ChemicalBook > CAS DataBase List > 3-Cyano-6-methyl-2(1H)-pyridinone

3-Cyano-6-methyl-2(1H)-pyridinone

Product Name: 3-Cyano-6-methyl-2(1H)-pyridinone
CAS No.: 4241-27-4
Chemical Name: 3-Cyano-6-methyl-2(1H)-pyridinone
Synonyms: NSC 15124;3-CYANO-6-METHYL-2-PYRIDONE;6-METHYL-3-CYANO-2-PYRIDONE;6-Methyl-3-cyanopyridin-2ol;5-cyano-6-hydroxy-2-picoline;3-Cyano-6-methyl-2-pyridinol;3-Cyano-6-methyl-2-pyridone,98%;3-cyano-6-methyl-2(1h)-pyridone;3-Cyano-6-methyl-2-pyridone >3-cyano-6-methyl-2(H)pyridinone
CBNumber: CB7672912
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 4241-27-4.mol

Less

3-Cyano-6-methyl-2(1H)-pyridinone Property

Melting point:: 293-295 °C (lit.)
Boiling point:: 247.23°C (rough estimate)
Density: 1.2296 (rough estimate)
refractive index: 1.5880 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.03±0.10(Predicted)
color: White to Pale Yellow
Water Solubility: 2.38 g/L (20 ºC)
BRN: 120412
InChI: InChI=1S/C7H6N2O/c1-5-2-3-6(4-8)7(10)9-5/h2-3H,1H3,(H,9,10)
InChIKey: FIMGYEKEYXUTGD-UHFFFAOYSA-N
SMILES: C1(=O)NC(C)=CC=C1C#N
CAS DataBase Reference: 4241-27-4(CAS DataBase Reference)
EPA Substance Registry System: 3-Pyridinecarbonitrile, 1,2-dihydro-6-methyl-2-oxo- (4241-27-4)

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 36/37/39-26-22-36
RIDADR: 3276
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
PackingGroup: III
HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 278246
Product name: 3-Cyano-6-methyl-2(1H)-pyridinone
Purity: 97%
Packaging: 5g
Price: $89.1
Updated: 2023/01/07

TCI Chemical

Product number: C2210
Product name: 3-Cyano-6-methyl-2-pyridone
Purity: >98.0%(T)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: C2210
Product name: 3-Cyano-6-methyl-2-pyridone
Purity: >98.0%(T)
Packaging: 25g
Price: $173
Updated: 2025/07/31

TRC

Product number: C981880
Product name: 3-Cyano-6-methyl-2(1H)-pyridinone
Packaging: 10g
Price: $100
Updated: 2021/12/16

Oakwood

Product number: 018469
Product name: 3-Cyano-6-methyl-2-pyridone
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Less

3-Cyano-6-methyl-2(1H)-pyridinone Chemical Properties,Usage,Production

Chemical Properties

SLIGHTLY YELLOW GRANULAR CRYSTALLINE POWDER

Uses

3-Cyano-6-methyl-2(1H)-pyridinone is a reactant used in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. 3-It has also been used in the preparation of the N3?-pyridyl thiamine, a potent in vitro thiamine antagonist.

General Description

Supramolecular structures of coordination copper(I) compounds of 3-cyano-6-methyl-2(1H)-pyridinone has been investigated.

Synthesis

67-64-1

107-91-5

109-94-4

4241-27-4

A 950 ml solution of tetrahydrofuran (THF) with 46.5 g of sodium methanolate was added to the reaction vessel and cooled in an ice bath to an internal temperature of 0 to 5°C. Subsequently, a mixed solution of 46.5 g of acetone and 59.6 g of ethyl formate was slowly added with a controlled drip time of 1 hour. After the dropwise addition, the ice bath was removed and the reaction system was allowed to slowly warm up to room temperature within 1 hour. Afterwards, the reaction solution was concentrated under reduced pressure (temperature not exceeding 50°C). The concentrate was transferred to another reaction vessel, 400 ml of aqueous solution of 67 g of cyanoacetamide and an appropriate amount of piperidine acetic acid (as a condensation catalyst) were added, and the reaction was refluxed for 2 hours. Upon completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted with acetic acid to about 5. The reaction mixture was allowed to stand at room temperature overnight and subsequently cooled in an ice bath for 45 minutes for filtration. The filter cake was washed three times with ice water and finally dried under vacuum at 80 °C overnight to afford 65.5 g of the target compound 3-cyano-6-methyl-pyridone (61.0% yield) as a yellow solid.

References

[1] Patent: CN105037261, 2017, B. Location in patent: Paragraph 0048-0049
[2] Molecules, 2018, vol. 23, # 7,
[3] Patent: US6342504, 2002, B1. Location in patent: Page column 50
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3303 - 3312
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 6, p. 2212 - 2215

3-Cyano-6-methyl-2(1H)-pyridinone Preparation Products And Raw materials

Raw materials

Acetone Ethyl formate Piperidine Sodium Methoxide Diethyl ether 2-Cyanoacetamide Acetic acid

Preparation Products

Less

3-Cyano-6-methyl-2(1H)-pyridinone Suppliers

Americas 1 Belgium 2 Canada 1 China 170 Europe 1 France 1 Germany 6 India 18 Japan 4 Switzerland 2 The Netherlands 3 Ukraine 1 United Kingdom 12 United States 27 Global 249

