1,3-Diaminopropane Property

Melting point:

-12 °C

Boiling point:

140 °C(lit.)

Density 

0.888 g/mL at 25 °C(lit.)

vapor pressure 

<8 mm Hg ( 20 °C)

refractive index 

n20/D 1.458(lit.)

Flash point:

120 °F

storage temp. 

Store below +30°C.

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

10.94(at 10℃)

form 

Liquid

color 

Clear

PH

>12 (100g/l, H2O, 20℃)

explosive limit

2.8-15.2%(V)

Water Solubility 

SOLUBLE

Sensitive 

Air Sensitive

BRN 

605277

Dielectric constant

9.6（Ambient）

Stability:

Stable. Hygroscopic. Flammable - readily forms explosive mixtures with air. Incompatible with acid anhydrides, acid chlorides, acids, strong oxidizing agents.

LogP

-1.05 at 25℃

CAS DataBase Reference

109-76-2(CAS DataBase Reference)

NIST Chemistry Reference

1,3-Propanediamine(109-76-2)

EPA Substance Registry System

1,3-Diaminopropane (109-76-2)

Safety

Hazard Codes 

T,C

Risk Statements 

10-22-24-35

Safety Statements 

26-36/37/39-45-25-16

RIDADR 

UN 2922 8/PG 2

WGK Germany 

2

RTECS 

TX6825000

F 

34

Autoignition Temperature

662 °F

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29212900

Toxicity

LD50 orally in Rabbit: 700 mg/kg LD50 dermal Rabbit 200 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H310Fatal in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1,3-Diaminopropane Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

1,3-Diaminopropane is commonly used in the preparation of cholinesterase inhibitors and thrombosis inhibitors. It is also used as a polymer cross linkage agent, polyurethane extender and spray coatings. It is involved in the preparation of agrochemicals and pharmaceutical intermediates. Further, it acts as a building block in the synthesis of heterocyclic compounds, which finds application in textile finishing. In addition to this, it is used as a ligand and form coordination complexes. 1,3-Diaminopropane is also utilized for the production of a chelating agent used in the photo industry and for anticorrosion agents.

Production Methods

1,3-Diaminopropane is produced in a twostage continuous process, under a pressure of 10 – 20 MPa. In a first reactor, acrylonitrile reacts with excess ammonia at 70 – 100 ℃ to give 2-aminopropionitrile and bis(cyanoethyl) amine. The mixture of aminonitriles is then hydrogenated in a downstream reactor over a fixed-bed catalyst (cobalt or nickel) at 60 – 120 ℃ to give 1,3-diaminopropane and bis (aminopropyl)amine. The yield of 1,3- diaminopropane can be increased by adding a polar solvent and water or by using a large excess of ammonia.

Definition

ChEBI: An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.

General Description

Water-white mobile liquid with an odor of amine.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

1,3-Diaminopropane is heat sensitive. 1,3-Diaminopropane may react with oxidizing agents.

Health Hazard

ACUTE/CHRONIC HAZARDS: 1,3-Diaminopropane is a strong irritant to eyes and skin: corrosive HAZARDOUS DECOMPOSITION PRODUCTS.

Fire Hazard

1,3-Diaminopropane is a flammable liquid.

Flammability and Explosibility

Flammable

Safety Profile

Poison by ingestion and skin contact. Experimental teratogenic effects. A severe skin and eye irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.