Capillarisin
- Product Name
- Capillarisin
- CAS No.
- 56365-38-9
- Chemical Name
- Capillarisin
- Synonyms
- Capillaris;CAPILLARISIN;CAPILLARISIN(RG);CAPILLARISIN hplc;Capillarisin std.;Capillarisin Standard;Capillarisin USP/EP/BP;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one;5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-1-benzopyran-4-one
- CBNumber
- CB7693122
- Molecular Formula
- C16H12O7
- Formula Weight
- 316.26
- MOL File
- 56365-38-9.mol
Capillarisin Property
- Melting point:
- approximate 225℃ (dec.)
- Boiling point:
- 582.6±50.0 °C(Predicted)
- Density
- 1.551±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 6.37±0.40(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CHM0013960
- Product name
- CAPILLARISIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.42
- Updated
- 2021/12/16
- Product number
- MT-04373
- Product name
- Capillarisin
- Purity
- 98%
- Packaging
- 0.025g
- Price
- $336
- Updated
- 2021/12/16
- Product number
- CFN90317
- Product name
- Capillarisin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $468
- Updated
- 2021/12/16
Capillarisin Chemical Properties,Usage,Production
Uses
Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].
Definition
ChEBI: Capillarisin is a member of coumarins.
in vivo
Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4].
| Animal Model: | ICR mice[4] |
| Dosage: | 20 and 80 mg/kg |
| Administration: | I.p.; 1 hour |
| Result: | Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2). |
target
TLR | NF-kB | MAPK | STAT | TNF-α | IL Receptor | NO | PGE | AP-1 | ERK | NOS | COX | MMP(e.g.TIMP) | VEGFR | JNK | Bcl-2/Bax
References
[1] Peng G, et al. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pak J Pharm Sci. 2020;33(4(Supplementary)):1907-1915. PMID:33612476
[2] Komiya T, et al. Capillarisin, a Constituent from Artemisiae Capillaris Herba. Chemical and Pharmaceutical Bulletin, 1975
[3] Zhao T, Wang Q. Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Life Sci. 2020;259:118279. DOI:10.1016/j.lfs.2020.118279
[4] Khan S, et al. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol. 2014;152(3):478-486. DOI:10.1016/j.jep.2014.01.028
Capillarisin Preparation Products And Raw materials
Raw materials
Preparation Products
Capillarisin Suppliers
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