ChemicalBook > CAS DataBase List > L-Alanine methyl ester hydrochloride

L-Alanine methyl ester hydrochloride

Product Name
L-Alanine methyl ester hydrochloride
CAS No.
2491-20-5
Chemical Name
L-Alanine methyl ester hydrochloride
Synonyms
ALANINE METHYL ESTER HYDROCHLORIDE;ALA-OME.HCL;ALANINE-OME HCL;METHYL L-ALANINATE HYDROCHLORIDE;L-Ala-OMe.HCL;(S)-Methyl 2-aMinopropanoate hydrochloride;L-alanina;anine methyL;H-ALA-OME HCL;A-Ala-OMe·HCl
CBNumber
CB7715055
Molecular Formula
C4H10ClNO2
Formula Weight
139.58
MOL File
2491-20-5.mol
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L-Alanine methyl ester hydrochloride Property

Melting point:
109-111 °C(lit.)
alpha 
7 º (c=2, CH3OH 24 ºC)
refractive index 
6.5 ° (C=2, MeOH)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Powder
color 
White to off-white
optical activity
[α]25/D +7.0°, c = 1.6 in methanol
Water Solubility 
Soluble in Water (100 mg/ml).
Sensitive 
Hygroscopic
BRN 
3594033
InChI
InChI=1/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H/t3-;/s3
InChIKey
IYUKFAFDFHZKPI-OQFXAWDINA-N
SMILES
C(=O)(OC)[C@@H](N)C.Cl |&1:4,r|
CAS DataBase Reference
2491-20-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
330639
Product name
L-Alanine methyl ester hydrochloride
Purity
99%
Packaging
5g
Price
$39.7
Updated
2025/07/31
Sigma-Aldrich
Product number
330639
Product name
L-Alanine methyl ester hydrochloride
Purity
99%
Packaging
25g
Price
$115
Updated
2025/07/31
Sigma-Aldrich
Product number
S378909
Product name
ALANINE METHYL ESTER HYDROCHLORIDE
Purity
AldrichCPR
Packaging
250MG
Price
$159
Updated
2022/05/15
TCI Chemical
Product number
A1466
Product name
L-Alanine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
A1466
Product name
L-Alanine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$85
Updated
2025/07/31
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L-Alanine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

L-Alanine methyl ester hydrochloride is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

56-41-7

2491-20-5

The general procedure for the synthesis of (S)-alanine methyl ester hydrochloride (1a) from methanol and L-alanine was as follows: 15 mL of anhydrous methanol was first added to a round-bottomed flask according to the literature (Xing et al., 2012). At -15 °C, 2.16 mL of SOCl2 (0.03 mol) was slowly added dropwise to methanol and the reaction was maintained at 0 °C for 1 hour. Another round bottom flask was taken and 14 mL of anhydrous methanol and 1.4 mL (0.019 mol) of SOCl2 was added followed by 1.118 g of L-alanine and heated to reflux for 1.5 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure, and the pre-prepared SOCl2 solution was poured into the reaction flask and refluxing was continued for 1.5 h to give product 1a (100% yield). Since the hydrochloric acid generated by the reaction was not favorable for the subsequent steps, NaHCO3 was added to the reaction flask at the end of reflux to neutralize the acidity until no bubbles were generated. Finally, the solution was concentrated to obtain 1b (100% yield). Fusaric acid (4) was dissolved with 1b in 15 mL of dichloromethane in a round-bottomed flask with homogeneous stirring, followed by the addition of excess catalysts dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), and refluxed for 24 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by preparative HPLC (25-45% CH3CN/H2O, 20 min) to afford the product 1c (52% yield).

References

[1] Phytochemistry Letters, 2018, vol. 26, p. 50 - 54
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 36, p. 11683 - 11687
[3] Angew. Chem., 2018, vol. 130, # 36, p. 11857 - 11861,5
[4] Journal of Organic Chemistry, 2008, vol. 73, # 7, p. 2898 - 2901
[5] Tetrahedron Asymmetry, 2009, vol. 20, # 9, p. 1036 - 1039

L-Alanine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-Alanine methyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Ala-Ome.Hcl 2491-20-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-22
Henan Aochuang Chemical Co.,Ltd.
Product
L-Alanine methyl ester hydrochloride 2491-20-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-27
Wuhan Boyuan Import & Export Co., LTD
Product
L-Alanine methyl ester hydrochloride 2491-20-5
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000ton
Release date
2023-08-15

2491-20-5, L-Alanine methyl ester hydrochlorideRelated Search:

Kresoxim-methyl Paraquat dichloride Methylphenidate hydrochloride L-Alanine D-Alanine EC 2.6.1.2 Phenprobamate Methylparaben Topotecan hydrochloride Acetonitrile Methyl acrylate Basic Violet 1 Methanol Methyl rac-Tenofovir-d7 Chloromethyl isopropyl carbonate ChloroMethyl Propyl Carbonate (S)-Tenofovir

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