2-Methyl-3-amino-4-acetylanisole
- Product Name
- 2-Methyl-3-amino-4-acetylanisole
- CAS No.
- 912347-94-5
- Chemical Name
- 2-Methyl-3-amino-4-acetylanisole
- Synonyms
- 2-methyl-3-amino-4-acetylanisole;6-ACETYL-3-METHOXY-2-METHYL ANILINE;1-(2-aMino-4-Methoxy-3-Methylphenyl)-;2-AMino-4-Methoxy-3-Methylacetophenone;2-Amino-4-methoxy-3-methylbenzoic acid;(2-Amino-3-methyl-4-methoxyphenyl)acetone;2'-Amino-3'-methyl-4'-methoxyacetophenone;2-Methyl-3-amino-4-acetylanisole USP/EP/BP;1-(2-Amino-4-methoxy-3-methylphenyl)ethanone;1-(2-aMino-4-Methoxy-3-Methylphenyl)ethan-1-one
- CBNumber
- CB81465767
- Molecular Formula
- C10H13NO2
- Formula Weight
- 179.22
- MOL File
- 912347-94-5.mol
2-Methyl-3-amino-4-acetylanisole Property
- Melting point:
- 107 °C
- Boiling point:
- 336.0±37.0 °C(Predicted)
- Density
- 1.096±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 1.74±0.10(Predicted)
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C10H13NO2/c1-6-9(13-3)5-4-8(7(2)12)10(6)11/h4-5H,11H2,1-3H3
- InChIKey
- VXBGCEDOGYNWHE-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=C(OC)C(C)=C1N)C
Safety
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A3027
- Product name
- 2'-Amino-3'-methyl-4'-methoxyacetophenone
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- A3027
- Product name
- 2'-Amino-3'-methyl-4'-methoxyacetophenone
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $312
- Updated
- 2025/07/31
- Product number
- A613115
- Product name
- 1-(2-Amino-4-methoxy-3-methylphenyl)ethanone
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- A613115
- Product name
- 1-(2-Amino-4-methoxy-3-methylphenyl)ethanone
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- OR301383
- Product name
- 1-(2-Amino-4-methoxy-3-methylphenyl)ethanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
2-Methyl-3-amino-4-acetylanisole Chemical Properties,Usage,Production
Synthesis
75-05-8
19500-02-8
912347-94-5
To a solution of 2-methyl-3-methoxyaniline (5.0 g, 36.5 mmol) in p-xylene (80 mL) was cooled to 0 °C, and a dichloromethane solution (36.5 mL) of 1 M BCl3 was slowly added. The reaction mixture was stirred at 0 °C for 30 min under nitrogen protection. Subsequently, acetonitrile (2.6 mL, 54.7 mmol) was added and stirring was continued at 0 °C for 30 min. In another reaction flask, AlCl3 (4.87 g, 36.5 mmol) was suspended in anhydrous dichloromethane (50 mL), cooled to 0 °C, and the aforementioned p-xylene solution was added dropwise through the addition funnel under nitrogen protection. After addition, the dichloromethane was removed under vacuum after stirring at 0°C for 45 minutes. The remaining p-xylene solution was heated to 70°C and maintained for 18 hours, followed by cooling to room temperature. Water (80 mL) was added and again heated to 70°C maintained for 1 hour and cooled to room temperature. The reaction mixture was diluted with ethyl acetate and the aqueous layer was separated. The organic layer was washed sequentially with equal volumes of water and saturated saline, dried over anhydrous MgSO4 and concentrated under reduced pressure. 1H), 7.03 (br.s., 2H), 7.65 (d, J = 9.04 Hz, 1H). LC-MS (ESI): m/z 180.10 (M + H)+.
References
[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3021 - 3026
[3] Patent: WO2008/96002, 2008, A1. Location in patent: Page/Page column 82-83
[4] Patent: WO2008/92954, 2008, A2. Location in patent: Page/Page column 28-29
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 17, p. 4853 - 4858
2-Methyl-3-amino-4-acetylanisole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methyl-3-amino-4-acetylanisole Suppliers
- Tel
- 18957127338 18305707819;
- sales@zetchem.com
- Country
- China
- ProdList
- 500
- Advantage
- 58
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-34975603-808 18721111801
- Fax
- +86-21-34975602-805
- sales@bocpharma.com
- Country
- China
- ProdList
- 1009
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 86-25-57062118
- Fax
- 86-25-57065896
- sales@jspsn.com
- Country
- China
- ProdList
- 496
- Advantage
- 57
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
View Lastest Price from 2-Methyl-3-amino-4-acetylanisole manufacturers
- Product
- 2-Methyl-3-amino-4-acetylanisole 912347-94-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KG
- Release date
- 2019-09-04