Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

ChemicalBook > CAS DataBase List > Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

Product Name: Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
CAS No.: 179688-26-7
Chemical Name: Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
Synonyms: ERLOTINIBIM-B;ERLOTINIBINT-C;Erlotinib Impurity 6;Erlotinib interMidiate III;Erlotinib Hydrochloride iMpurity 25;Ethyl 4,5-Bis(2-Methoxyethoxy)-2-Nitrobe;4,5-bis(2-methoxyethoxy)-2-nitrobenzoate;Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate;Methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate;4,5-Bis(2-methoxyethoxy)-2-nitrobenzoic acid ethyl ester
CBNumber: CB81504004
Molecular Formula: C15H21NO8
Formula Weight: 343.33
MOL File: 179688-26-7.mol

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Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Property

Boiling point:: 467.8±45.0 °C(Predicted)
Density: 1.215
storage temp.: Refrigerator
solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
form: Oil
color: Yellow
CAS DataBase Reference: 179688-26-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: E900080
Product name: Ethyl4,5-Bis(2-methoxyethoxy)-2-nitrobenzoate
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 094640
Product name: Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
Purity: 95+%
Packaging: 1g
Price: $103
Updated: 2021/12/16

Matrix Scientific

Product number: 094640
Product name: Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
Purity: 95+%
Packaging: 5g
Price: $357
Updated: 2021/12/16

AK Scientific

Product number: B654
Product name: Ethyl4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
Packaging: 250mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: J11301
Product name: ErlotinibImpurity6
Packaging: 25mg
Price: $60
Updated: 2021/12/16

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Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Chemical Properties,Usage,Production

Uses

Ethyl 4,5-Bis(2-methoxyethoxy)-2-nitrobenzoate is used in the syntheses of 4-(indol-3-yl)quinazolines as epidermal growth factor receptor tyrosine kinase inhibitors. It is also used to prepare Erlotinib hydrochloride (E625000), a useful drug in treatment of non-?small-?cell lung cancer.

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

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Erlotinib interMidiate III

Benzoic acid,4,5-bis(2-Methoxyethoxy)-2-nitro-, ethyl ester

Erlotinib Impurity 6

4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate ###179688-26-7

ERLOTINIBINT-C

ERLOTINIBIM-B

Ethyl 4,5-Bis(2-Methoxyethoxy)-2-Nitrobe

Erlotinib Hydrochloride iMpurity 25

179688-26-7

C15H21NO8

Erlotinib INTERMEDIATES