ChemicalBook > CAS DataBase List > 4-Amino-1-butanol

4-Amino-1-butanol

Product Name
4-Amino-1-butanol
CAS No.
13325-10-5
Chemical Name
4-Amino-1-butanol
Synonyms
4-aminobutan-1-ol;BUTANOLAMINE;4-AMINOBUTANOL;SKL271;N-ABU(4)-OL;H-ABUT(4)-OL;NH2-(CH2)4-OH;4-Aminobutanol-1;2-AcetyLhiophene;4-AMINO-1-BUTANOL
CBNumber
CB7853047
Molecular Formula
C4H11NO
Formula Weight
89.14
MOL File
13325-10-5.mol
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4-Amino-1-butanol Property

Melting point:
16-18 °C (lit.)
Boiling point:
206 °C (lit.)
Density 
0.967 g/mL at 25 °C (lit.)
refractive index 
n20/D ~1.462(lit.)
Flash point:
226 °F
storage temp. 
Store below +30°C.
solubility 
Acetonitrile (Slightly), Chloroform (Sparingly), Methanol (Slightly)
form 
Liquid
pka
15.10±0.10(Predicted)
color 
Clear colorless to slightly yellow
Water Solubility 
MISCIBLE
Sensitive 
Air Sensitive & Hygroscopic
BRN 
1731411
Stability:
Unstable in Aqueous Solution
CAS DataBase Reference
13325-10-5(CAS DataBase Reference)
NIST Chemistry Reference
NH2(CH2)4OH(13325-10-5)
EPA Substance Registry System
1-Butanol, 4-amino- (13325-10-5)
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Safety

Hazard Codes 
C
Risk Statements 
34-22
Safety Statements 
26-36/37/39-45-25
RIDADR 
UN 2735 8/PG 3
WGK Germany 
3
F 
34
HazardClass 
8
PackingGroup 
III
HS Code 
29221980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
178330
Product name
4-Amino-1-butanol
Purity
98%
Packaging
1g
Price
$39.9
Updated
2024/03/01
Sigma-Aldrich
Product number
178330
Product name
4-Amino-1-butanol
Purity
98%
Packaging
5g
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
A1013
Product name
4-Amino-1-butanol
Purity
>98.0%(GC)
Packaging
5g
Price
$69
Updated
2024/03/01
TCI Chemical
Product number
A1013
Product name
4-Amino-1-butanol
Purity
>98.0%(GC)
Packaging
25g
Price
$274
Updated
2024/03/01
Alfa Aesar
Product number
A12680
Product name
4-Amino-1-butanol, 98%
Packaging
1g
Price
$38.5
Updated
2023/06/20
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4-Amino-1-butanol Chemical Properties,Usage,Production

Description

4-Amino-1-butanol (4AB) is an important pharmaceutical intermediate compound and a precursor of biodegradable polymers for gene delivery. It can be used in organic synthesis and biological properties studies, among others. In addition, 4-Amino-1-butanol (4AB) has been shown to have a higher CO2 solubility than 2-amino-1-ethanol (MEA), which is potentially useful in solving problems related to flue gas purification[1-2].

Chemical Properties

Very light clear yellow liquid

Uses

4-Amino-1-butanol is a useful intermediate in a variety of organic synthesis. It is mainly used in personal-care products, preparation of water soluble cationic flocculants and ion exchange resins as well as in the preparation of beta-lactam antibiotics. It is used for the production of efficient anionic emulsifiers, nonionic polyethylene emulsions, water treatment, metal treatment and absorption of carbon dioxide gas. It is used as a pigment dispersion aid and curing agent in selected textile -resins.

Uses

4-Amino-1-butanol was used:

  • As a linker in the synthesis of highly branched poly(β-amino esters)(HPAEs) for gene delivery.
  • As a side chain to modulate antimicrobial and hemolytic activities of copolymers.
  • In the total synthesis of (+)-fawcettimine,(+)-fawcettidine, and (?)-lycojapodine A.

Preparation

4-Amino-1-butanol (4AB) can be prepared by microbiological methods. we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase (encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production. Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7?g/L of 4AB[1].

References

[1] CINDY PRICILIA SURYA PRABOWO. Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol[J]. Biotechnology and Bioengineering, 2020. DOI:10.1002/bit.27438.
[2] ZULKIFLI IDRIS . Equilibrium solubility of carbon dioxide in aqueous solutions of 3-amino-1-propanol, 4-amino-1-butanol and 5-amino-1-pentanol at low partial pressures[J]. Fluid Phase Equilibria, 2015. DOI:10.1016/j.fluid.2014.11.028.

4-Amino-1-butanol Preparation Products And Raw materials

Raw materials

Acetonitrile N,N-Dimethylformamide Potassium hydroxide Acetyl chloride Zinc chloride 4-Chloro-1-butanol Hydrazine hydrate Tetrahydrofuran Diethyl ether Cobalt chloride Potassium phthalimide

Preparation Products

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4-Amino-1-butanol Suppliers

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View Lastest Price from 4-Amino-1-butanol manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
4-Amino-1-butanol 13325-10-5
Price
US $980.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-10mt
Release date
2021-06-02
Shanghai UCHEM Inc.
Product
4-Amino-1-butanol 13325-10-5
Price
US $18.00-332.00/g
Min. Order
25g
Purity
0.98
Supply Ability
500kg
Release date
2024-10-28
Suzhou Ryan Pharmachem Technology Co.,Ltd.
Product
4-Amino-1-butanol 13325-10-5
Price
US $0.00-0.00/kg
Min. Order
10kg
Purity
98%
Supply Ability
ton grade
Release date
2023-05-10

13325-10-5, 4-Amino-1-butanolRelated Search:

4,4'-Diaminodiphenylsulfone 6-Aminocaproic acid Acetaminophen tert-Butanol ALTRENOGEST Glucosamine Tris(hydroxymethyl)aminomethane 2-Butanol EC 2.6.1.2 Sulfamic acid 4-Dimethylaminopyridine 4-Amino-benzenesulfonic acid monosodium salt Glycine 1-Butanol (S)-(+)-2-Amino-1-butanol 1-AMINO-2-BUTANOL 4,4'-Azobis(4-cyanovaleric acid) Daminozide

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