ChemicalBook > CAS DataBase List > 5-Hydroxy-1-tetralone

5-Hydroxy-1-tetralone

Product Name: 5-Hydroxy-1-tetralone
CAS No.: 28315-93-7
Chemical Name: 5-Hydroxy-1-tetralone
Synonyms: 5-hydroxy-3,4-dihydronaphthalen-1(2H)-one;1-TETRALON-5-OL;5-Hydroxy-1-tetraL;5-HYDROY-1-TETRAIONE;5-HYDROXY-1-TETRALONE;5-Hydroxy-α-tetralone;5-Hydroxy-1-tetrazole;Levobunolol Impurity 5;5-Hydroxytetralin-1-one;5-hydroxy-1-oxotetraline
CBNumber: CB8111979
Molecular Formula: C10H10O2
Formula Weight: 162.19
MOL File: 28315-93-7.mol

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5-Hydroxy-1-tetralone Property

Melting point:: 206-209 °C (lit.)
Boiling point:: 228.88°C (rough estimate)
Density: 1.0281 (rough estimate)
refractive index: 1.5380 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in alcohol, ether, benzene and acetic acid.
form: Solid
pka: 9.37±0.20(Predicted)
color: White to Off-White
BRN: 2437410
InChI: InChI=1S/C10H10O2/c11-9-5-1-3-7-8(9)4-2-6-10(7)12/h1,3,5,11H,2,4,6H2
InChIKey: YPPZCRZRQHFRBH-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C(O)=CC=C2)CCC1
CAS DataBase Reference: 28315-93-7(CAS DataBase Reference)
NIST Chemistry Reference: 5-Hydroxy-1-tetralone(28315-93-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219975
Product name: 5-Hydroxy-1-tetralone
Purity: 99%
Packaging: 5g
Price: $47.88
Updated: 2025/07/31

TCI Chemical

Product number: H0614
Product name: 5-Hydroxy-1-tetralone
Purity: >99.0%(GC)
Packaging: 1g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: H0614
Product name: 5-Hydroxy-1-tetralone
Purity: >99.0%(GC)
Packaging: 5g
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: H0614
Product name: 5-Hydroxy-1-tetralone
Purity: >99.0%(GC)
Packaging: 25g
Price: $326
Updated: 2025/07/31

Usbiological

Product number: 014551
Product name: 5-Hydroxy-1-tetralone
Packaging: 10g
Price: $425
Updated: 2021/12/16

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5-Hydroxy-1-tetralone Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige or pinkish crystalline

Uses

5-Hydroxy-1-tetralone, is used as a metabolite of Levobunolol (L335000) and d-Bunolol (L335010). It is also used as a reagent for the determination of hexoses and oligosaccharides by a fluorescence technique. A reagent that is used for fluorescence determination of enzyme activity. Some of the other applications include as internal standard during HPLC determination of 4-hydroxymephenytoin (4-OH-M) in human urine, as fluorescent labeling reagent during micro detection of glycosphingolipid on TLC plates, in synthesis of 1,2,3,4-tetrahydro-5H-1-benzazepine-quinone derivatives, in synthesis of new chiral oxathiane.

Synthesis

83-56-7

28315-93-7

The general procedure for the synthesis of 5-hydroxy-1-tetralone from 1,5-dihydroxynaphthalene is as follows: Example 1-1 Method A Preparation of [5-(biphenyl-4-sulfonylamino)-5,6,7,8-tetrahydronaphthalen-1-yloxy]-acetic acid; Synthesis of 5-hydroxy-3,4-dihydro-2H-naphthalen-1-one To a mixed solution of isopropanol (150 mL) and aqueous sodium hydroxide (40 mL) containing 1,5-dihydroxynaphthalene (25.0 g, 156 mmol) was added 10% palladium carbon catalyst (3.9 g) at room temperature. The reaction mixture was transferred to a Parr autoclave (Parr Instrument Company) and reacted at 80 °C for 20 h under 100 psi hydrogen pressure. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through a diatomaceous earth pad (diatomaceous earth filter from World Minerals Inc.) and the filter cake was washed with isopropanol (200 mL). The combined filtrates were treated with activated carbon at 50 °C for 1 h and subsequently filtered through a Celite pad (diatomaceous earth filter). Isopropanol was removed by distillation under reduced pressure and the pH was adjusted to about 2 by slowly adding concentrated hydrochloric acid to the remaining solution, at which point a solid precipitated. The solid product was collected, washed with water (100 mL x 2), and then dried under high vacuum at 50 °C to afford 5-hydroxy-3,4-dihydro-2H-naphthalen-1-one (15.0 g, 60% yield) as a dark brown solid, which can be used in subsequent steps without further purification. Mass spectrometry analysis: calculated value (C10H10O2) 162, measured value (M+H)+ 163.

