trans-Chalcone Property

Melting point:

55-59 °C

Boiling point:

208 °C25 mm Hg(lit.)

Density 

1.0712

refractive index 

1.5361 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly)

form 

Solid

color 

Pale Yellow

Odor

at 100.00 %. floral balsam herbal

Odor Type

floral

Water Solubility 

Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water.

Merck 

14,2037

BRN 

509985

LogP

4.013 (est)

CAS DataBase Reference

614-47-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzalacetophenone(614-47-1)

Safety

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37

Safety Statements 

22-36/37/39-45

WGK Germany 

3

RTECS 

UD5576750

HS Code 

29143990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

trans-Chalcone Chemical Properties,Usage,Production

Description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Chemical Properties

Trans-Chalcone is a yellowish crystals. M.P. 58℃. (trans-isomer). M .P. 46℃. (cis-isomer).Sp.Gr. 1.07 (liquid).Insoluble in water, soluble in alcohol (poorly) and oils.

Uses

trans-Chalcone is a positive allosteric modulator of α7 nicotinic acetylcholine receptors and exhibits antioxidant activity.

Definition

ChEBI: Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. It has a role as a plant metabolite. It is a member of styrenes and a member of chalcones.

Application

trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).

Preparation

trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Clay-catalysed solventless synthesis of trans-chalcones

Synthesis Reference(s)

Journal of the American Chemical Society, 104, p. 4724, 1982 DOI: 10.1021/ja00381a058

General Description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Biological Activity

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Biochem/physiol Actions

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Synthesis

Trans-Chalcone is synthesized by condensation of Benzaldehyde with Acetophenone.