SKF 96365 HYDROCHLORIDE

Product Name: SKF 96365 HYDROCHLORIDE
CAS No.: 130495-35-1
Chemical Name: SKF 96365 HYDROCHLORIDE
Synonyms: CS-2170;SKF 96365;SKF 96365 HCI;SKF-96365, HC;SKF-96365, HCl;SK AND F 96365;SKF-96365;SKF 96365;SKF 96365 hydrochlor;SKF 96365 HYDROCHLORIDE;SKF 96365, TRP channel blocker
CBNumber: CB7752278
Molecular Formula: C22H27ClN2O3
Formula Weight: 402.91
MOL File: 130495-35-1.mol

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SKF 96365 HYDROCHLORIDE Property

Melting point:: 119 °C
RTECS: NI6823500
storage temp.: Inert atmosphere,Room Temperature
solubility: H₂O: >20 mg/mL
form: solid
color: white
Water Solubility: Soluble to 100mM in water
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 130495-35-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933.29.4300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7809
Product name: SKF-96365
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $214
Updated: 2024/03/01

TCI Chemical

Product number: K0066
Product name: SKF-96365
Packaging: 10MG
Price: $223
Updated: 2024/03/01

TCI Chemical

Product number: K0066
Product name: SKF-96365
Packaging: 50MG
Price: $365
Updated: 2024/03/01

Alfa Aesar

Product number: J60937
Product name: SKF-96365 hydrochloride, 99+%
Packaging: 10mg
Price: $380
Updated: 2023/06/20

Alfa Aesar

Product number: J60937
Product name: SKF-96365 hydrochloride, 99+%
Packaging: 50mg
Price: $0
Updated: 2021/12/16

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SKF 96365 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

SKF-96365 (130495-35-1) is an inhibitor of receptor-mediated calcium entry (RMCE) with IC50‘s of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca2+ but not ATP-gated Ca2+ entry.1 It has also been shown to block transient receptor potential canonical type (TRPC) channels2, high-voltage-activated (HVA) L-type channels1, K channels3, sarcoplasmic reticulum Ca-ATPase4 and voltage-gated sodium channels5. SKF-96365 is a potent blocker of LVA T-type Ca channels, in particular Ca(V)3.1 (IC50 = 0.56 μM).6

Uses

SKF 96365 Hydrochloride is a novel inhibitor of receptor-mediated calcium entry.

Definition

ChEBI: SKF-96365 hydrochloride is the hydrochloride salt of SKF-96365. It is a TRP channel blocker. It has a role as a TRP channel blocker, an apoptosis inducer, an autophagy inducer, a GABA antagonist, an antineoplastic agent, a calcium channel blocker and a platelet aggregation inhibitor. It contains a SKF-96365 free base(1+).

General Description

Inhibits receptor-mediated Ca²⁺ entry in stimulated platelets (IC₅₀ = 8-12 μM in intact platelets), neutrophils, and endothelial cells (IC₅₀ = 30 μM for human endothelial cells) at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Biological Activity

Store-operated Ca 2+ entry (SOCE) inhibitor that inhibits STIM1. Also inhibits TRP channels, voltage-gated Ca 2+ channels and potassium channels.

Biochem/physiol Actions

SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca2+?entry and voltage-gated Ca2+?entry . SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization. It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression. SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.

storage

Store at RT

References

1) Merritt et al.,(1990) SKF96365, a novel inhibitor of receptor-mediated calcium entry; Biochem. J. 271 515 2) Kiselyov et al., (1998) Functional interaction between InsP3 receptors and store-operated Htrp3 channels; Nature, 396 478 3) Schwarz et al., (1994) Multiple effects of SKF96365 on ionic currents and intracellular calcium in human endothelial cells; Cell Calcium, 15 45 4) Mason et al., (1993) Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole and SKF96365; Am. J. Physiol., 264 C654 5) Hong et al. (1994) Inhibition of the sodium channel by SKF96365, an inhibitor of the receptor-operated calcium channel, in mouse diaphragm; J. Biomed. Sci., 1 172 6) Singh et al.,(2010) The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels; Br. J. Pharmacol., 160 1464

SKF 96365 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SKF 96365 HYDROCHLORIDE Suppliers

Americas 1 China 85 Europe 1 Germany 2 India 2 Japan 3 South Korea 1 Switzerland 2 United Kingdom 4 United States 21 Global 122

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130495-35-1, SKF 96365 HYDROCHLORIDERelated Search:

(+/-)-BAY K 8644 Vanoxerine dihydrochloride AFC Nicardipine hydrochloride Octyl 4-methoxycinnamate Cinnamyl alcohol 4-Methoxyphenol Methoxyacetic acid 4-Methoxybenzoic acid MSK-195 L-Menthol IMIDAZOLE HYDROCHLORIDE 1-Phenyl-2-(1-imidazolyl)ethanol SKF 96365 HYDROCHLORIDE 2-HYDROXY-2-(4-METHOXYPHENYL)ETHYLAMINE HYDROCHLORIDE

1-[BETA-[3-(4-METHOXYPHENYL)PROPOXY]-4-METHOXYPHENETHYL]-1H-IMIDAZOLE HCL

1-(BETA-[3-(4-METHOXYPHENYL)PROPOXY]-4-METHOXYPHENETHYL)-1H-IMIDAZOLE HYDROCHLORIDE

1-[2-(4-METHOXYPHENYL)-2-[3-(4-METHOXYPHENYL)PROPOXY]ETHYL]-1H-IMIDAZOLE HYDROCHLORIDE

SK AND F 96365

SKF 96365

SKF 96365 HYDROCHLORIDE

SKF-96365, HCl

1-[β-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenethyl]-1h-imidazole hydrochloride

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole

SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem

SKF-96365;SKF 96365

CS-2170

1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole

1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride

1H-Imidazole, 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-, monohydrochloride

SKF 96365 HCI

1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole monohydrochloride

SKF-96365, HC

SKF 96365 hydrochlor

SKF 96365, TRP channel blocker

130495-35-1

C22H26N2O3HCl

Voltage-gated Ion Channels

Ion Channels

Inhibitors and Activators

Cell Signaling and Neuroscience

Cell Biology

Calcium Channel Modulators

BioChemical

Calcium channel

Signalling