Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate
- Product Name
- Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate
- CAS No.
- 20187-46-6
- Chemical Name
- Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate
- Synonyms
- 5-CARBETHOXYCYTOSINE;RSYY（Donepezil Hydrochloride)-12;2-hydroxy-4-amino-5-ethoxycarbonyl-pyrimidine;Ethyl4-Amino-2-hydroxy-5-pyrimidinecarboxylate;ethyl 6-amino-2-oxo-1H-pyrimidine-5-carboxylate;ETHYL-4-AMINO-2-HYDROXY PYRIMIDINE-5-CARBOXYLATE;Ethyl 4-aMino-2-hydroxypyriMidine-5-carboxyla...;ethyl 6-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylate;4-AMino-2-hydroxy-pyriMidine-5-carboxylic acid ethyl ester;5-pyriMidinecarboxylic acid, 4-aMino-2-hydroxy-, ethyl ester
- CBNumber
- CB7756241
- Molecular Formula
- C7H9N3O3
- Formula Weight
- 183.16
- MOL File
- 20187-46-6.mol
Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate Property
- Melting point:
- 276 °C (decomp)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.91±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- S343374
- Product name
- 5-CARBETHOXYCYTOSINE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- E678635
- Product name
- EthylCytosine-5-carboxylate
- Packaging
- 500mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- W4263
- Product name
- Ethyl4-amino-2-hydroxypyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $487
- Updated
- 2021/12/16
- Product number
- NUC0001669
- Product name
- 6-AMINO-2-OXO-1,2-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.9
- Updated
- 2021/12/16
- Product number
- SC-23695
- Product name
- 2-hydroxy-4-amino-5-ethoxycarbonyl-pyrimidine
- Purity
- 95
- Packaging
- 1g
- Price
- $583
- Updated
- 2021/12/16
Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl Cytosine-5-carboxylate is a reagent for the synthesis of cytidine-5-carboxylic acid, which are potential anticancer agents.
Synthesis
61679-83-2
20187-46-6
General procedure for the synthesis of ethyl 2-hydroxy-4-aminopyrimidine-5-carboxylate from RSSYY (lurasidone hydrochloride)-16: 400 ml of diethyl ether and 500 ml of tetrahydrofuran were added to a 2500 ml round bottomed flask, followed by the addition of 30 ml of sodium tert-butanol to synthesize intermediate 2. After stirring the mixture, 183 g (1 mol) of intermediate 1 and (0.1 mol) of sodium magnesium oxide nanopowder. The reaction mixture was heated to 75°C and maintained at this temperature for 2.5 hours. Upon completion of the reaction, it was quenched, cooled to room temperature and filtered to collect the yellow solid product. The resulting solid was dissolved in 500 ml of water with continuous stirring and gradual addition of water until the yellow solid was completely dissolved. The pH of the solution was adjusted to 6~7 with dilute hydrochloric acid (prepared from concentrated hydrochloric acid and water at a volume ratio of 1:3), at which time a white solid precipitated. The white solid was collected by filtration and washed with a small amount of acetone. After drying, Intermediate 2 was obtained as a white powdery solid with a yield of 168.4 g and 92%.
References
[1] Patent: CN103992278, 2016, B. Location in patent: Paragraph 0092; 0093
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 671,674
Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate manufacturers
- Product
- Ethyl 4-amino-2-hydroxy-5-pyrimidinecarboxylate 20187-46-6
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-12
- Product
- Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate 20187-46-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-10
- Product
- Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate 20187-46-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20