ChemicalBook > CAS DataBase List > Ethyl dimethylphosphonoacetate
Ethyl dimethylphosphonoacetate
- Product Name
- Ethyl dimethylphosphonoacetate
- CAS No.
- 311-46-6
- Chemical Name
- Ethyl dimethylphosphonoacetate
- Synonyms
- Ethyl 2-(dimethoxyphosphoryl);DimethylEthylphosphonoacetate;ETHYL DIMETHYLPHOSPHONOACETATE;EthylDimethylphosphonoacetate>Dimethyl ethyl phosphonylacetate;ethyl 2-dimethoxyphosphorylacetate;ETHYL DIMETHYLPHOSPHONOACETATE 98%;ethyl (dimethoxyphosphinoyl)acetate;ethyl 2-dimethoxyphosphorylethanoate;Ethyl 2-(dimethoxyphosphinyl)acetate
- CBNumber
- CB7747548
- Molecular Formula
- C6H13O5P
- Formula Weight
- 196.14
- MOL File
- 311-46-6.mol
More
Less
Ethyl dimethylphosphonoacetate Property
- Boiling point:
- 134 °C10 mm Hg(lit.)
- Density
- 1.188 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.435(lit.)
- Flash point:
- 99 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Almost colorless
- BRN
- 1777603
- InChI
- InChI=1S/C6H13O5P/c1-4-11-6(7)5-12(8,9-2)10-3/h4-5H2,1-3H3
- InChIKey
- HUNISAHOCCASGM-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)CP(OC)(OC)=O
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 02610
- Product name
- Ethyl dimethylphosphonoacetate
- Purity
- technical, ≥90% (GC)
- Packaging
- 10ml
- Price
- $103
- Updated
- 2023/06/20
TCI Chemical
- Product number
- E1160
- Product name
- Ethyl Dimethylphosphonoacetate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $50
- Updated
- 2025/07/31
TRC
- Product number
- E917443
- Product name
- Ethyl Dimethylphosphonoacetate
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
AK Scientific
- Product number
- O302
- Product name
- Ethyl Dimethylphosphonoacetate
- Packaging
- 100g
- Price
- $90
- Updated
- 2021/12/16
Ark Pharm
- Product number
- AK113540
- Product name
- Ethyl2-(dimethoxyphosphoryl)acetate
- Purity
- 97%
- Packaging
- 500g
- Price
- $97
- Updated
- 2021/12/16
More
Less
Ethyl dimethylphosphonoacetate Chemical Properties,Usage,Production
Uses
Reactant for synthesis of:
- Non-nucleoside inhibitors of HCV polymerase NS5B
- Neuropeptide Y1 receptor antagonists
- Alkenylcarboxylates from Horner-Wadsworth-Emmons reactions
Reactant for:
- Enantioselective transfer hydrogenation for preparation of the C7-C14 fragment of ulapualide A
- Intramolecular Michael reactions
- Olefination of peptidyl aldehydes with stabilized ylides
Application
Ethyl dimethylphosphonoacetate could prepare a temporary plugging agent with hydroxyethylpyrrolidone and ethyl perfluorobutyl ether. The temporary plugging agent is useful for oil-water wells.
reaction suitability
reaction type: C-C Bond Formation
Synthesis
105-39-5
121-45-9
311-46-6
The general procedure for the synthesis of ethyl dimethylphosphonoacetate from ethyl chloroacetate and trimethoxyphosphorus is as follows: a dry and clean 500 mL coil was heated to 150 °C. Take 1000g (0.7 eq., 8.16 mol) of ethyl chloroacetate (boiling point 142~145°C at standard atmospheric pressure) in reaction flask A and dilute it by adding 4000g of toluene. Another 1417g (1.0 eq., 11.42mol) of trimethoxyphosphine (boiling point at 112°C under standard atmospheric pressure) was placed in reaction vial B, and 3583g of toluene was added for dilution. After the coil temperature was stabilized, pump A (mixed solution of ethyl chloroacetate and toluene) and pump B (mixed solution of trimethoxyphosphine and toluene) were activated, both at a flow rate of 25.0 g/min. The residence time of the reactants in the reactor was 10 min, and the reaction pressure was maintained at 0.5~2.0 MPa. Upon completion of the reaction, the discharge port was directly connected to the thin-film evaporation device, and the evaporation pressure was controlled to 4~ 10×102 Pa, and the temperature was 95~105°C. Finally, 1344 g of ethyl dimethylphosphonoacetate (boiling point of 110~112°C, 466 Pa) was obtained with a yield of 84%.
