ChemicalBook > CAS DataBase List > 4-Chloro-6-methyl-2-(methylthio)pyrimidine

4-Chloro-6-methyl-2-(methylthio)pyrimidine

Product Name
4-Chloro-6-methyl-2-(methylthio)pyrimidine
CAS No.
17119-73-2
Chemical Name
4-Chloro-6-methyl-2-(methylthio)pyrimidine
Synonyms
NSC 48354;4-Chloro-6-methyl-2-(methylthio);4-Chloro-6-methyl-2-methylsulfany;4,6-dichloro-2-MethylpyriMidine-1-thiol;4-Chloro-6-methyl-2-(methylthio)pyrimidine;4-CHLORO-6-METHYL-2-METHYLSULFANYL-PYRIMIDINE;Pyrimidine, 4-chloro-6-methyl-2-(methylthio)-;4-Chloro-6-methyl-2-(methylthio)pyrimidine >4-chloro-6-methyl-2-(methylthio)pyrimidine(SALTDATA: FREE)
CBNumber
CB7663118
Molecular Formula
C6H7ClN2S
Formula Weight
174.65
MOL File
17119-73-2.mol
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4-Chloro-6-methyl-2-(methylthio)pyrimidine Property

Melting point:
37-38℃
Boiling point:
147°C/32mmHg(lit.)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Sparingly), MEthanol (Slightly)
form 
Solid
pka
0.16±0.30(Predicted)
color 
Pale Yellow
InChI
InChI=1S/C6H7ClN2S/c1-4-3-5(7)9-6(8-4)10-2/h3H,1-2H3
InChIKey
ALMBOXQFPLQVLF-UHFFFAOYSA-N
SMILES
C1(SC)=NC(C)=CC(Cl)=N1
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Safety

Risk Statements 
22
Safety Statements 
36/37
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S344354
Product name
4-CHLORO-6-METHYL-2-METHYLTHIOPYRIMIDINE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S344354
Product name
4-CHLORO-6-METHYL-2-METHYLTHIOPYRIMIDINE
Purity
Aldrich
Packaging
250mg
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
C2952
Product name
4-Chloro-6-methyl-2-(methylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
1g
Price
$444
Updated
2025/07/31
TRC
Product number
C378580
Product name
4-Chloro-6-methyl-2-(methylthio)pyrimidine
Packaging
5g
Price
$325
Updated
2021/12/16
Matrix Scientific
Product number
070693
Product name
4-Chloro-6-methyl-2-(methylthio)pyrimidine
Purity
98%
Packaging
1g
Price
$27
Updated
2021/12/16
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4-Chloro-6-methyl-2-(methylthio)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-Chloro-6-methyl-2-(methylthio)pyrimidine has been used in the synthesis of 4-chloro-2-(3,5-dimethyl-1h-pyrazol-1-yl)-6-methylpyrimidine.

Synthesis

6328-58-1

17119-73-2

A. Synthesis of 6-methyl-2-methylthio-4-chloropyrimidine: 6-methyl-4-hydroxy-2-methylthio-pyrimidine (9.20 g, 59 mmol) was mixed with phosphorus trichloride (60 mL) and heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into crushed ice. The aqueous phase mixture was extracted with ethyl acetate and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and water and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give 6-methyl-2-methylthio-4-chloropyrimidine (8.27 g, 80% yield) as a white solid with a melting point of 37-38°C. The solvent was removed by concentration under reduced pressure.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1146 - 1157
[2] Patent: US5863924, 1999, A
[3] Patent: US5958934, 1999, A
[4] Patent: US5952331, 1999, A
[5] Patent: EP901474, 2006, B1. Location in patent: Page/Page column 26

4-Chloro-6-methyl-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Phosphorus oxitrichloride 2-Methyl-2-thiopseudourea sulfate Sodium carbonate

Preparation Products

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View Lastest Price from 4-Chloro-6-methyl-2-(methylthio)pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine 17119-73-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
4-Chloro-6-methyl-2-(methylthio)pyrimidine 17119-73-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

17119-73-2, 4-Chloro-6-methyl-2-(methylthio)pyrimidineRelated Search:

Bensulfuron methyl Methyl salicylate Dimethyl sulfide 4-Vinylbenzyl chloride Kresoxim-methyl METSULFURON METHYL tert-Butyldimethylsilyl chloride Pirimiphos-methyl 4-(Chloromethyl)benzoic acid 2-Chloro-5-chloromethylpyridine Methylparaben ISOMETHIOZIN Thiophanate-methyl Methyl Difluorochloromethane 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE Chloromethyl methyl ether 4,6-Dichloro-2-(methylsulfonyl)pyrimidine

  • 4-CHLORO-6-METHYL-2-METHYLSULFANYL-PYRIMIDINE
  • 4-Chloro-6-methyl-2-(methylthio)pyrimidine
  • 4-chloro-6-methyl-2-(methylthio)pyrimidine(SALTDATA: FREE)
  • 4,6-dichloro-2-MethylpyriMidine-1-thiol
  • NSC 48354
  • 4-Chloro-6-methyl-2-(methylthio)
  • 4-Chloro-6-methyl-2-(methylthio)pyrimidine &gt
  • Pyrimidine, 4-chloro-6-methyl-2-(methylthio)-
  • 4-Chloro-6-methyl-2-methylsulfany
  • 17119-73-2
  • Heterocycle-Pyrimidine series