References

[1] Russian Journal of Organic Chemistry, 2000, vol. 36, # 10, p. 1474 - 1477
[2] Patent: US2010/41714, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: US2010/41760, 2010, A1. Location in patent: Page/Page column 7; 23-24
[4] Journal of Organic Chemistry, 2017, vol. 82, # 18, p. 9844 - 9850

5-Hydroxy-1-tetralone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Hydroxy-1-tetralone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Hydroxy-1-tetralone 28315-93-7
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Yanxi Chemical Co., Ltd.

Product: 5-Hydroxy-1-tetralone 28315-93-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-30

Henan Bao Enluo International TradeCo.，LTD

Product: 5-Hydroxy-1-tetralone 28315-93-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-30

28315-93-7, 5-Hydroxy-1-tetraloneRelated Search:

Hydroxy silicone oil 4'-Hydroxyacetophenone Chrysin 1-Tetralone 10-Hydroxycamptothecin Hydroxyapatite CHLOROPHOSPHONAZO III beta-Tetralone Glycolic acid 1,2,3,4-Tetrahydronaphthalene LEVOBUNOLOL 5-Methoxy-3,4-dihydro-2H-naphthalen-1-one Bunolol 2,3-DIHYDRO-9,10-DIHYDROXY-1,4-ANTHRACENEDIONE Levobunolol hydrochloride 6-HYDROXY-1-TETRALONE,6-HYDROXY-1-TETRALONE 98.5% 7-HYDROXY-1-TETRALONE napyradiomycin C1

1(2H)-Naphthalenone, 3,4-dihydro-5-hydroxy-

3,4-dihydro-5-hydroxy-1(2h)-naphthalenon

5-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE

5-HYDROXY-1-TETRALONE

1-TETRALON-5-OL

5-hydroxy-1-oxotetraline

1,2,3,4-tetrahydro-5-hydroxynaphthalen-1-one

5-HYDROY-1-TETRAIONE

5-Hydroxy-1-tetralone,99%

3,4-Dihydro-5-hydroxy-1(2H)-naphthalenone

5-Hydroxy-1,2,3,4-tetrahydronaphthalene-1-one

5-Hydroxy-3,4-dihydronaphthalene-1(2H)-one

5-Hydroxytetralin-1-one

3,4-Dihydro-5-Hydroxyl-1(2H)-Naphthalen one 5-Hydroxy-1-Tetralone

1,2,3,4-Tetrahydro-1-oxo-5-hydroxynaphthalene

1,2,3,4-Tetrahydro-5-hydroxynaphthyl-1-one

5-Hydroxy-1,2,3,4-tetrahydronapht

5-Hydroxy-α-tetralone

5-hydroxy-3,4-dihydronaphthalen-1(2H)-one

5-Hydroxy-1-tetrazole

5-Hydroxy-3,4-dihydro-2H-naphthalen-1-one

5-Hydroxy-1-tetralone 99%

5-Hydroxy-1-tetralone&gt

5-Hydroxy-1-tetraL

5-hydroxy-1-tetrahydronaphthalene ketone

Benzoicacid,5-acetyl-7-hydroxy-,methylester

5-Hydroxy-1-tetralone, ≥ 99.0%

5-Hydroxy-1-tetralone, 10 mM in DMSO

5-hydroxy-1-tetrahydronaphthone

Levobunolol Impurity 5

28315-93-7

C10H10O2

KETONE

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C10

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