Xylazine

ChemicalBook > CAS DataBase List > Xylazine

Product Name: Xylazine
CAS No.: 7361-61-7
Chemical Name: Xylazine
Synonyms: Xylazine (free base);2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine;wh7286;Xylazin;bay1470;XYLAZINE;Xilazina;Mobay Rompun;Xylazine, >=99%;Xylazine powder
CBNumber: CB8130978
Molecular Formula: C12H16N2S
Formula Weight: 220.33
MOL File: 7361-61-7.mol

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Xylazine Property

Melting point:: 140 C
Boiling point:: 334.2±52.0 °C(Predicted)
Density: 1.0905 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: -20°C
solubility: Soluble in methanol at 50mg/ml. Also soluble in dilute acid solutions.
pka: 7.67±0.20(Predicted)
form: Powder
InChI: InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
InChIKey: BPICBUSOMSTKRF-UHFFFAOYSA-N
SMILES: S1CCCN=C1NC1=C(C)C=CC=C1C
CAS DataBase Reference: 7361-61-7(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36/37/38
Safety Statements: 45-37/39-26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: XJ0776300
HazardClass: 6.1
HS Code: 2934990002
Toxicity: LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: X1126
Product name: Xylazine
Purity: ≥99%
Packaging: 1g
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3263
Product name: Xylazine
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1720407
Product name: Xylazine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $432
Updated: 2024/03/01

Alfa Aesar

Product number: J61430
Product name: Xylazine
Packaging: 25g
Price: $490
Updated: 2021/12/16

Alfa Aesar

Product number: J61430
Product name: Xylazine
Packaging: 5g
Price: $116
Updated: 2021/12/16

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Xylazine Chemical Properties,Usage,Production

Description

Xylazine is an agonist of α₂-adrenergic receptors (K_i = 194 nM). It is an analog of clonidine, an α₂-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard .

Originator

Xylazine,Bayer

Uses

Antinociceptive;Alpha-2 adrenergic agonist

Uses

Xylazine is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors as an a 2-adrenergic agonist.

Definition

ChEBI: Xylazine is a methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties. It has a role as an emetic, an alpha-adrenergic agonist, a sedative, a muscle relaxant and an analgesic. It is a methylbenzene, a 1,3-thiazine and a secondary amino compound. It is a conjugate base of a xylazine(1+).

Manufacturing Process

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline with thiophosgene, were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated hydrochloric acid and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated sodium hydroxide solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical).

Therapeutic Function

Analgesic, Anesthetic

Origin

Xylazine was discovered as an antihypertensive agent in 1962 by Farbenfabriken Bayer in Leverkusen, Germany. Accounts of the actions and uses of xylazine in animals were reported as early as the late 1960s and early 1970s. Results from early human clinical studies confirmed that xylazine has several central nervous system depressant effects.

General Description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

Biochem/physiol Actions

Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.

Mechanism of action

Xylazine is marketed as its hydrochloride salt as Rompun (100 mg/mL) and Anased (20 mg/mL) injectable solutions for intravenous administration to horses and dogs, respectively. The actions of xylazine may be reversed by the administration of yohimbine, an indolalkylamine alkaloid, that blocks those α2- adrenoreceptors that are stimulated by xylazine.

Side effects

High doses of Xylazine can cause dizziness, vomiting, high blood sugar, blurry vision and even overdose deaths. If you inject xylazine into your body, you also may develop skin ulcers and severe wounds that can spread and worsen quickly. Xylazine can lead to depression of the central nervous system along with other adverse effects. As for animals, they may show profound salivation following an injection with xylazine. Other adverse effects for dogs and cats include: muscle tremors, bradycardia with AV-block, hypotension, reduced respiratory rate, movement in response to strong auditory stimuli, and increased urination in cats.

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Xylazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Xylazine manufacturers

Anhui Yiao New Material Technology Co., Ltd

Product: Xylazine 7361-61-7
Price: US $90.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20tons
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine 7361-61-7
Price: US $50.00-40.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-11-02

Shanghai Longyu Biotechnology Co., Ltd.

Product: xylazine 7361-61-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99
Supply Ability: 20tons
Release date: 2022-01-19

7361-61-7, XylazineRelated Search:

Chlorodimethylphenylsilane Hydrochlorothiazide Chlorothiazide Buprofezin Diethanolamine Toltrazuril Phenothiazine DIAZOXIDE Bis(2-ethylhexyl)amine Dihydromyrcenol Xylazine Hydrochloride Thiamethoxam Xylometazoline hydrochloride Ethylmagnesium bromide Raspberry Ketone 2,6-DIMETHYLPHENYL ISOTHIOCYANATE BENZTHIAZIDE XYLAZINE

2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine

2-(2,6-dimethylphenylamino)-4h-5,6-dihydro-1,3-thiazine

5,6-dihydro-2-(2,6-xylidino)-4h-1,3-thiazine

5,6-dihydro-2-(2,6-xylidino)-4h-3-thiazine

2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine

Xylazine Base & HCL

Xylazine,2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride

Xylazine (200 mg)

Xylazine(RoMpun)

(5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-diMethyl-phenyl)-aMine, N-(2,6-DiMethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-aMine

Xylazine N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine

Xylazine, >=99%

Xylazin

bay1470

n-(2,6-dimethylphenyl)-5,6-dihydro-4h-3-thiazine-2-amine

n-(5,6-dihydro-4h-1,3-thiazinyl)-6-xylidine

wh7286

N-(2,6-DIMETHYLPHENYL)-5,6-DIHYDRO-4H-1,3-THIAZIN-2-AMINE

XYLAZINE

2-[2,6-DIMETHYLPHENYLAMINO]-4H-5,6-DIHYDROTHIAZINE

(5,6-DIHYDRO-4H-[1,3]THIAZIN-2-YL)-(2,6-DIMETHYLPHENYL)-AMINE

AKOS BBS-00000613

XYLAZINE HYDROCHLORIDE A2 ADRENOCEPTOR A GONI

XYLAZINE, IMPURITY EN-(2,6-DIMETHYLPHENYL)-S-METHYLDITHIOUREA EP STANDARD

XYLAZINE, USP STANDARD

XYLAZINE, IMPURITY C2,6-DIMETHYLPHENYL ISOTHIOCYANATE EP STANDARD

4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-

XYLAZINE HCL/BASE

1,3-THIAZINE,5,6-DIHYDRO-2-(2,6-XYLIDINO)-

Xylazine (free base)

xylazine free base

(5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-p

Mobay Rompun

2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-1,3-thiazine

Trimethothiazine

2(-2,6-Dimethylphenylamino)-5

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7361-61-7