3,4-(Methylenedioxy)aniline
- Product Name
- 3,4-(Methylenedioxy)aniline
- CAS No.
- 14268-66-7
- Chemical Name
- 3,4-(Methylenedioxy)aniline
- Synonyms
- benzo[d][1,3]dioxol-5-amine;1,3-BENZODIOXOL-5-AMINE;enedioxy)aniL;AKOS BBS-00004239;5-Aminobenzodioxole;Methylenedioxyaniline;Paroxetine Impurity 62;5-Amino-1,3-benzodioxo;4-aMino-1,3-benzodioxole;3,4-Methylendioxyaniline
- CBNumber
- CB7695555
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 14268-66-7.mol
3,4-(Methylenedioxy)aniline Property
- Melting point:
- 39-41 °C(lit.)
- Boiling point:
- 144 °C16 mm Hg(lit.)
- Density
- 1.2528 (rough estimate)
- refractive index
- 1.5030 (estimate)
- Flash point:
- 289 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.78±0.20(Predicted)
- form
- Low Melting Solid
- color
- Dark brown to black
- Water Solubility
- slightly soluble
- Sensitive
- Air & Light Sensitive
- BRN
- 4919
- CAS DataBase Reference
- 14268-66-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,3-Benzodioxol-5-amine(14268-66-7)
- EPA Substance Registry System
- 1,3-Benzodioxol-5-amine (14268-66-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 161497
- Product name
- 3,4-(Methylenedioxy)aniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 161497
- Product name
- 3,4-(Methylenedioxy)aniline
- Purity
- 97%
- Packaging
- 50g
- Price
- $137
- Updated
- 2024/03/01
- Product number
- M0741
- Product name
- 3,4-Methylenedioxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $73
- Updated
- 2024/03/01
- Product number
- M0741
- Product name
- 3,4-Methylenedioxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $218
- Updated
- 2024/03/01
- Product number
- A12975
- Product name
- 3,4-(Methylenedioxy)aniline, 98+%
- Packaging
- 10g
- Price
- $30.65
- Updated
- 2024/03/01
3,4-(Methylenedioxy)aniline Chemical Properties,Usage,Production
Chemical Properties
dark brown to black low melting solid
Uses
3,4-(Methylenedioxy)aniline is an pharmaceutically important aniline derivative. It undergoes N-alkylation with cyclic secondary alkylamines in the presence of Shvo catalyst to yield N-arylpyrrolidines. 3,4-(Methylenedioxy)aniline was used in the synthesis of γ-glutamylanilides.
Synthesis
A 10mL-sealed tube was charged with 5-bromobenzo[d][1,3]dioxole (1mmol), CuI (19mg, 0.1mmol), and DMEDA (13mg/16μL, 0.15mmol) in NH4OH (1.5mL, 27% NH3 in H2O) and DMSO (0.5mL). The tube was flushed with Ar gas before being capped. The solution was stirred at 130°C or 110°C for the given times. The resulting suspension was cooled to room temperature, and saturated aqueous Na2SO4 solution (5mL) was added. The resulting solution was extracted with EtOAc (20mL×3). The organic layer was separated, dried over MgSO4, filtered, and concentrated. The residue was purified by flash column chromatography to give 3,4-(Methylenedioxy)aniline.
Purification Methods
Crystallise the base from pet ether and/or distil it in a vacuum. The hydrochloride has m 198o(dec). [Sonn & Benirschke Chem Ber 54 1734 1921, Beilstein 19 H 328, 19 II 341, 19 III/IV 4056.]
3,4-(Methylenedioxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-(Methylenedioxy)aniline manufacturers
- Product
- 3,4-(Methylenedioxy)aniline 14268-66-7
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2022-12-06
- Product
- 3,4-(Methylenedioxy)aniline 14268-66-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- as request
- Release date
- 2018-12-23