Lucatumumab
- Product Name
- Lucatumumab
- CAS No.
- 903512-50-5
- Chemical Name
- Lucatumumab
- Synonyms
- Lucatumumab;Lucatumumab (anti-CD40);Research Grade Lucatumumab;Research Grade Lucatumumab(DHD68905)
- CBNumber
- CB78080760
- Formula Weight
- 0
- MOL File
- Mol file
Lucatumumab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
Lucatumumab Chemical Properties,Usage,Production
Uses
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research[1][2].
IC 50
CD40
References
[1] Luqman M, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. 2008 Aug 1;112(3):711-20. DOI:10.1182/blood-2007-04-084756
[2] Drgona L, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4). Clin Microbiol Infect. 2018 Jun;24 Suppl 2:S83-S94. DOI:10.1016/j.cmi.2018.03.022
Lucatumumab Preparation Products And Raw materials
Raw materials
Preparation Products
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