ACEA
- Product Name
- ACEA
- CAS No.
- 220556-69-4
- Chemical Name
- ACEA
- Synonyms
- ACEA;2'-CHLORO-AEA;ACEA (ethanol solution);Terfenadine Impurity 23;ARACHIDONYL-2-CHLOROETHYLAMIDE;ARACHIDONYL-2'-CHLOROETHYLAMIDE;ARACHIDONOYL 2'-CHLOROETHYLAMIDE;Eicosapentaenoic Acid Impurity 51;ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE;N-(2-CHLOROETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
- CBNumber
- CB7484072
- Molecular Formula
- C22H36ClNO
- Formula Weight
- 365.98
- MOL File
- 220556-69-4.mol
ACEA Property
- RTECS
- JX3840800
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- oil
- color
- pale yellow
- Sensitive
- Air Sensitive
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A9719
- Product name
- Arachidonyl-2′-chloroethylamide hydrate
- Purity
- ≥97% (HPLC), oil
- Packaging
- 25mg
- Price
- $398
- Updated
- 2024/03/01
- Product number
- J67294
- Product name
- N-Arachidonyl-2-chloroethylamide, 98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2022/04/27
- Product number
- 91054
- Product name
- Arachidonoyl 2'-Chloroethylamide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 91054
- Product name
- Arachidonoyl 2'-Chloroethylamide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 91054
- Product name
- Arachidonoyl 2'-Chloroethylamide
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
ACEA Chemical Properties,Usage,Production
Description
Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
Uses
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).
Definition
ChEBI: Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB1 receptor agonist, a neuroprotective agent and a CB2 receptor agonist. It is an organochlorine compound, a secondary carboxamide, a fatty amide and a synthetic cannabinoid. It is functionally related to an arachidonic acid.
Biological Activity
Potent and highly selective CB 1 receptor agonist (K i = 1.4 nM). Displays > 1400-fold selectivity over CB 2 receptors. Active in vivo . Also available as part of the Cannabinoid CB 1 Receptor Tocriset™ .
Biochem/physiol Actions
Potent and selective neuronal CB1 cannabinoid receptor agonist.
Enzyme inhibitor
This synthetic CB1 receptor agonist and anandamide (N- arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki = 1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM). ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [ 35 S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. ACEA produces hypothermia in mice, an effect that is inhibited by co-administration of the CB1 receptor antagonist SR141716A.
storage
Store at -20°C