Hydroxyprogesterone acetate

Product Name: Hydroxyprogesterone acetate
CAS No.: 302-23-8
Chemical Name: Hydroxyprogesterone acetate
Synonyms: acetoxyprogesterone;17a-Acetoxyprogesterone;17α-hydroxyprogesterone 17-acetate;3,20-dioxopregn-4-en-17-yl acetate;17-ap;u5533;prodoxacetate;6,7-Dehydro-17α17α-Acetoxyprogesterone;Rivastigmine Impurity 51
CBNumber: CB7502523
Molecular Formula: C23H32O4
Formula Weight: 372.5
MOL File: 302-23-8.mol

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Hydroxyprogesterone acetate Property

Melting point:: 249-250°C
Boiling point:: 421.94°C (rough estimate)
Density: 1.0415 (rough estimate)
refractive index: 1.4433 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
Water Solubility: 1.01mg/L at 20℃
λmax: 241nm(EtOH)(lit.)
BRN: 2227870
InChI: InChI=1S/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23+/m1/s1
InChIKey: VTHUYJIXSMGYOQ-KOORYGTMSA-N
SMILES: C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)CC2
CAS DataBase Reference: 302-23-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 40-48
Safety Statements: 22-24/25-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TU5074000
HS Code: 29372390

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H351Suspected of causing cancer
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001656
Product name: Chlormadinone acetate impurity G
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 25 mg
Price: $162
Updated: 2025/07/31

Sigma-Aldrich

Product number: S517917
Product name: 17ALPHA-ACETOXYPROGESTERONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S517917
Product name: 17ALPHA-ACETOXYPROGESTERONE
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: A4125
Product name: 17α-Hydroxyprogesterone 17-acetate
Purity: ≥98%
Packaging: 5g
Price: $192
Updated: 2023/06/20

TCI Chemical

Product number: H1527
Product name: 17α-Hydroxyprogesterone Acetate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $49
Updated: 2025/07/31

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Hydroxyprogesterone acetate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Progesterone Acetate (Megestrol Acetate EP Impurity K) is an impurity in steroid drug Megestrol acetate (M208050).

Uses

An impurity in steroid drug Megestrol acetate (M208050).

Synthesis

83984-86-5

4134-58-1

The general procedure for the synthesis of the target compound (CAS: 4134-58-1) using the compound (CAS: 83984-86-5) as starting material was as follows: the diester (51 g, melting point 192-196°C) was dissolved in a solvent mixture of 1.4 liters of technical grade xylene and 510 ml of cyclohexanone. Water was removed from the system by distillation (250 ml of distillate was collected). Subsequently, aluminum isopropoxide (51 g) dissolved in 210 ml of xylene was added dropwise to the reaction system over a period of 5 minutes under slow distillation conditions, and distillation was continued for 45 minutes (another 210 ml of distillate was collected). Upon completion of the reaction, the mixture was rapidly cooled, the reaction was quenched by the addition of an ice-water mixture, and the remaining solvent was removed by steam distillation. The resulting solid product was collected by filtration and dried. The crude product was extracted using hot acetone and subsequently recrystallized by acetone to give 40.7 g (86% yield) of 17α-acetoxy-progesterone with a melting point of 240-243 °C. The melting point of the further purified sample was raised to 243-247 °C. *The 2% yield of the raw material is equivalent to 78.95%.

References

[1] Patent: EP1359154, 2003, A1. Location in patent: Page/Page column 16; 28; 30; 32
[2] Journal of the American Chemical Society, 1956, vol. 78, p. 820,823

Hydroxyprogesterone acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxyprogesterone acetate Suppliers

Americas 1 Canada 3 China 276 China Hong Kong 1 Europe 3 Germany 6 India 13 Japan 2 Poland 1 Slovakia 1 Switzerland 1 United Kingdom 7 United States 24 Global 339

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View Lastest Price from Hydroxyprogesterone acetate manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Hydroxyprogesterone acetate 302-23-8
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Hydroxyprogesterone acetate 302-23-8
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97%-102%
Supply Ability: 100kg
Release date: 2021-08-05

Wuhan Biocar Pharmacy CO.,Ltd.

