC ACID-(2-AMINOETHYL)-ESTER HYDROCHLORIDE AM 251 ARACHIDONAMIDE ACEA-1021 ACEA 1011 AceA protein ACEA ACEA

N-(2-CHLOROETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE

ARACHIDONYL-2'-CHLOROETHYLAMIDE

ARACHIDONYL-2-CHLOROETHYLAMIDE

ARACHIDONOYL 2'-CHLOROETHYLAMIDE

ACEA

2'-CHLORO-AEA

ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE

ACEA (ethanol solution)

(5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)-5,8,11,14-eicosatetraenaMide

5,8,11,14-Eicosatetraenamide, N-(2-chloroethyl)-, (5Z,8Z,11Z,14Z)-

Arachidonoyl 2'Chloroethylamide,Arachidonoyl 2' Chloroethylamide

Eicosapentaenoic Acid Impurity 51

Arachidonoyl 2'-Chloroethylamide

Terfenadine Impurity 23

220556-69-4

C22H36ClNO

Cannabinoid receptor

Cannabinoid

Agonist

Fatty Acid Derivatives & Lipids

Glycerols

Intermediates & Fine Chemicals

Pharmaceuticals