5-Bromothiazole Property

Melting point:

131-132 °C(Solv: ligroine (8032-32-4))

Boiling point:

80-81°C/18mm

Density 

1.835 at 25 °C

refractive index 

1.5955

Flash point:

170°F

pka

1.00±0.10(Predicted)

form 

Liquid

color 

Clear yellow to brown

Water Solubility 

Soluble in water.

Sensitive 

Moisture Sensitive

CAS DataBase Reference

3034-55-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-43

Safety Statements 

26-36/37/39

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

HS Code 

29341000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-Bromothiazole Chemical Properties,Usage,Production

Uses

5-Bromothiazole is used as a pharmaceutical intermediate and performance material.

General Description

5-Bromothiazole is a monobromothiazole, which can be prepared via treatment of 2,5-dibromothiazole with sodium ethoxide followed by hydrogenation over spongy nickel.

Purification Methods

If bromothiazole is too coloured, then suspend it in dilute NaOH and steam distil it. Add NaCl to the aqueous distillate, extract it with Et2O, dry it (Na2SO4), evaporate and fractionate the residue in a vacuum. The HgCl2 salt crystallises from EtOH with m 148o (dec). [Beyerman et al. Recl Trav Chim, Pays Bas 73 330 1954, Beilstein 27 III/IV 962.]