Product: Hydroxyprogesterone acetate 302-23-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 800kg
Release date: 2025-02-26

302-23-8, Hydroxyprogesterone acetateRelated Search:

Ammonium acetate 4-(Diethylamino)salicylaldehyde Benzyl acetate Sodium acetate DL-α-Tocopherol Isopropyl acetate CHLOROPHOSPHONAZO III Cellulose acetate Ethyl acetate Diphenolic acid 5-Chlorovaleric acid Pralmorelin Butyl acetate Vinyl acetate Medroxyprogesterone Acetate Megestrol acetate Cyproterone acetate Magnesium acetate

6-Bromo-6-dehydro-17&alpha

6,7-Dehydro-17&alpha

17A-HYDROXYPROGESTERONE 17-ACETATE VETRA

17-alpha-Hydroxylprogesterone

17α-acetoxy-4-pregnene-3,20-dione

17α-hydroxyprogesterone 17-acetate

HYDROXYPROGESTERONE, 17a-(RG)

17a-Acetoxyprogesterone

17a-Hydroxy-4-pregnene-3,20-dione acetate

17a-Hydroxyprogesterone acetate

Hydroxyprogesterone acetate

17α-Hydroxylprogesterone acetate

17α-Acetoxy-4-pregnene-3,20-dione, 17α-Acetoxyprogesterone, 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate, 4-Pregnen-17α-ol-3,20-dione acetate

17α-Acetoxypregn-4-ene-3,20-dione

17α-Hydroxyprogesterone 17-acetate,17α-Acetoxy-4-pregnene-3,20-dione, 17α-Acetoxyprogesterone, 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate, 4-Pregnen-17α-ol-3,20-dione acetate

17-(Acetyloxy)progesterone

17A-HYDROXYPROGESTERONE 17-ACETATE

17-(acetyloxy)-pregn-4-ene-20-dione

17-ap

N-(4-ethylsulfonylphenyl)carbamic acid cyclohexyl ester

Medroxyprogesterone EP Impurity H

Medroxyprogesterone Acetate EP Impurity H (17-alpha-Acetoxy Progesterone)

17a-Hydroxypregn-4-Monoene-3,20-Dione-17-Acetate

20-dione,17-hydroxy-pregn-4-ene-acetate

acetoxyprogesterone

prodoxacetate

u5533

Hydroxyprogesterone acetate 17a-Acetoxyprogesterone

17-α-Hydroxyprogesterone Solution, 100ppm

17α-Hydroxy-4-pregnene-3,20-dione 17-acetate

Chlormadinone acetate impurity G

17a- hydroxyprogesterone acetate (monoester)

3,20-dioxopregn-4-en-17-yl acetate

Megestrol acetate EP Impurity K

(8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tet

Medroxyprogesterone Acetate EP impurity H

Megestrol Acetate Impurity 11(Megestrol Acetate EP Impurity K)

Chlormadinone acetate impurity G CRS

17α-HydroxyprogesteroneAcetate&gt

Chlormadinone Acetate EP Impurity G

Pregn-4-ene-3,20-dione, 17-(acetyloxy)-

(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

17alpha-Acetoxypregn-4-ene-3,20-dione

17alpha-Hydroxypregn-4-ene-3,20-diene Acetate

Hydroxyprogesterone acetate USP/EP/BP

17Α-HYDROXY-PROGESTERONE ACETATE

Hydroxyprogesterone acetater

Chlormadinone acetate impurity G (Y0001656)

TIANFUCHEM--High purity 302-23-8 Hydroxyprogesterone acetate

Hydroxyprogesterone vinegar

inhibit,17α Hydroxyprogesterone acetate,17αHydroxyprogesterone acetate,17α-Hydroxyprogesterone,Inhibitor

17α-Hydroxyprogesterone acetate (Megestrol Acetate Impurity)

Medroxyprogesterone Acetate Impurity H

seventeen α Hydroxyprogesterone acetate

C14241010 17-alpha-HydroxyprogesteronE17-ace

Medroxyprogesterone Acetate EP Impurity H (Chlormadinone Acetate EP Impurity G, Megestrol Acetate EP Impurity K, 17-alpha-Acetoxy Progesterone)

Rivastigmine Impurity 51

Medroxyprogesterone Acetate Impurity 8 (Medroxyprogesterone Acetate EP Impurity H)