1,3-Thiazol-2-ylmethanol
- Product Name
- 1,3-Thiazol-2-ylmethanol
- CAS No.
- 14542-12-2
- Chemical Name
- 1,3-Thiazol-2-ylmethanol
- Synonyms
- )-1,3-thiazoL;2-THIAZOLEMETHANOL;RARECHEM AL BD 0750;Thiazole-2-Methanol;THIAZOL-2-YL-METHANOL;2-HYDROXYMETHYLTHIAZOLE;1,3-THIAZOL-2-YLMETHANOL;2-(Hydroxylmethyl)thiazole;2-(Hydroxymethyl)thiazole >2-(Hydroxymethyl)-1,3-thiazole
- CBNumber
- CB8124711
- Molecular Formula
- C4H5NOS
- Formula Weight
- 115.15
- MOL File
- 14542-12-2.mol
1,3-Thiazol-2-ylmethanol Property
- Melting point:
- 62-64.5
- Boiling point:
- 76°C/0.2mmHg(lit.)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 12.87±0.10(Predicted)
- color
- White to Orange to Green
- CAS DataBase Reference
- 14542-12-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-26-36/37/39
- Hazard Note
- Harmful
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H1476
- Product name
- 2-(Hydroxymethyl)thiazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $97
- Updated
- 2025/07/31
- Product number
- T344695
- Product name
- 1,3-Thiazol-2-ylmethanol
- Packaging
- 5g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 411173
- Product name
- 1,3-Thiazol-2-ylmethanol
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 291374
- Product name
- 1,3-Thiazol-2-ylmethanol
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- CHM0018971
- Product name
- 2-(HYDROXYMETHYL)-1,3-THIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
1,3-Thiazol-2-ylmethanol Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
1,3-Thiazol-2-ylmethanol is a reagent used in the synthesis of quinazoline analogs which is an anti-proliferative activities and EGFR inhibitory potency.
Synthesis
10200-59-6
14542-12-2
General procedure for the synthesis of 2-hydroxymethylthiazole from 2-formylthiazole: Thiazole-2-carbaldehyde (301 mg, 2.66 mmol) was dissolved in methanol (15 mL) at 0 °C. Subsequently, sodium borohydride (151 mg, 3.99 mmol) was slowly added to the reaction system and the reaction was continuously stirred for 2 h at this temperature. Upon completion of the reaction, the reaction mixture was poured into water (10 mL) to terminate the reaction. The solvent was removed by rotary evaporator and the resulting residue was extracted with ethyl acetate (15 mL x 3). The organic phases were combined, washed with saturated saline (15 mL) and dried over anhydrous sodium sulfate. After filtration, the organic solvent was removed by concentration under reduced pressure, and the crude product obtained was purified by column chromatography (eluent: petroleum ether/ethyl acetate, 5:1, v/v/v/v), and finally 285 mg of a light yellow oily product was obtained with a yield of 93%.
References
[1] Chinese Journal of Chemistry, 2014, vol. 32, # 6, p. 538 - 544
[2] Patent: CN106749268, 2017, A. Location in patent: Paragraph 0798; 0799
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 33, p. 4972 - 4983
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, vol. 62, # 12, p. 1525 - 1529
[5] Tetrahedron, 1988, vol. 44, # 7, p. 2021 - 2032
1,3-Thiazol-2-ylmethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-Thiazol-2-ylmethanol manufacturers
- Product
- 2-(HydroxyMethyl)thiazole 14542-12-2
- Price
- US $2340.00-2000.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 5mt
- Release date
- 2025-06-08
- Product
- 1,3-Thiazol-2-ylmethanol 14542-12-2
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04