1,3-Thiazol-2-ylmethanol

Product Name: 1,3-Thiazol-2-ylmethanol
CAS No.: 14542-12-2
Chemical Name: 1,3-Thiazol-2-ylmethanol
Synonyms: )-1,3-thiazoL;2-THIAZOLEMETHANOL;RARECHEM AL BD 0750;Thiazole-2-Methanol;THIAZOL-2-YL-METHANOL;2-HYDROXYMETHYLTHIAZOLE;1,3-THIAZOL-2-YLMETHANOL;2-(Hydroxylmethyl)thiazole;2-(Hydroxymethyl)thiazole >2-(Hydroxymethyl)-1,3-thiazole
CBNumber: CB8124711
Molecular Formula: C4H5NOS
Formula Weight: 115.15
MOL File: 14542-12-2.mol

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1,3-Thiazol-2-ylmethanol Property

Melting point:: 62-64.5
Boiling point:: 76°C/0.2mmHg(lit.)
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 12.87±0.10(Predicted)
color: White to Orange to Green
CAS DataBase Reference: 14542-12-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
Hazard Note: Harmful
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1476
Product name: 2-(Hydroxymethyl)thiazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $97
Updated: 2025/07/31

TRC

Product number: T344695
Product name: 1,3-Thiazol-2-ylmethanol
Packaging: 5g
Price: $175
Updated: 2021/12/16

Usbiological

Product number: 411173
Product name: 1,3-Thiazol-2-ylmethanol
Packaging: 1g
Price: $305
Updated: 2021/12/16

Usbiological

Product number: 291374
Product name: 1,3-Thiazol-2-ylmethanol
Packaging: 500mg
Price: $333
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: H11246
Product name: 2-(Hydroxymethyl)thiazole
Purity: 95%
Packaging: 1g
Price: $25
Updated: 2021/12/16

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1,3-Thiazol-2-ylmethanol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

1,3-Thiazol-2-ylmethanol is a reagent used in the synthesis of quinazoline analogs which is an anti-proliferative activities and EGFR inhibitory potency.

Synthesis

10200-59-6

14542-12-2

General procedure for the synthesis of 2-hydroxymethylthiazole from 2-formylthiazole: Thiazole-2-carbaldehyde (301 mg, 2.66 mmol) was dissolved in methanol (15 mL) at 0 °C. Subsequently, sodium borohydride (151 mg, 3.99 mmol) was slowly added to the reaction system and the reaction was continuously stirred for 2 h at this temperature. Upon completion of the reaction, the reaction mixture was poured into water (10 mL) to terminate the reaction. The solvent was removed by rotary evaporator and the resulting residue was extracted with ethyl acetate (15 mL x 3). The organic phases were combined, washed with saturated saline (15 mL) and dried over anhydrous sodium sulfate. After filtration, the organic solvent was removed by concentration under reduced pressure, and the crude product obtained was purified by column chromatography (eluent: petroleum ether/ethyl acetate, 5:1, v/v/v/v), and finally 285 mg of a light yellow oily product was obtained with a yield of 93%.

References

[1] Chinese Journal of Chemistry, 2014, vol. 32, # 6, p. 538 - 544
[2] Patent: CN106749268, 2017, A. Location in patent: Paragraph 0798; 0799
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 33, p. 4972 - 4983
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, vol. 62, # 12, p. 1525 - 1529
[5] Tetrahedron, 1988, vol. 44, # 7, p. 2021 - 2032

1,3-Thiazol-2-ylmethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3-Thiazol-2-ylmethanol manufacturers

Sach biotech Co.,Ltd

Product: 2-(HydroxyMethyl)thiazole 14542-12-2
Price: US $2340.00-2000.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5mt
Release date: 2025-06-08

Career Henan Chemical Co

Product: 1,3-Thiazol-2-ylmethanol 14542-12-2
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-04

14542-12-2, 1,3-Thiazol-2-ylmethanolRelated Search:

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RARECHEM AL BD 0750

1,3-THIAZOL-2-YLMETHANOL

2-HYDROXYMETHYLTHIAZOLE

2-THIAZOLEMETHANOL

2-(Hydroxymethyl)-1,3-thiazole

2-(Hydroxymethyl)-1,3-thiazole 97%

THIAZOL-2-YL-METHANOL

2-(Hydroxylmethyl)thiazole

Thiazole-2-Methanol

1,3-Thiazol-2-Ylmethanol(WX640084)

2-(Hydroxymethyl)thiazole &gt

)-1,3-thiazoL

14542-12-2

Building Blocks

Thiazole

Thiazoles, Isothiazoles & Benzothiazoles

Thiazole series

Hydroxymethyl's

Thiazoles, Isothiazoles &Benzothiazoles

API intermediates