Shandong Jiayi New material Technology Co., LTD

Tel: +86-15275165458 +86-15275165458
Email: 717168503@qq.com
Country: China
ProdList: 8
Advantage: 58

Hubei Guanzhongtong Technology Co.,LTD

Tel: 0716-7227299 13507251920
Fax: 0716-7227299
Email: finecq@163.com
Country: China
ProdList: 34
Advantage: 58

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376080562
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 884
Advantage: 60

Shanghai Dingshi Pharmaceutical Technology Co., Ltd

Tel: 15921634331
Email: 1509836518@qq.com
Country: China
ProdList: 120
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Shanghai Feibo Chemical Technology Co., Ltd

Tel: 021-58955608,2250286 15921236618
Email: blinkzeng@gmail.com
Country: China
ProdList: 522
Advantage: 62

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
Email: chibapharm@foxmail.com
Country: China
ProdList: 3992
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: 021-02136680027 15800370750
Email: 1706640024@qq.com
Country: China
ProdList: 570
Advantage: 56

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Chimica Laboratories Co., Ltd

Tel: 0086-573-82585213
Fax: 0086-573-82585233
Email: bai@chimicalabs.com
Country: China
ProdList: 861
Advantage: 64

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Chengdu Laurelsci Tech Co., Ltd.

Tel: 028-87983001
Fax: +86-28-86102331
Email: sales@laurelsci.com
Country: China
ProdList: 50
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

Giant chemicals

Tel: 028-85434334 18108076537
Fax: QQ：245797092
Email: market@gianthx.com
Country: China
ProdList: 4505
Advantage: 56

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Less

View Lastest Price from 3-Cyano-6-methyl-2(1H)-pyridinone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Cyano-6-methyl-2(1H)-pyridinone 4241-27-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Cyano-6-Methyl-2-Pyridone 4241-27-4
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Cyano-6-Methyl-quinolin-2(1H)-one 4241-27-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

4241-27-4, 3-Cyano-6-methyl-2(1H)-pyridinoneRelated Search:

Methyl acetate Bensulfuron methyl 2-Chloro-3-cyanopyridine 3-Cyanopyridine 2-Chloro-5-chloromethylpyridine Kresoxim-methyl 2,4,6-Collidine Trimethylsilyl cyanide CHLOROPHOSPHONAZO III Methylparaben 4-Methylpyridine Methyl acrylate 2,6-Lutidine Azamethiphos METSULFURON METHYL Thiophanate-methyl Methyl Methyl bromide

Nicotinonitrile, 1,2-dihydro-6-methyl-2-oxo- (8CI)

2-keto-6-methyl-1H-pyridine-3-carbonitrile

NSC 15124

5-Cyano-6-hydroxy-2-picoline 3-Cyano-6-methyl-2-pyridinol 2-Hydroxy-6-methylnicotinonitrile

Nicotinonitrile, 1,2-dihydro-6-Methyl-2-oxo-

3-Cyano-6-methyl-2(1<i>H</i>)-pyridinone

3-Cyano-6-methyl-2-pyridone,98%

1,2-DIHYDRO-6-METHYL-2-OXO-3-PYRIDINECARBONITRILE

1,2-dihydro-6-methyl-2-oxonicotinonitrile

3-CYANO-6-METHYL-2(1H)-PYRIDINONE

3-CYANO-6-METHYL-2-PYRIDONE

3-CYANO-2-HYDROXY-6-METHYLPYRIDINE

6-METHYL-3-CYANO-2-PYRIDONE

6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE

2-HYDROXY-6-METHYLNICOTINONITRILE

2-HYDROXY-6-METHYLPYRIDINE-3-CARBONITRILE

5-cyano-6-hydroxy-2-picoline

1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitril

3-cyano-6-methyl-2(1h)-pyridone

3-CYANO-6-METHYL-2(1H)-PYRIDINONE 96%

3-Cyano-6-methyl-2-pyridinol

3-Pyridinecarbonitrile, 1,2-dihydro-6-methyl-2-oxo-

6-Methyl-2-oxo-1H-pyridine-3-carbonitrile

3-Cyano-6-methyl-2(1h)-pyridinone ,98%

1,2-Dihydro-2-oxo-6-methylpyridine-3-carbonitrile

2-Oxo-6-methyl-1,2-dihydro-3-pyridinecarbonitrile

3-Cyano-6-methyl-2(1H)-pyridinone,96%

6-Methyl-3-cyanopyridin-2ol

3-Cyano-6-Methyl-quinolin-2(1H)-one

3-Cyano-6-methyl3-Cyano-6-methyl-2(1H)-pyridinone-2(1H)-pyridinone

3-Cyano-6-methyl-2-pyridone &gt

3-Cyano-6-methyl-2(1H)-pyridinone ISO 9001：2015 REACH

3-cyano-6-methyl-2(H)pyridinone

6-Methyl-4-(methylthio)-2-oxo-2,3-dihydropyridine-3-carbonitrile

1,2-Dihydro-6-methyl-2-oxo-pyridin-3-carbonitrile

4241-27-4

Heterocyclic Building Blocks

Pyridines

Building Blocks

C7 and C8

cyanide|alcohol

Building Blocks

C6 to C7

Chemical Synthesis

Heterocyclic Building Blocks

Pyridines

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles

Pyridine