ChemicalBook > CAS DataBase List > Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- Product Name
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- CAS No.
- 131707-24-9
- Chemical Name
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- Synonyms
- Si-5;Ethyl 6-broMo-5-hydroxy-1-Methyl-2-((phenylthio)Methyl)-1H-Indole-3-carboxylate;Si 5;Ethyl 6-bromo-5;Abidol Impurity;Abidol Impurity 18;Si 5 (pharmaceutical);Abbidore intermediate 5;Impurities in Arbidol908;Ethyl 6-bromo-5-hydroxy-1-methyl-2-((phenylthio)methyl)
- CBNumber
- CB81417913
- Molecular Formula
- C19H18BrNO3S
- Formula Weight
- 420.32
- MOL File
- 131707-24-9.mol
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Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate Property
- Melting point:
- >192°C (dec.)
- Boiling point:
- 570.6±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Sparingly, Heated)
- pka
- 7.60±0.40(Predicted)
- form
- Solid
- color
- White to Light Brown
- InChI
- InChI=1S/C19H18BrNO3S/c1-3-24-19(23)18-13-9-17(22)14(20)10-15(13)21(2)16(18)11-25-12-7-5-4-6-8-12/h4-10,22H,3,11H2,1-2H3
- InChIKey
- DAFNNZWQTJQQAP-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(C=C(O)C(Br)=C2)C(C(OCC)=O)=C1CSC1=CC=CC=C1
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Safety
- HazardClass
- IRRITANT
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
TRC
- Product number
- B683905
- Product name
- 6-Bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylicAcidEthylEster
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
TRC
- Product number
- B683905
- Product name
- 6-Bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylicAcidEthylEster
- Packaging
- 5g
- Price
- $105
- Updated
- 2021/12/16
AK Scientific
- Product number
- J52105
- Product name
- Ethyl6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
AK Scientific
- Product number
- B811
- Product name
- Ethyl6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- Packaging
- 5g
- Price
- $21
- Updated
- 2021/12/16
AK Scientific
- Product number
- B811
- Product name
- Ethyl6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- Packaging
- 25g
- Price
- $67
- Updated
- 2021/12/16
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Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate Chemical Properties,Usage,Production
Uses
6-Bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic Acid Ethyl Ester is used to prepare anti-hepatitis B virus activities of Et bromohydroxyindolecarboxylates.
Synthesis
110543-98-1
108-98-5
131707-24-9
To 900 mL of methanol was added 30 g of sodium hydroxide (0.75 mol) and stirred until completely dissolved to form a clarified solution. Subsequently, 39.7 g of benzenethiol (0.36 mol) was added to this solution and the reaction was continued with stirring for 2 hours. Next, 130 g of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate (0.30 mol) was added and the reaction was continued with stirring for 3 hours. Upon completion of the reaction, the reaction mixture was neutralized with acetic acid and a large amount of solid was observed to precipitate. The mixture was allowed to stand, the solid was collected by filtration and the filter cake was washed with cold water. Finally, the crude product was recrystallized from ethyl acetate and dried to give 114.5 g of ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylthiomethyl)indole-3-carboxylate in 90.8% yield.
References
[1] Pharmaceutical Chemistry Journal, 1993, vol. 27, # 1, p. 75 - 76
[2] Khimiko-Farmatsevticheskii Zhurnal, 1993, vol. 27, # 1, p. 70 - 71
[3] Patent: CN106083691, 2016, A. Location in patent: Paragraph 0025; 0059
[4] Patent: US5198552, 1993, A
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate 131707-24-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.5%
- Supply Ability
- 100kg
- Release date
- 2025-09-01
Nanjing Fred Technology Co., Ltd
- Product
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate 131707-24-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%HPLC
- Supply Ability
- 20 tons
- Release date
- 2023-12-04
Jinan Shengqi pharmaceutical Co,Ltd
- Product
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate 131707-24-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 50MT
- Release date
- 2019-03-06
131707-24-9, Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylateRelated Search:
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