References
[1] Patent: CN107163079, 2017, A. Location in patent: Paragraph 0068; 0069; 0070; 0071
[2] Bulletin de la Societe Chimique de France, 1965, p. 1925 - 1930
[3] Tetrahedron Letters, 1999, vol. 40, # 8, p. 1455 - 1458
Ethyl dimethylphosphonoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Ethyl dimethylphosphonoacetate Suppliers
- Tel
- 15888611133; 13566409786;18605760166
- trade@jxswchem.com
- Country
- China
- ProdList
- 15
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-021-57872719 13761402923
- Fax
- 02157872719
- 245662540@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 60
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 86-13605431940 13605431940
- Fax
- 0086-0543-2240079
- zpmxchemical@126.com
- Country
- China
- ProdList
- 1490
- Advantage
- 62
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4942
- Advantage
- 58
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 0570-8789886 18892685668
- Fax
- 0570-8789985
- info@rundongchemical.com
- Country
- China
- ProdList
- 4053
- Advantage
- 60
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9021
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 18221735425
- sales@xinpingchem.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-34053660
- Fax
- QQ:2881074831
- sale2@labgogo.com
- Country
- China
- ProdList
- 2018
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 021-37581181
- Fax
- 021-57456066
- sales@chem-mall.com
- Country
- China
- ProdList
- 10330
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 0570-3062289 13819008176 15068926975
- Fax
- 0570-3063388
- 527757556@qq.com
- Country
- China
- ProdList
- 2957
- Advantage
- 58
- Tel
- 400-6387771-6039 18920764717
- sales@heowns.com
- Country
- China
- ProdList
- 23771
- Advantage
- 60
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9988
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 021-54252912-8903
- leona.xin@forneeds.cn
- Country
- China
- ProdList
- 4759
- Advantage
- 58
- Tel
- 0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- 0519-85859058 13915836899
- 2078957504@qq.com
- Country
- China
- ProdList
- 358
- Advantage
- 58
- Tel
- 021-67121386, 800-988-0390
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 5391
- Advantage
- 58
- Tel
- 027-83855389 13545340383
- Fax
- 027-83855389
- 2586905842@qq.com
- Country
- China
- ProdList
- 998
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 11784
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34563
- Advantage
- 58
- Tel
- +8613761402923
- sales@modeltemol.com
- Country
- CHINA
- ProdList
- 571
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- +8615986615575
- Fax
- 0086-13651442114
- info@codchem.com
- Country
- China
- ProdList
- 20342
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- +86-5922680277 +86-13806087780
- sale@simagchem.com
- Country
- China
- ProdList
- 17346
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
More
Less
View Lastest Price from Ethyl dimethylphosphonoacetate manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- Ethyl dimethylphosphonoacetate 311-46-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
Career Henan Chemical Co
- Product
- Ethyl dimethylphosphonoacetate 311-46-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30
311-46-6, Ethyl dimethylphosphonoacetateRelated Search:
Dimethyl adipate
Dimethyl terephthalate
Ethylparaben
Dimethyl ether
Dimethyl carbonate
Dimethyl sulfate
ISOXADIFEN-ETHYL
ETHANE
Ethyl acetate
Ethyl acrylate
Ethyl cyanoacetate
Dimethyl malonate
Dimethyl phosphite
Dimethyl sulfoxide
Dimethyl fumarate
Dimethyl phthalate
Ethyl oleate
Ethyl pyruvate