Hydrocinnamoyl chloride

Product Name: Hydrocinnamoyl chloride
CAS No.: 645-45-4
Chemical Name: Hydrocinnamoyl chloride
Synonyms: 3-PHENYLPROPANOYL CHLORIDE;HCC;BENZENEPROPANOYL CHLORIDE;3-PHENYLPROPIONYL CHLORIDE;HLD5;FAM126A;SKL1316;DRCTNNB1A;Hydrocinnamoyl;3-Phenylpropionyl ch
CBNumber: CB7731088
Molecular Formula: C9H9ClO
Formula Weight: 168.62
MOL File: 645-45-4.mol

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Hydrocinnamoyl chloride Property

Melting point:: −7-−5 °C(lit.)
Boiling point:: 107 °C11 mm Hg(lit.)
Density: 1.135 g/mL at 25 °C(lit.)
vapor pressure: 6.893Pa at 25℃
refractive index: n20/D 1.5265(lit.)
Flash point:: 227 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly)
form: Liquid
color: deep greenish-yellow
Water Solubility: Soluble in water (reacts), and ether.
Sensitive: Moisture Sensitive
BRN: 742586
LogP: 1.73
CAS DataBase Reference: 645-45-4(CAS DataBase Reference)
NIST Chemistry Reference: Benzenepropanoyl chloride(645-45-4)
EPA Substance Registry System: Benzenepropanoyl chloride (645-45-4)

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Safety

Hazard Codes: C
Risk Statements: 20-34-29-14
Safety Statements: 26-36/37/39-45-8-30-23
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
RTECS: MW5652395
F: 10-21
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29163900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H331Toxic if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 249440
Product name: Hydrocinnamoyl chloride
Purity: 98%
Packaging: 5g
Price: $33.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 249440
Product name: Hydrocinnamoyl chloride
Purity: 98%
Packaging: 25g
Price: $86.5
Updated: 2025/07/31

TCI Chemical

Product number: H0696
Product name: 3-Phenylpropionyl Chloride
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $74
Updated: 2025/07/31

TRC

Product number: P336215
Product name: 3-Phenylpropionyl Chloride
Packaging: 50g
Price: $110
Updated: 2021/12/16

Oakwood

Product number: 448612
Product name: 3-Phenylpropanoylchloride
Purity: 98%
Packaging: 5g
Price: $15
Updated: 2021/12/16

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Hydrocinnamoyl chloride Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.

Uses

Hydrocinnamoyl chloride has been used in:

enantioselective synthesis of the antifouling agent, (+)-maculalactone A
synthesis of hydrocinnamoyl-farnesyl-L-cysteine methyl ester

Uses

Hydrocinnamoyl chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.

General Description

Reduction of hydrocinnamoyl chloride at mercury cathodes in acetonitrile containing tetraalkylammonium perchlorates has been investigated by cyclic voltammetry.

Flammability and Explosibility

Not classified

Synthesis

501-52-0

645-45-4

General procedure for the synthesis of hydrocinnamoyl chloride from hydrogenated cinnamic acid: To a 200 mL flask equipped with a stir bar and an argon inlet septum were added hydrogenated cinnamic acid (5.00 g, 33.3 mmol), N,N-dimethylformamide (DMF, 0.1 mL), and dichloromethane (CH2Cl2, 30 mL). Oxalyl chloride ((COCl)2, 2 M in CH2Cl2, 20.0 mL, 40.0 mmol) was slowly added to the resulting solution over 30 min. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by vacuum concentration to afford 3-phenylpropionyl chloride (74, 5.9 g, yellow oil) in 100% yield. The purity of the product was confirmed to be 99% by high performance liquid chromatography (HPLC) analysis (mobile phase ratio: water:acetonitrile:methanol = 15:10:75) with a retention time of 5.3 min.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 10, p. 2899 - 2903
[2] Patent: WO2013/101911, 2013, A2. Location in patent: Page/Page column 57
[3] Arkivoc, 2018, vol. 2018, # 5, p. 334 - 347
[4] Advanced Synthesis and Catalysis, 2015, vol. 357, # 18, p. 3825 - 3830
[5] Journal of the American Chemical Society, 1980, vol. 102, # 20, p. 6311 - 6314

Hydrocinnamoyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydrocinnamoyl chloride Suppliers

Americas 1 Belgium 3 Canada 3 China 260 Europe 3 France 3 Germany 10 India 23 Italy 1 Japan 7 Slovakia 1 Switzerland 4 Ukraine 2 United Kingdom 16 United States 58 Global 396

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View Lastest Price from Hydrocinnamoyl chloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Hydrocinnamoyl chloride 645-45-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

R&D Scientific Inc.

Product: 3-Phenylpropionyl Chloride 645-45-4
Price: US $550.00/Kg
Min. Order: 0.100Kg
Purity: 99
Supply Ability: 1000 Kg
Release date: 2024-10-03

Henan Fengda Chemical Co., Ltd

Product: Hydrocinnamoyl chloride 645-45-4
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-24

645-45-4, Hydrocinnamoyl chlorideRelated Search:

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Hydrocinnamoyl chloride ISO 9001：2015 REACH

SKL1316

TIANFU-CHEM Hydrocinnamoyl chloride

645-45-4

15761-37-4

C6H5CH22COCl

C6H5CH2CH2COCl

Organic Building Blocks

Acid Halides

Building Blocks

Carbonyl Compounds

ACID CHLORIDE

Pyridines

Aromatic Halides (substituted)

ACID CHLORIDES

Pharmaceutical Intermediates

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